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Voluntary exercise prevents lead-induced elevation of oxidative stress and inflammation markers in male rat blood.

Mohammadi M, Ghaznavi R, Keyhanmanesh R, Sadeghipour HR, Naderi R, Mohammadi H - ScientificWorldJournal (2013)

Bottom Line: Glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA), and tumor necrosis factor (TNF-α) were measured in the samples.Our results showed that lead administration reduced blood SOD, GPx and CAT and increased TNF-α; in the controls, but in the exercise group, changes were not statistically significant.MDA in both groups increased after lead injections but it was significantly lower in exercise group compared to the sedentary animals.

View Article: PubMed Central - PubMed

Affiliation: Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz 51656-65811, Iran.

ABSTRACT
Regular mild exercise enhances antioxidant and anti-inflammatory systems of the body. The present study investigates voluntary exercise effects on lead toxicity as a known oxidative stressor. Male Sprague-Dawley rats were randomly divided into 2 groups. Sedentary control: the animals were housed 7 weeks in the regular cages. Exercise group: the animals were housed 7 weeks in the running wheel equipped cages, that is, the animal model of voluntary exercise. During the 7th week, all animals were administered lead acetate. Blood samples were collected at the end of the 6th week and 7th week (before and after lead administrations). Glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA), and tumor necrosis factor (TNF-α) were measured in the samples. Our results showed that lead administration reduced blood SOD, GPx and CAT and increased TNF-α; in the controls, but in the exercise group, changes were not statistically significant. MDA in both groups increased after lead injections but it was significantly lower in exercise group compared to the sedentary animals. We concluded that voluntary exercise may be considered as a preventive tool against lead-induced oxidative stress and inflammation.

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Plasma tumor necrosis factor-α in sedentary control and exercise groups before and after lead administrations. Seven days of lead injections (15 mg/Kg body weight, ip) to sedentary animals housed in the regular cages caused significant increase of plasma TNF-α (*P < 0.05 compared to the “before lead administration”); in Ex animals housed in the wheel equipped cages, plasma TNF-α changes after the same dose lead administrations were not significant. The data are presented as means ± S.E.M. TNF-α: tumor necrosis factor-α; Sed Co: sedentary control group; Ex: exercise group.
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fig5: Plasma tumor necrosis factor-α in sedentary control and exercise groups before and after lead administrations. Seven days of lead injections (15 mg/Kg body weight, ip) to sedentary animals housed in the regular cages caused significant increase of plasma TNF-α (*P < 0.05 compared to the “before lead administration”); in Ex animals housed in the wheel equipped cages, plasma TNF-α changes after the same dose lead administrations were not significant. The data are presented as means ± S.E.M. TNF-α: tumor necrosis factor-α; Sed Co: sedentary control group; Ex: exercise group.

Mentions: Mean plasma TNF-α level was significantly increased after 7 days of lead injections in sedentary control group but in exercise group TNF-α did not significantly change after lead administration (Figure 5).


Voluntary exercise prevents lead-induced elevation of oxidative stress and inflammation markers in male rat blood.

Mohammadi M, Ghaznavi R, Keyhanmanesh R, Sadeghipour HR, Naderi R, Mohammadi H - ScientificWorldJournal (2013)

Plasma tumor necrosis factor-α in sedentary control and exercise groups before and after lead administrations. Seven days of lead injections (15 mg/Kg body weight, ip) to sedentary animals housed in the regular cages caused significant increase of plasma TNF-α (*P < 0.05 compared to the “before lead administration”); in Ex animals housed in the wheel equipped cages, plasma TNF-α changes after the same dose lead administrations were not significant. The data are presented as means ± S.E.M. TNF-α: tumor necrosis factor-α; Sed Co: sedentary control group; Ex: exercise group.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3814097&req=5

fig5: Plasma tumor necrosis factor-α in sedentary control and exercise groups before and after lead administrations. Seven days of lead injections (15 mg/Kg body weight, ip) to sedentary animals housed in the regular cages caused significant increase of plasma TNF-α (*P < 0.05 compared to the “before lead administration”); in Ex animals housed in the wheel equipped cages, plasma TNF-α changes after the same dose lead administrations were not significant. The data are presented as means ± S.E.M. TNF-α: tumor necrosis factor-α; Sed Co: sedentary control group; Ex: exercise group.
Mentions: Mean plasma TNF-α level was significantly increased after 7 days of lead injections in sedentary control group but in exercise group TNF-α did not significantly change after lead administration (Figure 5).

Bottom Line: Glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA), and tumor necrosis factor (TNF-α) were measured in the samples.Our results showed that lead administration reduced blood SOD, GPx and CAT and increased TNF-α; in the controls, but in the exercise group, changes were not statistically significant.MDA in both groups increased after lead injections but it was significantly lower in exercise group compared to the sedentary animals.

View Article: PubMed Central - PubMed

Affiliation: Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz 51656-65811, Iran.

ABSTRACT
Regular mild exercise enhances antioxidant and anti-inflammatory systems of the body. The present study investigates voluntary exercise effects on lead toxicity as a known oxidative stressor. Male Sprague-Dawley rats were randomly divided into 2 groups. Sedentary control: the animals were housed 7 weeks in the regular cages. Exercise group: the animals were housed 7 weeks in the running wheel equipped cages, that is, the animal model of voluntary exercise. During the 7th week, all animals were administered lead acetate. Blood samples were collected at the end of the 6th week and 7th week (before and after lead administrations). Glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA), and tumor necrosis factor (TNF-α) were measured in the samples. Our results showed that lead administration reduced blood SOD, GPx and CAT and increased TNF-α; in the controls, but in the exercise group, changes were not statistically significant. MDA in both groups increased after lead injections but it was significantly lower in exercise group compared to the sedentary animals. We concluded that voluntary exercise may be considered as a preventive tool against lead-induced oxidative stress and inflammation.

Show MeSH
Related in: MedlinePlus