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Cyclin D1 G870A polymorphism and risk of nasopharyngeal carcinoma: a meta-analysis.

Li M, Dai W, Zhou H - ScientificWorldJournal (2013)

Bottom Line: However, the results of previous reports remain controversial and ambiguous.In summary, positive results have been shown on the search for polymorphic variants influencing the risk of NPC.Since the results of our meta-analysis are preliminary and may be biased by the relatively small number of subjects, they still need to be validated by well-designed studies using larger samples in the future.

View Article: PubMed Central - PubMed

Affiliation: Department of Laboratory Medicine, Zhejiang Hospital, Hangzhou 310013, China ; Zhejiang Provincial Key Lab of Geriatrics, Hangzhou 310013, China.

ABSTRACT
Recently, there have been a number of studies on the association between cyclin D1 G870A polymorphism and nasopharyngeal carcinoma risk. However, the results of previous reports remain controversial and ambiguous. Thus, we performed a meta-analysis to explore more precisely the association between cyclin D1 G870A polymorphism and the risk of nasopharyngeal carcinoma. No significant association was found between cyclin D1 G870A polymorphism and nasopharyngeal carcinoma risk in total population analysis. In the subgroup meta-analysis by ethnicity, a negative association was shown in Caucasian subgroup, and no significant association in any genetic models among Asians was observed. In summary, positive results have been shown on the search for polymorphic variants influencing the risk of NPC. This meta-analysis provides evidence of the association between CCND1 G870A polymorphism and NPC risk, supporting the hypothesis that CCND1 870A allele probably acts as an important NPC protective factor in Caucasians but not in Asians. Since the results of our meta-analysis are preliminary and may be biased by the relatively small number of subjects, they still need to be validated by well-designed studies using larger samples in the future.

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Related in: MedlinePlus

Forest plots of cyclin D1 G870A polymorphism in nasopharyngeal carcinoma versus normal control and subgroup analyses for A genotype compared with G genotype. The squares and horizontal lines correspond to the study specific OR and 95% CI. The area of the squares reflects the weight (inverse of the variance). The diamond represents the summary OR and 95% CI. OR: odds ratio.
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fig2: Forest plots of cyclin D1 G870A polymorphism in nasopharyngeal carcinoma versus normal control and subgroup analyses for A genotype compared with G genotype. The squares and horizontal lines correspond to the study specific OR and 95% CI. The area of the squares reflects the weight (inverse of the variance). The diamond represents the summary OR and 95% CI. OR: odds ratio.

Mentions: The results on the association between cyclin D1 G870A polymorphism and NPC risk and the heterogeneity test were shown in Table 2. The combined results based on all studies showed that the variant genotypes were not associated with the increased NPC risk in different genetic models (OR = 1.010, 95% CI = 0.628–1.622 for A versus G, P = 0.969; OR = 0.976, 95% CI = 0.368–2.592 for homozygote comparison model AA versus GG, P = 0.961; OR = 0.811, 95% CI = 0.460–1.429 for heterozygote comparison model GA versus GG, P = 0.469; OR = 0.856, 95% CI = 0.430–1.707 for dominant model GA + AA versus GG, P = 0.660) (Figures 2, 3, 4, and 5). In the subgroup analysis by ethnicity, the results revealed a significant association between the cyclin D1 G870A polymorphism and NPC in Caucasian population (A versus G: OR = 0.754, 95% CI = 0.589–0.967, P = 0.026, Phet = 0.989; homozygote comparison model AA versus GG: OR = 0.524, 95% CI = 0.317–0.865, P = 0.011, Phet = 0.968; heterozygote comparison model GA versus GG: OR = 0.467, 95% CI = 0.299–0.730, P = 0.001, Phet = 0.730; dominant model GA + AA versus GG: OR = 0.487, 95% CI = 0.319–0.741, P = 0.001, Phet = 0.804). In contrast, no such significant association in any genetic models was observed in Asians (A versus G: OR = 1.221, 95% CI = 0.647–2.304, P = 0.538; homozygote comparison model AA versus GG: OR = 1.475, 95% CI = 0.407–5.345, P = 0.554; heterozygote comparison model GA versus GG: OR = 1.236, 95% CI = 0.791–1.913, P = 0.554; dominant model GA + AA versus GG: OR = 1.277, 95% CI = 0.631–2.584, P = 0.497).


Cyclin D1 G870A polymorphism and risk of nasopharyngeal carcinoma: a meta-analysis.

Li M, Dai W, Zhou H - ScientificWorldJournal (2013)

Forest plots of cyclin D1 G870A polymorphism in nasopharyngeal carcinoma versus normal control and subgroup analyses for A genotype compared with G genotype. The squares and horizontal lines correspond to the study specific OR and 95% CI. The area of the squares reflects the weight (inverse of the variance). The diamond represents the summary OR and 95% CI. OR: odds ratio.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3814096&req=5

fig2: Forest plots of cyclin D1 G870A polymorphism in nasopharyngeal carcinoma versus normal control and subgroup analyses for A genotype compared with G genotype. The squares and horizontal lines correspond to the study specific OR and 95% CI. The area of the squares reflects the weight (inverse of the variance). The diamond represents the summary OR and 95% CI. OR: odds ratio.
Mentions: The results on the association between cyclin D1 G870A polymorphism and NPC risk and the heterogeneity test were shown in Table 2. The combined results based on all studies showed that the variant genotypes were not associated with the increased NPC risk in different genetic models (OR = 1.010, 95% CI = 0.628–1.622 for A versus G, P = 0.969; OR = 0.976, 95% CI = 0.368–2.592 for homozygote comparison model AA versus GG, P = 0.961; OR = 0.811, 95% CI = 0.460–1.429 for heterozygote comparison model GA versus GG, P = 0.469; OR = 0.856, 95% CI = 0.430–1.707 for dominant model GA + AA versus GG, P = 0.660) (Figures 2, 3, 4, and 5). In the subgroup analysis by ethnicity, the results revealed a significant association between the cyclin D1 G870A polymorphism and NPC in Caucasian population (A versus G: OR = 0.754, 95% CI = 0.589–0.967, P = 0.026, Phet = 0.989; homozygote comparison model AA versus GG: OR = 0.524, 95% CI = 0.317–0.865, P = 0.011, Phet = 0.968; heterozygote comparison model GA versus GG: OR = 0.467, 95% CI = 0.299–0.730, P = 0.001, Phet = 0.730; dominant model GA + AA versus GG: OR = 0.487, 95% CI = 0.319–0.741, P = 0.001, Phet = 0.804). In contrast, no such significant association in any genetic models was observed in Asians (A versus G: OR = 1.221, 95% CI = 0.647–2.304, P = 0.538; homozygote comparison model AA versus GG: OR = 1.475, 95% CI = 0.407–5.345, P = 0.554; heterozygote comparison model GA versus GG: OR = 1.236, 95% CI = 0.791–1.913, P = 0.554; dominant model GA + AA versus GG: OR = 1.277, 95% CI = 0.631–2.584, P = 0.497).

Bottom Line: However, the results of previous reports remain controversial and ambiguous.In summary, positive results have been shown on the search for polymorphic variants influencing the risk of NPC.Since the results of our meta-analysis are preliminary and may be biased by the relatively small number of subjects, they still need to be validated by well-designed studies using larger samples in the future.

View Article: PubMed Central - PubMed

Affiliation: Department of Laboratory Medicine, Zhejiang Hospital, Hangzhou 310013, China ; Zhejiang Provincial Key Lab of Geriatrics, Hangzhou 310013, China.

ABSTRACT
Recently, there have been a number of studies on the association between cyclin D1 G870A polymorphism and nasopharyngeal carcinoma risk. However, the results of previous reports remain controversial and ambiguous. Thus, we performed a meta-analysis to explore more precisely the association between cyclin D1 G870A polymorphism and the risk of nasopharyngeal carcinoma. No significant association was found between cyclin D1 G870A polymorphism and nasopharyngeal carcinoma risk in total population analysis. In the subgroup meta-analysis by ethnicity, a negative association was shown in Caucasian subgroup, and no significant association in any genetic models among Asians was observed. In summary, positive results have been shown on the search for polymorphic variants influencing the risk of NPC. This meta-analysis provides evidence of the association between CCND1 G870A polymorphism and NPC risk, supporting the hypothesis that CCND1 870A allele probably acts as an important NPC protective factor in Caucasians but not in Asians. Since the results of our meta-analysis are preliminary and may be biased by the relatively small number of subjects, they still need to be validated by well-designed studies using larger samples in the future.

Show MeSH
Related in: MedlinePlus