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Cyclin D1 G870A polymorphism and risk of nasopharyngeal carcinoma: a meta-analysis.

Li M, Dai W, Zhou H - ScientificWorldJournal (2013)

Bottom Line: However, the results of previous reports remain controversial and ambiguous.In summary, positive results have been shown on the search for polymorphic variants influencing the risk of NPC.Since the results of our meta-analysis are preliminary and may be biased by the relatively small number of subjects, they still need to be validated by well-designed studies using larger samples in the future.

View Article: PubMed Central - PubMed

Affiliation: Department of Laboratory Medicine, Zhejiang Hospital, Hangzhou 310013, China ; Zhejiang Provincial Key Lab of Geriatrics, Hangzhou 310013, China.

ABSTRACT
Recently, there have been a number of studies on the association between cyclin D1 G870A polymorphism and nasopharyngeal carcinoma risk. However, the results of previous reports remain controversial and ambiguous. Thus, we performed a meta-analysis to explore more precisely the association between cyclin D1 G870A polymorphism and the risk of nasopharyngeal carcinoma. No significant association was found between cyclin D1 G870A polymorphism and nasopharyngeal carcinoma risk in total population analysis. In the subgroup meta-analysis by ethnicity, a negative association was shown in Caucasian subgroup, and no significant association in any genetic models among Asians was observed. In summary, positive results have been shown on the search for polymorphic variants influencing the risk of NPC. This meta-analysis provides evidence of the association between CCND1 G870A polymorphism and NPC risk, supporting the hypothesis that CCND1 870A allele probably acts as an important NPC protective factor in Caucasians but not in Asians. Since the results of our meta-analysis are preliminary and may be biased by the relatively small number of subjects, they still need to be validated by well-designed studies using larger samples in the future.

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Related in: MedlinePlus

Flow chart of study selection based on the inclusion and exclusion criteria.
© Copyright Policy - open-access
Related In: Results  -  Collection


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fig1: Flow chart of study selection based on the inclusion and exclusion criteria.

Mentions: As shown in Figure 1, through the literature search, we have identified 58 potentially relevant papers. After a careful review, 32 papers were excluded because of obvious irrelevance by evaluating the contents of abstracts. In addition, two reviews [5, 7] and nine papers [8–16] which assessed the association between polymorphism and overall head and neck cancers were excluded. Finally, five studies (including 679 cases and 973 controls) studying the cyclin D1 G870A polymorphisms [17–21] met the inclusion criteria and were selected for the meta-analysis.


Cyclin D1 G870A polymorphism and risk of nasopharyngeal carcinoma: a meta-analysis.

Li M, Dai W, Zhou H - ScientificWorldJournal (2013)

Flow chart of study selection based on the inclusion and exclusion criteria.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3814096&req=5

fig1: Flow chart of study selection based on the inclusion and exclusion criteria.
Mentions: As shown in Figure 1, through the literature search, we have identified 58 potentially relevant papers. After a careful review, 32 papers were excluded because of obvious irrelevance by evaluating the contents of abstracts. In addition, two reviews [5, 7] and nine papers [8–16] which assessed the association between polymorphism and overall head and neck cancers were excluded. Finally, five studies (including 679 cases and 973 controls) studying the cyclin D1 G870A polymorphisms [17–21] met the inclusion criteria and were selected for the meta-analysis.

Bottom Line: However, the results of previous reports remain controversial and ambiguous.In summary, positive results have been shown on the search for polymorphic variants influencing the risk of NPC.Since the results of our meta-analysis are preliminary and may be biased by the relatively small number of subjects, they still need to be validated by well-designed studies using larger samples in the future.

View Article: PubMed Central - PubMed

Affiliation: Department of Laboratory Medicine, Zhejiang Hospital, Hangzhou 310013, China ; Zhejiang Provincial Key Lab of Geriatrics, Hangzhou 310013, China.

ABSTRACT
Recently, there have been a number of studies on the association between cyclin D1 G870A polymorphism and nasopharyngeal carcinoma risk. However, the results of previous reports remain controversial and ambiguous. Thus, we performed a meta-analysis to explore more precisely the association between cyclin D1 G870A polymorphism and the risk of nasopharyngeal carcinoma. No significant association was found between cyclin D1 G870A polymorphism and nasopharyngeal carcinoma risk in total population analysis. In the subgroup meta-analysis by ethnicity, a negative association was shown in Caucasian subgroup, and no significant association in any genetic models among Asians was observed. In summary, positive results have been shown on the search for polymorphic variants influencing the risk of NPC. This meta-analysis provides evidence of the association between CCND1 G870A polymorphism and NPC risk, supporting the hypothesis that CCND1 870A allele probably acts as an important NPC protective factor in Caucasians but not in Asians. Since the results of our meta-analysis are preliminary and may be biased by the relatively small number of subjects, they still need to be validated by well-designed studies using larger samples in the future.

Show MeSH
Related in: MedlinePlus