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A numerical study to compare stimulations by intraoperative microelectrodes and chronic macroelectrodes in the DBS technique.

Paffi A, Apollonio F, Puxeddu MG, Parazzini M, d'Inzeo G, Ravazzani P, Liberti M - Biomed Res Int (2013)

Bottom Line: Deep brain stimulation is a clinical technique for the treatment of parkinson's disease based on the electric stimulation, through an implanted electrode, of specific basal ganglia in the brain.Here, we used numerical simulations to predict the stimulation of neuronal fibers induced by microelectrodes and macroelectrodes placed in different positions with respect to each other.Otherwise, some groups of fibers may experience a completely different electric stimulation.

View Article: PubMed Central - PubMed

Affiliation: Department of Information Engineering, Electronics and Telecommunication, Sapienza University of Rome, 00184 Rome, Italy ; Italian Inter-University Center for the Study of Electromagnetic Fields and Biological Systems (ICEmB), 16145 Genova, Italy.

ABSTRACT
Deep brain stimulation is a clinical technique for the treatment of parkinson's disease based on the electric stimulation, through an implanted electrode, of specific basal ganglia in the brain. To identify the correct target of stimulation and to choose the optimal parameters for the stimulating signal, intraoperative microelectrodes are generally used. However, when they are replaced with the chronic macroelectrode, the effect of the stimulation is often very different. Here, we used numerical simulations to predict the stimulation of neuronal fibers induced by microelectrodes and macroelectrodes placed in different positions with respect to each other. Results indicate that comparable stimulations can be obtained if the chronic macroelectrode is correctly positioned with the same electric center of the intraoperative microelectrode. Otherwise, some groups of fibers may experience a completely different electric stimulation.

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(a) Electric potential V along the 3rd line (L3) under the stimulations with the macroelectrode, the microelectrode in position 1, and the microelectrode in position 2; (b) electric potential V along the 11th line (L11) under the stimulations with the macroelectrode, the microelectrode in position 1, and the microelectrode in position 2.
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fig5: (a) Electric potential V along the 3rd line (L3) under the stimulations with the macroelectrode, the microelectrode in position 1, and the microelectrode in position 2; (b) electric potential V along the 11th line (L11) under the stimulations with the macroelectrode, the microelectrode in position 1, and the microelectrode in position 2.

Mentions: The values of V and AF along all the 12 lines have been calculated for the three considered stimulation conditions: macroelectrode, microelectrode in position 1 and microelectrode in position 2 (Figure 3). In Figure 5, the electric potential V is reported along the 3rd line (Figure 5(a)), belonging to the group L1–7, and the 11th line (Figure 5(b)), belonging to the group L8–12, for the three kinds of stimulation. Looking at Figure 5(a), one can see that V is always positive, independently on the kind of stimulation; indeed, due to its position with respect to the active contacts, the 3rd fiber (L3) is always affected by the anodic stimulation. Conversely, the maximum values reached by V along the line are different and essentially depend on the distance between the fiber and the anode. Therefore, although the electric potential on the surfaces of the microelectrode anode is 1000 times higher than on the macroelectrode one (see Section 2.2), the higher distance of the line from the anode makes the values of V lower with the microelectrode stimulation, especially when it is placed laterally (position 2, Figure 3). Similar behaviors are obtained for all the lines of the group L1–7.


A numerical study to compare stimulations by intraoperative microelectrodes and chronic macroelectrodes in the DBS technique.

Paffi A, Apollonio F, Puxeddu MG, Parazzini M, d'Inzeo G, Ravazzani P, Liberti M - Biomed Res Int (2013)

(a) Electric potential V along the 3rd line (L3) under the stimulations with the macroelectrode, the microelectrode in position 1, and the microelectrode in position 2; (b) electric potential V along the 11th line (L11) under the stimulations with the macroelectrode, the microelectrode in position 1, and the microelectrode in position 2.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3814092&req=5

fig5: (a) Electric potential V along the 3rd line (L3) under the stimulations with the macroelectrode, the microelectrode in position 1, and the microelectrode in position 2; (b) electric potential V along the 11th line (L11) under the stimulations with the macroelectrode, the microelectrode in position 1, and the microelectrode in position 2.
Mentions: The values of V and AF along all the 12 lines have been calculated for the three considered stimulation conditions: macroelectrode, microelectrode in position 1 and microelectrode in position 2 (Figure 3). In Figure 5, the electric potential V is reported along the 3rd line (Figure 5(a)), belonging to the group L1–7, and the 11th line (Figure 5(b)), belonging to the group L8–12, for the three kinds of stimulation. Looking at Figure 5(a), one can see that V is always positive, independently on the kind of stimulation; indeed, due to its position with respect to the active contacts, the 3rd fiber (L3) is always affected by the anodic stimulation. Conversely, the maximum values reached by V along the line are different and essentially depend on the distance between the fiber and the anode. Therefore, although the electric potential on the surfaces of the microelectrode anode is 1000 times higher than on the macroelectrode one (see Section 2.2), the higher distance of the line from the anode makes the values of V lower with the microelectrode stimulation, especially when it is placed laterally (position 2, Figure 3). Similar behaviors are obtained for all the lines of the group L1–7.

Bottom Line: Deep brain stimulation is a clinical technique for the treatment of parkinson's disease based on the electric stimulation, through an implanted electrode, of specific basal ganglia in the brain.Here, we used numerical simulations to predict the stimulation of neuronal fibers induced by microelectrodes and macroelectrodes placed in different positions with respect to each other.Otherwise, some groups of fibers may experience a completely different electric stimulation.

View Article: PubMed Central - PubMed

Affiliation: Department of Information Engineering, Electronics and Telecommunication, Sapienza University of Rome, 00184 Rome, Italy ; Italian Inter-University Center for the Study of Electromagnetic Fields and Biological Systems (ICEmB), 16145 Genova, Italy.

ABSTRACT
Deep brain stimulation is a clinical technique for the treatment of parkinson's disease based on the electric stimulation, through an implanted electrode, of specific basal ganglia in the brain. To identify the correct target of stimulation and to choose the optimal parameters for the stimulating signal, intraoperative microelectrodes are generally used. However, when they are replaced with the chronic macroelectrode, the effect of the stimulation is often very different. Here, we used numerical simulations to predict the stimulation of neuronal fibers induced by microelectrodes and macroelectrodes placed in different positions with respect to each other. Results indicate that comparable stimulations can be obtained if the chronic macroelectrode is correctly positioned with the same electric center of the intraoperative microelectrode. Otherwise, some groups of fibers may experience a completely different electric stimulation.

Show MeSH
Related in: MedlinePlus