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A numerical study to compare stimulations by intraoperative microelectrodes and chronic macroelectrodes in the DBS technique.

Paffi A, Apollonio F, Puxeddu MG, Parazzini M, d'Inzeo G, Ravazzani P, Liberti M - Biomed Res Int (2013)

Bottom Line: Deep brain stimulation is a clinical technique for the treatment of parkinson's disease based on the electric stimulation, through an implanted electrode, of specific basal ganglia in the brain.Here, we used numerical simulations to predict the stimulation of neuronal fibers induced by microelectrodes and macroelectrodes placed in different positions with respect to each other.Otherwise, some groups of fibers may experience a completely different electric stimulation.

View Article: PubMed Central - PubMed

Affiliation: Department of Information Engineering, Electronics and Telecommunication, Sapienza University of Rome, 00184 Rome, Italy ; Italian Inter-University Center for the Study of Electromagnetic Fields and Biological Systems (ICEmB), 16145 Genova, Italy.

ABSTRACT
Deep brain stimulation is a clinical technique for the treatment of parkinson's disease based on the electric stimulation, through an implanted electrode, of specific basal ganglia in the brain. To identify the correct target of stimulation and to choose the optimal parameters for the stimulating signal, intraoperative microelectrodes are generally used. However, when they are replaced with the chronic macroelectrode, the effect of the stimulation is often very different. Here, we used numerical simulations to predict the stimulation of neuronal fibers induced by microelectrodes and macroelectrodes placed in different positions with respect to each other. Results indicate that comparable stimulations can be obtained if the chronic macroelectrode is correctly positioned with the same electric center of the intraoperative microelectrode. Otherwise, some groups of fibers may experience a completely different electric stimulation.

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Distribution of the electric potential V induced by the macroelectrode on a plane parallel to xz. The projections of the 12 lines on the plane are highlighted. Among them, two groups have been identified: L1–7, passing closer to the anode; L8–12, passing closer to the cathode.
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fig4: Distribution of the electric potential V induced by the macroelectrode on a plane parallel to xz. The projections of the 12 lines on the plane are highlighted. Among them, two groups have been identified: L1–7, passing closer to the anode; L8–12, passing closer to the cathode.

Mentions: As a first result, Figure 4 reports that the V distribution is induced by the macroelectrode on a plane parallel to the xz one. As evident, the stimulation is mainly confined within the STN, but a spread into the IC is observable, especially in correspondence to the anode, along the anisotropy, that is, the z axis.


A numerical study to compare stimulations by intraoperative microelectrodes and chronic macroelectrodes in the DBS technique.

Paffi A, Apollonio F, Puxeddu MG, Parazzini M, d'Inzeo G, Ravazzani P, Liberti M - Biomed Res Int (2013)

Distribution of the electric potential V induced by the macroelectrode on a plane parallel to xz. The projections of the 12 lines on the plane are highlighted. Among them, two groups have been identified: L1–7, passing closer to the anode; L8–12, passing closer to the cathode.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3814092&req=5

fig4: Distribution of the electric potential V induced by the macroelectrode on a plane parallel to xz. The projections of the 12 lines on the plane are highlighted. Among them, two groups have been identified: L1–7, passing closer to the anode; L8–12, passing closer to the cathode.
Mentions: As a first result, Figure 4 reports that the V distribution is induced by the macroelectrode on a plane parallel to the xz one. As evident, the stimulation is mainly confined within the STN, but a spread into the IC is observable, especially in correspondence to the anode, along the anisotropy, that is, the z axis.

Bottom Line: Deep brain stimulation is a clinical technique for the treatment of parkinson's disease based on the electric stimulation, through an implanted electrode, of specific basal ganglia in the brain.Here, we used numerical simulations to predict the stimulation of neuronal fibers induced by microelectrodes and macroelectrodes placed in different positions with respect to each other.Otherwise, some groups of fibers may experience a completely different electric stimulation.

View Article: PubMed Central - PubMed

Affiliation: Department of Information Engineering, Electronics and Telecommunication, Sapienza University of Rome, 00184 Rome, Italy ; Italian Inter-University Center for the Study of Electromagnetic Fields and Biological Systems (ICEmB), 16145 Genova, Italy.

ABSTRACT
Deep brain stimulation is a clinical technique for the treatment of parkinson's disease based on the electric stimulation, through an implanted electrode, of specific basal ganglia in the brain. To identify the correct target of stimulation and to choose the optimal parameters for the stimulating signal, intraoperative microelectrodes are generally used. However, when they are replaced with the chronic macroelectrode, the effect of the stimulation is often very different. Here, we used numerical simulations to predict the stimulation of neuronal fibers induced by microelectrodes and macroelectrodes placed in different positions with respect to each other. Results indicate that comparable stimulations can be obtained if the chronic macroelectrode is correctly positioned with the same electric center of the intraoperative microelectrode. Otherwise, some groups of fibers may experience a completely different electric stimulation.

Show MeSH
Related in: MedlinePlus