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Activin A and follistatin as biomarkers for ectopic pregnancy and missed abortion.

Daponte A, Deligeoroglou E, Garas A, Pournaras S, Hadjichristodoulou C, Messinis IE - Dis. Markers (2013)

Bottom Line: We assessed whether a single serum measurement of the two physiological antagonists at 6-8 weeks gestation could differentiate ectopic pregnancies (EP) or missed abortions (MA) from healthy intrauterine pregnancies (IUP). activin A concentrations were significantly lower in women with EP (n = 30, median value of 264 pg/mL) and women with MA (n = 30, median value of 350 pg/mL) compared to IUP (n = 33, median value of 788 pg/mL); P < 0.001.In EP, activin A did not correlate with beta HCG levels.The present findings support the thesis that activin A or FS could be considered promising biomarkers for the discrimination between an IUP and a failed pregnancy (MA or EP).

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41110 Biopolis, Larissa, Greece.

ABSTRACT
Activin A as a predictor of pregnancy failure has been the focus of heated debate, but the value of a combined activin A and follistatin (FS) measurement in serum to predict pregnancy failure has not been reported yet. We assessed whether a single serum measurement of the two physiological antagonists at 6-8 weeks gestation could differentiate ectopic pregnancies (EP) or missed abortions (MA) from healthy intrauterine pregnancies (IUP). activin A concentrations were significantly lower in women with EP (n = 30, median value of 264 pg/mL) and women with MA (n = 30, median value of 350 pg/mL) compared to IUP (n = 33, median value of 788 pg/mL); P < 0.001. At a threshold value of 505 pg/mL, activin A had 87.9% sensitivity and 100% specificity and negative predictive value of 0.974 for discriminating an ectopic pregnancy from viable pregnancies. FS was able to discriminate IUP from EP (ROC curve P < 0.001) as was their ratio (ROC curve P = 0.008), but was unable to discriminate a MA from an EP. In EP, activin A did not correlate with beta HCG levels. The present findings support the thesis that activin A or FS could be considered promising biomarkers for the discrimination between an IUP and a failed pregnancy (MA or EP).

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Related in: MedlinePlus

Scatter plot diagram for the distribution of (a) activin A, (b) follistatin, and (c) activin A/follistatin ratio values according to the pregnancy outcome (viable intrauterine pregnancy (IUP), missed abortion (MA), and ectopic pregnancy (EP)).
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Related In: Results  -  Collection


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fig1: Scatter plot diagram for the distribution of (a) activin A, (b) follistatin, and (c) activin A/follistatin ratio values according to the pregnancy outcome (viable intrauterine pregnancy (IUP), missed abortion (MA), and ectopic pregnancy (EP)).

Mentions: A summary of the results of serum activin A and FS is given in Tables 1–3 and Figures 1 and 2.


Activin A and follistatin as biomarkers for ectopic pregnancy and missed abortion.

Daponte A, Deligeoroglou E, Garas A, Pournaras S, Hadjichristodoulou C, Messinis IE - Dis. Markers (2013)

Scatter plot diagram for the distribution of (a) activin A, (b) follistatin, and (c) activin A/follistatin ratio values according to the pregnancy outcome (viable intrauterine pregnancy (IUP), missed abortion (MA), and ectopic pregnancy (EP)).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3814079&req=5

fig1: Scatter plot diagram for the distribution of (a) activin A, (b) follistatin, and (c) activin A/follistatin ratio values according to the pregnancy outcome (viable intrauterine pregnancy (IUP), missed abortion (MA), and ectopic pregnancy (EP)).
Mentions: A summary of the results of serum activin A and FS is given in Tables 1–3 and Figures 1 and 2.

Bottom Line: We assessed whether a single serum measurement of the two physiological antagonists at 6-8 weeks gestation could differentiate ectopic pregnancies (EP) or missed abortions (MA) from healthy intrauterine pregnancies (IUP). activin A concentrations were significantly lower in women with EP (n = 30, median value of 264 pg/mL) and women with MA (n = 30, median value of 350 pg/mL) compared to IUP (n = 33, median value of 788 pg/mL); P < 0.001.In EP, activin A did not correlate with beta HCG levels.The present findings support the thesis that activin A or FS could be considered promising biomarkers for the discrimination between an IUP and a failed pregnancy (MA or EP).

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41110 Biopolis, Larissa, Greece.

ABSTRACT
Activin A as a predictor of pregnancy failure has been the focus of heated debate, but the value of a combined activin A and follistatin (FS) measurement in serum to predict pregnancy failure has not been reported yet. We assessed whether a single serum measurement of the two physiological antagonists at 6-8 weeks gestation could differentiate ectopic pregnancies (EP) or missed abortions (MA) from healthy intrauterine pregnancies (IUP). activin A concentrations were significantly lower in women with EP (n = 30, median value of 264 pg/mL) and women with MA (n = 30, median value of 350 pg/mL) compared to IUP (n = 33, median value of 788 pg/mL); P < 0.001. At a threshold value of 505 pg/mL, activin A had 87.9% sensitivity and 100% specificity and negative predictive value of 0.974 for discriminating an ectopic pregnancy from viable pregnancies. FS was able to discriminate IUP from EP (ROC curve P < 0.001) as was their ratio (ROC curve P = 0.008), but was unable to discriminate a MA from an EP. In EP, activin A did not correlate with beta HCG levels. The present findings support the thesis that activin A or FS could be considered promising biomarkers for the discrimination between an IUP and a failed pregnancy (MA or EP).

Show MeSH
Related in: MedlinePlus