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Molecular imaging in traditional Chinese medicine therapy for neurological diseases.

Wang Z, Wan H, Li J, Zhang H, Tian M - Biomed Res Int (2013)

Bottom Line: With the speeding tendency of aging society, human neurological disorders have posed an ever increasing threat to public health care.Currently, there are no more effective treatments against these diseases.Traditional Chinese medicine (TCM) is focused on, which can provide new strategies for the therapy in neurological disorders.

View Article: PubMed Central - PubMed

Affiliation: Department of Nuclear Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, Zhejiang 310009, China ; Zhejiang University Medical PET Center, Zhejiang University, Hangzhou 310009, China ; Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou 310009, China ; Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou 310009, China ; Institute of Cardiocerbrovascular Diseases, Zhejiang Chinese Medical University, Hangzhou 310053, China.

ABSTRACT
With the speeding tendency of aging society, human neurological disorders have posed an ever increasing threat to public health care. Human neurological diseases include ischemic brain injury, Alzheimer's disease, Parkinson's disease, and spinal cord injury, which are induced by impairment or specific degeneration of different types of neurons in central nervous system. Currently, there are no more effective treatments against these diseases. Traditional Chinese medicine (TCM) is focused on, which can provide new strategies for the therapy in neurological disorders. TCM, including Chinese herb medicine, acupuncture, and other nonmedication therapies, has its unique therapies in treating neurological diseases. In order to improve the treatment of these disorders by optimizing strategies using TCM and evaluate the therapeutic effects, we have summarized molecular imaging, a new promising technology, to assess noninvasively disease specific in cellular and molecular levels of living models in vivo, that was applied in TCM therapy for neurological diseases. In this review, we mainly focus on applying diverse molecular imaging methodologies in different TCM therapies and monitoring neurological disease, and unveiling the mysteries of TCM.

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Related in: MedlinePlus

[123I]IBZM-SPECT images of the acupuncture-treated MPTP-induced Parkinson's disease mice. The left is sham acupuncture (SA) group, and the right is retained acupuncture (RA) group. The intensity of radionuclide or radiopharmaceutical uptake in RA group is higher than that in SA group [65].
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fig3: [123I]IBZM-SPECT images of the acupuncture-treated MPTP-induced Parkinson's disease mice. The left is sham acupuncture (SA) group, and the right is retained acupuncture (RA) group. The intensity of radionuclide or radiopharmaceutical uptake in RA group is higher than that in SA group [65].

Mentions: SPECT is a technique that uses a tracer to acquire images that reflect fundamental biophysiologic functions of perfusion and metabolism in different body organs, by analysing the temporal changes of radionuclide concentration in tomographic sections through angular sampling of projections [63]. SPECT was used to reveal the effect of acupuncture in treatment of PD patients or PD animal models. Huang et al. [64] investigated cerebral effects of complementary acupuncture in PD patients by using SPECT with 99mTc-ECD and 99mTc-TRODAT-4, both before and after five weeks of treatment. The result showed that combination acupuncture and levodopa increased regional cerebral blood flow (rCBF) in the frontal lobe, the basal ganglion, the occipital lobe, and the cerebellum in the most affected hemisphere as compared with baseline, whereas there were no changes in basal ganglia dopamine transporter (DAT) levels. Thus, complementary acupuncture treatment in PD may affect rCBF but not basal ganglion DA. Another study about acupuncture in PD animal modes also used SPECT. Yang et al. [65] investigate the role of retained acupuncture (RA) in neurotoxin-induced PD mice with [123I] IBZM-SPECT imaging. The SPECT imaging showed that the intensity of radionuclide or radiopharmaceutical uptake in RA group is higher than that in sham acupuncture (SA) group (Figure 3). By using quantitative analysis, the peak time of [123I] IBZM uptake was longer than RA group, which suggesting that the delayed kinetic change by MPTP damage could be reversed by RA treatment. Therefore, RA may be useful as a complementary strategy when treating PD.


Molecular imaging in traditional Chinese medicine therapy for neurological diseases.

Wang Z, Wan H, Li J, Zhang H, Tian M - Biomed Res Int (2013)

[123I]IBZM-SPECT images of the acupuncture-treated MPTP-induced Parkinson's disease mice. The left is sham acupuncture (SA) group, and the right is retained acupuncture (RA) group. The intensity of radionuclide or radiopharmaceutical uptake in RA group is higher than that in SA group [65].
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3814075&req=5

fig3: [123I]IBZM-SPECT images of the acupuncture-treated MPTP-induced Parkinson's disease mice. The left is sham acupuncture (SA) group, and the right is retained acupuncture (RA) group. The intensity of radionuclide or radiopharmaceutical uptake in RA group is higher than that in SA group [65].
Mentions: SPECT is a technique that uses a tracer to acquire images that reflect fundamental biophysiologic functions of perfusion and metabolism in different body organs, by analysing the temporal changes of radionuclide concentration in tomographic sections through angular sampling of projections [63]. SPECT was used to reveal the effect of acupuncture in treatment of PD patients or PD animal models. Huang et al. [64] investigated cerebral effects of complementary acupuncture in PD patients by using SPECT with 99mTc-ECD and 99mTc-TRODAT-4, both before and after five weeks of treatment. The result showed that combination acupuncture and levodopa increased regional cerebral blood flow (rCBF) in the frontal lobe, the basal ganglion, the occipital lobe, and the cerebellum in the most affected hemisphere as compared with baseline, whereas there were no changes in basal ganglia dopamine transporter (DAT) levels. Thus, complementary acupuncture treatment in PD may affect rCBF but not basal ganglion DA. Another study about acupuncture in PD animal modes also used SPECT. Yang et al. [65] investigate the role of retained acupuncture (RA) in neurotoxin-induced PD mice with [123I] IBZM-SPECT imaging. The SPECT imaging showed that the intensity of radionuclide or radiopharmaceutical uptake in RA group is higher than that in sham acupuncture (SA) group (Figure 3). By using quantitative analysis, the peak time of [123I] IBZM uptake was longer than RA group, which suggesting that the delayed kinetic change by MPTP damage could be reversed by RA treatment. Therefore, RA may be useful as a complementary strategy when treating PD.

Bottom Line: With the speeding tendency of aging society, human neurological disorders have posed an ever increasing threat to public health care.Currently, there are no more effective treatments against these diseases.Traditional Chinese medicine (TCM) is focused on, which can provide new strategies for the therapy in neurological disorders.

View Article: PubMed Central - PubMed

Affiliation: Department of Nuclear Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, Zhejiang 310009, China ; Zhejiang University Medical PET Center, Zhejiang University, Hangzhou 310009, China ; Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou 310009, China ; Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou 310009, China ; Institute of Cardiocerbrovascular Diseases, Zhejiang Chinese Medical University, Hangzhou 310053, China.

ABSTRACT
With the speeding tendency of aging society, human neurological disorders have posed an ever increasing threat to public health care. Human neurological diseases include ischemic brain injury, Alzheimer's disease, Parkinson's disease, and spinal cord injury, which are induced by impairment or specific degeneration of different types of neurons in central nervous system. Currently, there are no more effective treatments against these diseases. Traditional Chinese medicine (TCM) is focused on, which can provide new strategies for the therapy in neurological disorders. TCM, including Chinese herb medicine, acupuncture, and other nonmedication therapies, has its unique therapies in treating neurological diseases. In order to improve the treatment of these disorders by optimizing strategies using TCM and evaluate the therapeutic effects, we have summarized molecular imaging, a new promising technology, to assess noninvasively disease specific in cellular and molecular levels of living models in vivo, that was applied in TCM therapy for neurological diseases. In this review, we mainly focus on applying diverse molecular imaging methodologies in different TCM therapies and monitoring neurological disease, and unveiling the mysteries of TCM.

Show MeSH
Related in: MedlinePlus