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Molecular imaging in traditional Chinese medicine therapy for neurological diseases.

Wang Z, Wan H, Li J, Zhang H, Tian M - Biomed Res Int (2013)

Bottom Line: With the speeding tendency of aging society, human neurological disorders have posed an ever increasing threat to public health care.Currently, there are no more effective treatments against these diseases.Traditional Chinese medicine (TCM) is focused on, which can provide new strategies for the therapy in neurological disorders.

View Article: PubMed Central - PubMed

Affiliation: Department of Nuclear Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, Zhejiang 310009, China ; Zhejiang University Medical PET Center, Zhejiang University, Hangzhou 310009, China ; Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou 310009, China ; Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou 310009, China ; Institute of Cardiocerbrovascular Diseases, Zhejiang Chinese Medical University, Hangzhou 310053, China.

ABSTRACT
With the speeding tendency of aging society, human neurological disorders have posed an ever increasing threat to public health care. Human neurological diseases include ischemic brain injury, Alzheimer's disease, Parkinson's disease, and spinal cord injury, which are induced by impairment or specific degeneration of different types of neurons in central nervous system. Currently, there are no more effective treatments against these diseases. Traditional Chinese medicine (TCM) is focused on, which can provide new strategies for the therapy in neurological disorders. TCM, including Chinese herb medicine, acupuncture, and other nonmedication therapies, has its unique therapies in treating neurological diseases. In order to improve the treatment of these disorders by optimizing strategies using TCM and evaluate the therapeutic effects, we have summarized molecular imaging, a new promising technology, to assess noninvasively disease specific in cellular and molecular levels of living models in vivo, that was applied in TCM therapy for neurological diseases. In this review, we mainly focus on applying diverse molecular imaging methodologies in different TCM therapies and monitoring neurological disease, and unveiling the mysteries of TCM.

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Related in: MedlinePlus

fMRI images of regions showing increased or decreased activities in entire brain of Alzheimer's disease patients after acupuncture compared with the resting state. Left in picture is left in the brain. The color scale represents t values [60].
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fig2: fMRI images of regions showing increased or decreased activities in entire brain of Alzheimer's disease patients after acupuncture compared with the resting state. Left in picture is left in the brain. The color scale represents t values [60].

Mentions: fMRI was used clinically to investigate the effect and clarify the mechanisms of acupuncture in treating AD. Zhou and Jia [59] explored various regions of the brains of AD patients before and after acupuncture treatment of Shenmen (HT7), Zusanii (ST36), Fenglong (ST40), and Taixi (KI3) acupoints by using fMRI. The result demonstrated that there were left activated regions (temporal lobe, parietal lobule, and some regions of cerebellum) and right main hemisphere activations (temporal lobes, such as hippocampal gyrus, insula, and some area of parietal lobe), both of which were induced by these acupoints. To our surprise, the activated region, closely correlated with the cognitive function, consisted of the impaired areas in brain for AD patients. In order to better understanding of the pathophysiology of AD, Wang et al. [60] attempted to investigate the effect of acupuncture at the acupoints of Tai-chong (Liv3) and Hegu (LI4) in left and right sides on the brain functional activity throughout the entire brain in AD patients compared with normal controls. The result showed the increased activities in the regions of right cerebellum posterior lobe, bilateral frontal lobe, right inferior parietal lobule, and right middle occipital lobe, and the decreased activities in the regions of right superior temporal gyrus, right middle temporal gyrus, bilateral middle frontal gyrus, and left brain stem from that of resting state in the process of acupuncture. Posteffect of the acupuncture was further examined, and the activated regions included the frontal lobe, the occipital lobe, the parietal lobe, and the temporal lobe (Figure 2). They speculated that the temporal lobe, as is subjected to be impaired in AD patients, was activated to compensate for the cognitive impairment. These present studies using fMRI provided the strong evidence that acupuncture had a potential effect on AD.


Molecular imaging in traditional Chinese medicine therapy for neurological diseases.

Wang Z, Wan H, Li J, Zhang H, Tian M - Biomed Res Int (2013)

fMRI images of regions showing increased or decreased activities in entire brain of Alzheimer's disease patients after acupuncture compared with the resting state. Left in picture is left in the brain. The color scale represents t values [60].
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3814075&req=5

fig2: fMRI images of regions showing increased or decreased activities in entire brain of Alzheimer's disease patients after acupuncture compared with the resting state. Left in picture is left in the brain. The color scale represents t values [60].
Mentions: fMRI was used clinically to investigate the effect and clarify the mechanisms of acupuncture in treating AD. Zhou and Jia [59] explored various regions of the brains of AD patients before and after acupuncture treatment of Shenmen (HT7), Zusanii (ST36), Fenglong (ST40), and Taixi (KI3) acupoints by using fMRI. The result demonstrated that there were left activated regions (temporal lobe, parietal lobule, and some regions of cerebellum) and right main hemisphere activations (temporal lobes, such as hippocampal gyrus, insula, and some area of parietal lobe), both of which were induced by these acupoints. To our surprise, the activated region, closely correlated with the cognitive function, consisted of the impaired areas in brain for AD patients. In order to better understanding of the pathophysiology of AD, Wang et al. [60] attempted to investigate the effect of acupuncture at the acupoints of Tai-chong (Liv3) and Hegu (LI4) in left and right sides on the brain functional activity throughout the entire brain in AD patients compared with normal controls. The result showed the increased activities in the regions of right cerebellum posterior lobe, bilateral frontal lobe, right inferior parietal lobule, and right middle occipital lobe, and the decreased activities in the regions of right superior temporal gyrus, right middle temporal gyrus, bilateral middle frontal gyrus, and left brain stem from that of resting state in the process of acupuncture. Posteffect of the acupuncture was further examined, and the activated regions included the frontal lobe, the occipital lobe, the parietal lobe, and the temporal lobe (Figure 2). They speculated that the temporal lobe, as is subjected to be impaired in AD patients, was activated to compensate for the cognitive impairment. These present studies using fMRI provided the strong evidence that acupuncture had a potential effect on AD.

Bottom Line: With the speeding tendency of aging society, human neurological disorders have posed an ever increasing threat to public health care.Currently, there are no more effective treatments against these diseases.Traditional Chinese medicine (TCM) is focused on, which can provide new strategies for the therapy in neurological disorders.

View Article: PubMed Central - PubMed

Affiliation: Department of Nuclear Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, Zhejiang 310009, China ; Zhejiang University Medical PET Center, Zhejiang University, Hangzhou 310009, China ; Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou 310009, China ; Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou 310009, China ; Institute of Cardiocerbrovascular Diseases, Zhejiang Chinese Medical University, Hangzhou 310053, China.

ABSTRACT
With the speeding tendency of aging society, human neurological disorders have posed an ever increasing threat to public health care. Human neurological diseases include ischemic brain injury, Alzheimer's disease, Parkinson's disease, and spinal cord injury, which are induced by impairment or specific degeneration of different types of neurons in central nervous system. Currently, there are no more effective treatments against these diseases. Traditional Chinese medicine (TCM) is focused on, which can provide new strategies for the therapy in neurological disorders. TCM, including Chinese herb medicine, acupuncture, and other nonmedication therapies, has its unique therapies in treating neurological diseases. In order to improve the treatment of these disorders by optimizing strategies using TCM and evaluate the therapeutic effects, we have summarized molecular imaging, a new promising technology, to assess noninvasively disease specific in cellular and molecular levels of living models in vivo, that was applied in TCM therapy for neurological diseases. In this review, we mainly focus on applying diverse molecular imaging methodologies in different TCM therapies and monitoring neurological disease, and unveiling the mysteries of TCM.

Show MeSH
Related in: MedlinePlus