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Molecular imaging in traditional Chinese medicine therapy for neurological diseases.

Wang Z, Wan H, Li J, Zhang H, Tian M - Biomed Res Int (2013)

Bottom Line: With the speeding tendency of aging society, human neurological disorders have posed an ever increasing threat to public health care.Currently, there are no more effective treatments against these diseases.Traditional Chinese medicine (TCM) is focused on, which can provide new strategies for the therapy in neurological disorders.

View Article: PubMed Central - PubMed

Affiliation: Department of Nuclear Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, Zhejiang 310009, China ; Zhejiang University Medical PET Center, Zhejiang University, Hangzhou 310009, China ; Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou 310009, China ; Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou 310009, China ; Institute of Cardiocerbrovascular Diseases, Zhejiang Chinese Medical University, Hangzhou 310053, China.

ABSTRACT
With the speeding tendency of aging society, human neurological disorders have posed an ever increasing threat to public health care. Human neurological diseases include ischemic brain injury, Alzheimer's disease, Parkinson's disease, and spinal cord injury, which are induced by impairment or specific degeneration of different types of neurons in central nervous system. Currently, there are no more effective treatments against these diseases. Traditional Chinese medicine (TCM) is focused on, which can provide new strategies for the therapy in neurological disorders. TCM, including Chinese herb medicine, acupuncture, and other nonmedication therapies, has its unique therapies in treating neurological diseases. In order to improve the treatment of these disorders by optimizing strategies using TCM and evaluate the therapeutic effects, we have summarized molecular imaging, a new promising technology, to assess noninvasively disease specific in cellular and molecular levels of living models in vivo, that was applied in TCM therapy for neurological diseases. In this review, we mainly focus on applying diverse molecular imaging methodologies in different TCM therapies and monitoring neurological disease, and unveiling the mysteries of TCM.

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18F-FDG-PET images of activity of hibateral hippocampus regions glucose metabolism in rats to evaluate the effects both Astragaloside IV (ASG IV) and tetramethylpyrazine (TMPZ) on the cerebral ischemia-reperfusion injury. (a) Sham group, (b) model group, (c) ASG IV group, (d) ASG IV-TMPZ group, and (e) nimodipine group. The glucose metabolism of the ASG IV-TMPZ group was significantly recovered in the right area of cerebrum compared with other groups [31].
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fig1: 18F-FDG-PET images of activity of hibateral hippocampus regions glucose metabolism in rats to evaluate the effects both Astragaloside IV (ASG IV) and tetramethylpyrazine (TMPZ) on the cerebral ischemia-reperfusion injury. (a) Sham group, (b) model group, (c) ASG IV group, (d) ASG IV-TMPZ group, and (e) nimodipine group. The glucose metabolism of the ASG IV-TMPZ group was significantly recovered in the right area of cerebrum compared with other groups [31].

Mentions: Micro-PET has the advantage to monitor the glucose metabolism noninvasively and assess the early effects for cerebrovascular disease therapy [28, 29], and glucose metabolism in the brain is closely related to neuronal activity [30]. Yang et al. [31] used 18F labeled 2-deoxy-2-fluoro-D-glucose (18F-FDG), as an imaging agent that reflects the state of glucose metabolism, to evaluate the effects both Astragaloside IV (ASG IV) and tetramethylpyrazine (TMPZ) on the cerebral ischemia-reperfusion injury by micro-PET. In order to uncover the therapeutic effect quantitatively, the ratio of the regions of interest (ROIs) in the temporal lobe, apical lobe, and frontal lobe to cerebellum was calculated for each group. As a result, glucose metabolism in injury brain while being treated with ASG IV and ASG IV-TMPZ was increased significantly, compared with the model group. Furthermore, glucose metabolism of the ASG IV-TMPZ group was significantly recovered in the right area of cerebrum compared with the single ASG IV group, demonstrating a visible therapeutic effect of ASG IV-TMPZ (Figure 1). Another similar study was conducted by Wan et al. [32]. They used micro-PET with 18F-FDG to monitor the therapeutic response of chuanxiongzine and puerarin in a rat model of transient middle cerebral artery occlusion (MCAO)-induced focal cerebral ischemia. Obvious metabolic asymmetry in the right and left hemispheres of rat after the operation of MCAO was observed, and the right hypometabolic region was enlarged distinctly in the chuanxiongzine and chuanxiongzine-puerarin groups, between which the hypometabolic region in the chuanxiongzine-puerarin group was bigger. This study represented the credible evidence that the effect of chuanxiongzine-puerarin was better than puerarin in the recovery of glucose metabolism and the infarction volume of cerebral IR damage.


Molecular imaging in traditional Chinese medicine therapy for neurological diseases.

Wang Z, Wan H, Li J, Zhang H, Tian M - Biomed Res Int (2013)

18F-FDG-PET images of activity of hibateral hippocampus regions glucose metabolism in rats to evaluate the effects both Astragaloside IV (ASG IV) and tetramethylpyrazine (TMPZ) on the cerebral ischemia-reperfusion injury. (a) Sham group, (b) model group, (c) ASG IV group, (d) ASG IV-TMPZ group, and (e) nimodipine group. The glucose metabolism of the ASG IV-TMPZ group was significantly recovered in the right area of cerebrum compared with other groups [31].
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3814075&req=5

fig1: 18F-FDG-PET images of activity of hibateral hippocampus regions glucose metabolism in rats to evaluate the effects both Astragaloside IV (ASG IV) and tetramethylpyrazine (TMPZ) on the cerebral ischemia-reperfusion injury. (a) Sham group, (b) model group, (c) ASG IV group, (d) ASG IV-TMPZ group, and (e) nimodipine group. The glucose metabolism of the ASG IV-TMPZ group was significantly recovered in the right area of cerebrum compared with other groups [31].
Mentions: Micro-PET has the advantage to monitor the glucose metabolism noninvasively and assess the early effects for cerebrovascular disease therapy [28, 29], and glucose metabolism in the brain is closely related to neuronal activity [30]. Yang et al. [31] used 18F labeled 2-deoxy-2-fluoro-D-glucose (18F-FDG), as an imaging agent that reflects the state of glucose metabolism, to evaluate the effects both Astragaloside IV (ASG IV) and tetramethylpyrazine (TMPZ) on the cerebral ischemia-reperfusion injury by micro-PET. In order to uncover the therapeutic effect quantitatively, the ratio of the regions of interest (ROIs) in the temporal lobe, apical lobe, and frontal lobe to cerebellum was calculated for each group. As a result, glucose metabolism in injury brain while being treated with ASG IV and ASG IV-TMPZ was increased significantly, compared with the model group. Furthermore, glucose metabolism of the ASG IV-TMPZ group was significantly recovered in the right area of cerebrum compared with the single ASG IV group, demonstrating a visible therapeutic effect of ASG IV-TMPZ (Figure 1). Another similar study was conducted by Wan et al. [32]. They used micro-PET with 18F-FDG to monitor the therapeutic response of chuanxiongzine and puerarin in a rat model of transient middle cerebral artery occlusion (MCAO)-induced focal cerebral ischemia. Obvious metabolic asymmetry in the right and left hemispheres of rat after the operation of MCAO was observed, and the right hypometabolic region was enlarged distinctly in the chuanxiongzine and chuanxiongzine-puerarin groups, between which the hypometabolic region in the chuanxiongzine-puerarin group was bigger. This study represented the credible evidence that the effect of chuanxiongzine-puerarin was better than puerarin in the recovery of glucose metabolism and the infarction volume of cerebral IR damage.

Bottom Line: With the speeding tendency of aging society, human neurological disorders have posed an ever increasing threat to public health care.Currently, there are no more effective treatments against these diseases.Traditional Chinese medicine (TCM) is focused on, which can provide new strategies for the therapy in neurological disorders.

View Article: PubMed Central - PubMed

Affiliation: Department of Nuclear Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, Zhejiang 310009, China ; Zhejiang University Medical PET Center, Zhejiang University, Hangzhou 310009, China ; Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou 310009, China ; Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou 310009, China ; Institute of Cardiocerbrovascular Diseases, Zhejiang Chinese Medical University, Hangzhou 310053, China.

ABSTRACT
With the speeding tendency of aging society, human neurological disorders have posed an ever increasing threat to public health care. Human neurological diseases include ischemic brain injury, Alzheimer's disease, Parkinson's disease, and spinal cord injury, which are induced by impairment or specific degeneration of different types of neurons in central nervous system. Currently, there are no more effective treatments against these diseases. Traditional Chinese medicine (TCM) is focused on, which can provide new strategies for the therapy in neurological disorders. TCM, including Chinese herb medicine, acupuncture, and other nonmedication therapies, has its unique therapies in treating neurological diseases. In order to improve the treatment of these disorders by optimizing strategies using TCM and evaluate the therapeutic effects, we have summarized molecular imaging, a new promising technology, to assess noninvasively disease specific in cellular and molecular levels of living models in vivo, that was applied in TCM therapy for neurological diseases. In this review, we mainly focus on applying diverse molecular imaging methodologies in different TCM therapies and monitoring neurological disease, and unveiling the mysteries of TCM.

Show MeSH
Related in: MedlinePlus