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Unusual clinical presentation of cutaneous angiosarcoma masquerading as eczema: a case report and review of the literature.

Trinh NQ, Rashed I, Hutchens KA, Go A, Melian E, Tung R - Case Rep Dermatol Med (2013)

Bottom Line: A 98-year-old Caucasian male presented with a 6-month history of a flesh-colored, subcutaneous nodule on his left forehead with contralateral facial erythema and scaling that had been previously diagnosed as eczema.Despite treatments with topical steroids and moisturizers, the condition did not resolve.It also demonstrates that these lesions may respond well to radiotherapy as a single modality.

View Article: PubMed Central - PubMed

Affiliation: Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153, USA.

ABSTRACT
An unusual case of cutaneous angiosarcoma clinically mimicking eczema is described. A 98-year-old Caucasian male presented with a 6-month history of a flesh-colored, subcutaneous nodule on his left forehead with contralateral facial erythema and scaling that had been previously diagnosed as eczema. Despite treatments with topical steroids and moisturizers, the condition did not resolve. At our clinic, excisional biopsy of the forehead lesion and scouting biopsies from the contralateral cheek were performed which revealed cutaneous angiosarcoma. The described case illustrates that dermatitis-like features should be considered as a rare clinical manifestation of cutaneous angiosarcoma. It also demonstrates that these lesions may respond well to radiotherapy as a single modality.

No MeSH data available.


Related in: MedlinePlus

The main tumor was bulky and composed of atypical and pleomorphic spindle cells with numerous mitotic figures (a). On the periphery of the tumor, areas of vessel formation with hyperchromatic and “hob-nailing” (blue arrow) of the neoplastic endothelium were seen (b).
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fig2: The main tumor was bulky and composed of atypical and pleomorphic spindle cells with numerous mitotic figures (a). On the periphery of the tumor, areas of vessel formation with hyperchromatic and “hob-nailing” (blue arrow) of the neoplastic endothelium were seen (b).

Mentions: On clinical examination, the patient was found to have a flesh-colored subcutaneous nodule measuring 1.5 × 0.9 cm in diameter on his left forehead and poorly demarcated red, scaly patches which were most prominent on the right contralateral cheek (Figure 1). An excisional biopsy was performed, which revealed angiosarcoma with positive lateral and deep margins (Figure 2). Immunohistochemical stains showed that the tumor cells were positive for CD34 and CD31 and negative for S100, LCA, CK7, and CK20. A wider local excision was attempted; however, we were not able to achieve clear margins. The majority of the wound was closed primarily, but the central area was left to heal secondarily.


Unusual clinical presentation of cutaneous angiosarcoma masquerading as eczema: a case report and review of the literature.

Trinh NQ, Rashed I, Hutchens KA, Go A, Melian E, Tung R - Case Rep Dermatol Med (2013)

The main tumor was bulky and composed of atypical and pleomorphic spindle cells with numerous mitotic figures (a). On the periphery of the tumor, areas of vessel formation with hyperchromatic and “hob-nailing” (blue arrow) of the neoplastic endothelium were seen (b).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3814070&req=5

fig2: The main tumor was bulky and composed of atypical and pleomorphic spindle cells with numerous mitotic figures (a). On the periphery of the tumor, areas of vessel formation with hyperchromatic and “hob-nailing” (blue arrow) of the neoplastic endothelium were seen (b).
Mentions: On clinical examination, the patient was found to have a flesh-colored subcutaneous nodule measuring 1.5 × 0.9 cm in diameter on his left forehead and poorly demarcated red, scaly patches which were most prominent on the right contralateral cheek (Figure 1). An excisional biopsy was performed, which revealed angiosarcoma with positive lateral and deep margins (Figure 2). Immunohistochemical stains showed that the tumor cells were positive for CD34 and CD31 and negative for S100, LCA, CK7, and CK20. A wider local excision was attempted; however, we were not able to achieve clear margins. The majority of the wound was closed primarily, but the central area was left to heal secondarily.

Bottom Line: A 98-year-old Caucasian male presented with a 6-month history of a flesh-colored, subcutaneous nodule on his left forehead with contralateral facial erythema and scaling that had been previously diagnosed as eczema.Despite treatments with topical steroids and moisturizers, the condition did not resolve.It also demonstrates that these lesions may respond well to radiotherapy as a single modality.

View Article: PubMed Central - PubMed

Affiliation: Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153, USA.

ABSTRACT
An unusual case of cutaneous angiosarcoma clinically mimicking eczema is described. A 98-year-old Caucasian male presented with a 6-month history of a flesh-colored, subcutaneous nodule on his left forehead with contralateral facial erythema and scaling that had been previously diagnosed as eczema. Despite treatments with topical steroids and moisturizers, the condition did not resolve. At our clinic, excisional biopsy of the forehead lesion and scouting biopsies from the contralateral cheek were performed which revealed cutaneous angiosarcoma. The described case illustrates that dermatitis-like features should be considered as a rare clinical manifestation of cutaneous angiosarcoma. It also demonstrates that these lesions may respond well to radiotherapy as a single modality.

No MeSH data available.


Related in: MedlinePlus