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Fullerenols as a new therapeutic approach in nanomedicine.

Grebowski J, Kazmierska P, Krokosz A - Biomed Res Int (2013)

Bottom Line: Anthracycline therapy, in spite of its effective antitumor activity, induces systemic oxidative stress, which interferes with the effectiveness of the treatment and results in serious side effects.Fullerenols may counteract the harmful effects of anthracyclines by scavenging free radicals and thereby improve the effects of chemotherapy.In the search of alternative methods of treatment and diagnosis, today's science is increasingly reaching for tools in the field of nanomedicine, for example, fullerenes and their water-soluble derivatives, which is addressed in the present paper.

View Article: PubMed Central - PubMed

Affiliation: Department of Molecular Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, ul. Pomorska 141/143, 90-236 Lodz, Poland.

ABSTRACT
Recently, much attention has been paid to the bioactive properties of water-soluble fullerene derivatives: fullerenols, with emphasis on their pro- and antioxidative properties. Due to their hydrophilic properties and the ability to scavenge free radicals, fullerenols may, in the future, provide a serious alternative to the currently used pharmacological methods in chemotherapy, treatment of neurodegenerative diseases, and radiobiology. Some of the most widely used drugs in chemotherapy are anthracycline antibiotics. Anthracycline therapy, in spite of its effective antitumor activity, induces systemic oxidative stress, which interferes with the effectiveness of the treatment and results in serious side effects. Fullerenols may counteract the harmful effects of anthracyclines by scavenging free radicals and thereby improve the effects of chemotherapy. Additionally, due to the hollow spherical shape, fullerenols may be used as drug carriers. Moreover, because of the existence of the currently ineffective ways for neurodegenerative diseases treatment, alternative compounds, which could prevent the negative effects of oxidative stress in the brain, are still sought. In the search of alternative methods of treatment and diagnosis, today's science is increasingly reaching for tools in the field of nanomedicine, for example, fullerenes and their water-soluble derivatives, which is addressed in the present paper.

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Fullerenol interactions with the band 3 protein and the location of fullerenol in the lipid bilayer. Fullerenol C60(OH)36, by associating with band 3 protein, does not only prevent its degradation, but can also influence the binding sites of spectrin, band 4.1 and 4.2 proteins, or actin, leading to changes in the cytoskeleton affecting erythrocyte morphology (from [13] modified).
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fig3: Fullerenol interactions with the band 3 protein and the location of fullerenol in the lipid bilayer. Fullerenol C60(OH)36, by associating with band 3 protein, does not only prevent its degradation, but can also influence the binding sites of spectrin, band 4.1 and 4.2 proteins, or actin, leading to changes in the cytoskeleton affecting erythrocyte morphology (from [13] modified).

Mentions: The many hydroxyl groups present on the surface of fullerenol enable not only attachment of various compounds (including drug molecules), but also the creation of multiple hydrogen bonds with various components of biological systems (such as protein domains of the plasma membrane or hydrophilic lipid heads) [51]. Our experiments have shown that fullerenol can be adsorbed to erythrocyte cytoskeletal proteins [13] and this interaction can be used as a drug transport mechanism (Figure 3). Prolonging the residence time of a substance (drug) in the circulation is possible by attaching it to residues in the erythrocyte membrane such as band 3 protein or glycophorin. This method has been described by Krantz [52] and is based on the use of “anchors”—molecules with functional groups with strong affinity for erythrocyte cytoskeletal proteins. As fullerenol is covered with polar OH groups, it is well suited to function as an “anchor” [13].


Fullerenols as a new therapeutic approach in nanomedicine.

Grebowski J, Kazmierska P, Krokosz A - Biomed Res Int (2013)

Fullerenol interactions with the band 3 protein and the location of fullerenol in the lipid bilayer. Fullerenol C60(OH)36, by associating with band 3 protein, does not only prevent its degradation, but can also influence the binding sites of spectrin, band 4.1 and 4.2 proteins, or actin, leading to changes in the cytoskeleton affecting erythrocyte morphology (from [13] modified).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3814052&req=5

fig3: Fullerenol interactions with the band 3 protein and the location of fullerenol in the lipid bilayer. Fullerenol C60(OH)36, by associating with band 3 protein, does not only prevent its degradation, but can also influence the binding sites of spectrin, band 4.1 and 4.2 proteins, or actin, leading to changes in the cytoskeleton affecting erythrocyte morphology (from [13] modified).
Mentions: The many hydroxyl groups present on the surface of fullerenol enable not only attachment of various compounds (including drug molecules), but also the creation of multiple hydrogen bonds with various components of biological systems (such as protein domains of the plasma membrane or hydrophilic lipid heads) [51]. Our experiments have shown that fullerenol can be adsorbed to erythrocyte cytoskeletal proteins [13] and this interaction can be used as a drug transport mechanism (Figure 3). Prolonging the residence time of a substance (drug) in the circulation is possible by attaching it to residues in the erythrocyte membrane such as band 3 protein or glycophorin. This method has been described by Krantz [52] and is based on the use of “anchors”—molecules with functional groups with strong affinity for erythrocyte cytoskeletal proteins. As fullerenol is covered with polar OH groups, it is well suited to function as an “anchor” [13].

Bottom Line: Anthracycline therapy, in spite of its effective antitumor activity, induces systemic oxidative stress, which interferes with the effectiveness of the treatment and results in serious side effects.Fullerenols may counteract the harmful effects of anthracyclines by scavenging free radicals and thereby improve the effects of chemotherapy.In the search of alternative methods of treatment and diagnosis, today's science is increasingly reaching for tools in the field of nanomedicine, for example, fullerenes and their water-soluble derivatives, which is addressed in the present paper.

View Article: PubMed Central - PubMed

Affiliation: Department of Molecular Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, ul. Pomorska 141/143, 90-236 Lodz, Poland.

ABSTRACT
Recently, much attention has been paid to the bioactive properties of water-soluble fullerene derivatives: fullerenols, with emphasis on their pro- and antioxidative properties. Due to their hydrophilic properties and the ability to scavenge free radicals, fullerenols may, in the future, provide a serious alternative to the currently used pharmacological methods in chemotherapy, treatment of neurodegenerative diseases, and radiobiology. Some of the most widely used drugs in chemotherapy are anthracycline antibiotics. Anthracycline therapy, in spite of its effective antitumor activity, induces systemic oxidative stress, which interferes with the effectiveness of the treatment and results in serious side effects. Fullerenols may counteract the harmful effects of anthracyclines by scavenging free radicals and thereby improve the effects of chemotherapy. Additionally, due to the hollow spherical shape, fullerenols may be used as drug carriers. Moreover, because of the existence of the currently ineffective ways for neurodegenerative diseases treatment, alternative compounds, which could prevent the negative effects of oxidative stress in the brain, are still sought. In the search of alternative methods of treatment and diagnosis, today's science is increasingly reaching for tools in the field of nanomedicine, for example, fullerenes and their water-soluble derivatives, which is addressed in the present paper.

Show MeSH
Related in: MedlinePlus