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Fullerenols as a new therapeutic approach in nanomedicine.

Grebowski J, Kazmierska P, Krokosz A - Biomed Res Int (2013)

Bottom Line: Anthracycline therapy, in spite of its effective antitumor activity, induces systemic oxidative stress, which interferes with the effectiveness of the treatment and results in serious side effects.Fullerenols may counteract the harmful effects of anthracyclines by scavenging free radicals and thereby improve the effects of chemotherapy.In the search of alternative methods of treatment and diagnosis, today's science is increasingly reaching for tools in the field of nanomedicine, for example, fullerenes and their water-soluble derivatives, which is addressed in the present paper.

View Article: PubMed Central - PubMed

Affiliation: Department of Molecular Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, ul. Pomorska 141/143, 90-236 Lodz, Poland.

ABSTRACT
Recently, much attention has been paid to the bioactive properties of water-soluble fullerene derivatives: fullerenols, with emphasis on their pro- and antioxidative properties. Due to their hydrophilic properties and the ability to scavenge free radicals, fullerenols may, in the future, provide a serious alternative to the currently used pharmacological methods in chemotherapy, treatment of neurodegenerative diseases, and radiobiology. Some of the most widely used drugs in chemotherapy are anthracycline antibiotics. Anthracycline therapy, in spite of its effective antitumor activity, induces systemic oxidative stress, which interferes with the effectiveness of the treatment and results in serious side effects. Fullerenols may counteract the harmful effects of anthracyclines by scavenging free radicals and thereby improve the effects of chemotherapy. Additionally, due to the hollow spherical shape, fullerenols may be used as drug carriers. Moreover, because of the existence of the currently ineffective ways for neurodegenerative diseases treatment, alternative compounds, which could prevent the negative effects of oxidative stress in the brain, are still sought. In the search of alternative methods of treatment and diagnosis, today's science is increasingly reaching for tools in the field of nanomedicine, for example, fullerenes and their water-soluble derivatives, which is addressed in the present paper.

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The structure of fullerenol.
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fig1: The structure of fullerenol.

Mentions: In recent years, much attention has been paid to research on the bioactive characteristics of newly discovered water-soluble fullerene derivatives. Greater emphasis has been placed on their pro- and antioxidant properties [1–4] which result from the presence of delocalized double π bonds in the fullerene cage. The poor solubility of fullerenes in polar liquids has been a major hindrance in terms of their potential biomedical applications. Therefore, the possibility of attaching polar functional groups to the carbon fullerene cage, in an effort to increase their solubility in polar solvents (especially in water), was explored. Fullerene derivatives with hydrophilic properties were obtained by adding hydroxyl groups to C60, resulting in a polyhydroxylated C60 fullerene (fullerenol; fullerol, C60(OH)n) [5–8]. The general structure of fullerenol is shown in Figure 1. The fullerenol molecule can be excited and transformed into the triplet state with visible or ultraviolet light creating a reactive molecule that easily interacts with oxygen or biomolecules and has applications in photosensitization [2, 9].


Fullerenols as a new therapeutic approach in nanomedicine.

Grebowski J, Kazmierska P, Krokosz A - Biomed Res Int (2013)

The structure of fullerenol.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3814052&req=5

fig1: The structure of fullerenol.
Mentions: In recent years, much attention has been paid to research on the bioactive characteristics of newly discovered water-soluble fullerene derivatives. Greater emphasis has been placed on their pro- and antioxidant properties [1–4] which result from the presence of delocalized double π bonds in the fullerene cage. The poor solubility of fullerenes in polar liquids has been a major hindrance in terms of their potential biomedical applications. Therefore, the possibility of attaching polar functional groups to the carbon fullerene cage, in an effort to increase their solubility in polar solvents (especially in water), was explored. Fullerene derivatives with hydrophilic properties were obtained by adding hydroxyl groups to C60, resulting in a polyhydroxylated C60 fullerene (fullerenol; fullerol, C60(OH)n) [5–8]. The general structure of fullerenol is shown in Figure 1. The fullerenol molecule can be excited and transformed into the triplet state with visible or ultraviolet light creating a reactive molecule that easily interacts with oxygen or biomolecules and has applications in photosensitization [2, 9].

Bottom Line: Anthracycline therapy, in spite of its effective antitumor activity, induces systemic oxidative stress, which interferes with the effectiveness of the treatment and results in serious side effects.Fullerenols may counteract the harmful effects of anthracyclines by scavenging free radicals and thereby improve the effects of chemotherapy.In the search of alternative methods of treatment and diagnosis, today's science is increasingly reaching for tools in the field of nanomedicine, for example, fullerenes and their water-soluble derivatives, which is addressed in the present paper.

View Article: PubMed Central - PubMed

Affiliation: Department of Molecular Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, ul. Pomorska 141/143, 90-236 Lodz, Poland.

ABSTRACT
Recently, much attention has been paid to the bioactive properties of water-soluble fullerene derivatives: fullerenols, with emphasis on their pro- and antioxidative properties. Due to their hydrophilic properties and the ability to scavenge free radicals, fullerenols may, in the future, provide a serious alternative to the currently used pharmacological methods in chemotherapy, treatment of neurodegenerative diseases, and radiobiology. Some of the most widely used drugs in chemotherapy are anthracycline antibiotics. Anthracycline therapy, in spite of its effective antitumor activity, induces systemic oxidative stress, which interferes with the effectiveness of the treatment and results in serious side effects. Fullerenols may counteract the harmful effects of anthracyclines by scavenging free radicals and thereby improve the effects of chemotherapy. Additionally, due to the hollow spherical shape, fullerenols may be used as drug carriers. Moreover, because of the existence of the currently ineffective ways for neurodegenerative diseases treatment, alternative compounds, which could prevent the negative effects of oxidative stress in the brain, are still sought. In the search of alternative methods of treatment and diagnosis, today's science is increasingly reaching for tools in the field of nanomedicine, for example, fullerenes and their water-soluble derivatives, which is addressed in the present paper.

Show MeSH
Related in: MedlinePlus