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Epicardial coronary arteries in khat chewers presenting with myocardial infarction.

Al-Motarreb A, Shabana A, El-Menyar A - Int J Vasc Med (2013)

Bottom Line: Group 3 patients were more likely to have multivessel disease, severe left anterior descending (LAD), right coronary artery (RCA) stenosis and total RCA, and left circumflex (Lcx) occlusion compared to other groups.In multivariate analysis, age, diabetes mellitus, and smoking were significant independent predictors for significant coronary artery lesions; however, khat chewing did not show such association.Conclusions.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Faculty of Medicine, Sana'a University, Sana'a 13078, Yemen.

ABSTRACT
Background. Khat chewing is a common habit in Yemen despite increased evidence of its negative impact on the cardiovascular system. Aims. We aimed to study the epicardial coronary arteries in khat chewers presenting with myocardial infarction (AMI). Materials and Methods. A descriptive, cross-sectional study was conducted between November 2008 and May 2009 in Yemen. AMI patients who underwent coronary angiogram were enrolled and divided into groups (gp): gp1 (diabetic and khat chewers), gp2 (khat chewers and nondiabetic), and gp3 (diabetic and non-khat users). Results. Of 347 AMI patients 63%, 21%, and 16% were in gp 2, 3, and 1, respectively. Khat chewers were younger in comparison to non-khat users. Group 3 patients were more likely to have multivessel disease, severe left anterior descending (LAD), right coronary artery (RCA) stenosis and total RCA, and left circumflex (Lcx) occlusion compared to other groups. Group 1 patients were more likely to have total LAD occlusion and severe Lcx lesions. In multivariate analysis, age, diabetes mellitus, and smoking were significant independent predictors for significant coronary artery lesions; however, khat chewing did not show such association. Conclusions. Coronary spasm is the main mechanism of AMI in khat chewers. The impact of our finding for risk stratification and management warrants further studies.

No MeSH data available.


Related in: MedlinePlus

The vascular effect of cathinone in pigs; a courtesy from Dr. Ahmed Al-Motarreb.
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fig2: The vascular effect of cathinone in pigs; a courtesy from Dr. Ahmed Al-Motarreb.

Mentions: Our previous data support the postulated mechanisms by which khat can induce AMI; Al-Motarreb and Broadley [22] reported that cathinone infusion induced marked vasoconstriction of the coronary vasculature in isolated guinea pig hearts (Figure 2). In another study, such vasoconstriction effect was not blocked by the alpha1-adrenoceptor antagonist prazocin or by the neuronal uptake inhibitor cocaine [23].


Epicardial coronary arteries in khat chewers presenting with myocardial infarction.

Al-Motarreb A, Shabana A, El-Menyar A - Int J Vasc Med (2013)

The vascular effect of cathinone in pigs; a courtesy from Dr. Ahmed Al-Motarreb.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3814045&req=5

fig2: The vascular effect of cathinone in pigs; a courtesy from Dr. Ahmed Al-Motarreb.
Mentions: Our previous data support the postulated mechanisms by which khat can induce AMI; Al-Motarreb and Broadley [22] reported that cathinone infusion induced marked vasoconstriction of the coronary vasculature in isolated guinea pig hearts (Figure 2). In another study, such vasoconstriction effect was not blocked by the alpha1-adrenoceptor antagonist prazocin or by the neuronal uptake inhibitor cocaine [23].

Bottom Line: Group 3 patients were more likely to have multivessel disease, severe left anterior descending (LAD), right coronary artery (RCA) stenosis and total RCA, and left circumflex (Lcx) occlusion compared to other groups.In multivariate analysis, age, diabetes mellitus, and smoking were significant independent predictors for significant coronary artery lesions; however, khat chewing did not show such association.Conclusions.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Faculty of Medicine, Sana'a University, Sana'a 13078, Yemen.

ABSTRACT
Background. Khat chewing is a common habit in Yemen despite increased evidence of its negative impact on the cardiovascular system. Aims. We aimed to study the epicardial coronary arteries in khat chewers presenting with myocardial infarction (AMI). Materials and Methods. A descriptive, cross-sectional study was conducted between November 2008 and May 2009 in Yemen. AMI patients who underwent coronary angiogram were enrolled and divided into groups (gp): gp1 (diabetic and khat chewers), gp2 (khat chewers and nondiabetic), and gp3 (diabetic and non-khat users). Results. Of 347 AMI patients 63%, 21%, and 16% were in gp 2, 3, and 1, respectively. Khat chewers were younger in comparison to non-khat users. Group 3 patients were more likely to have multivessel disease, severe left anterior descending (LAD), right coronary artery (RCA) stenosis and total RCA, and left circumflex (Lcx) occlusion compared to other groups. Group 1 patients were more likely to have total LAD occlusion and severe Lcx lesions. In multivariate analysis, age, diabetes mellitus, and smoking were significant independent predictors for significant coronary artery lesions; however, khat chewing did not show such association. Conclusions. Coronary spasm is the main mechanism of AMI in khat chewers. The impact of our finding for risk stratification and management warrants further studies.

No MeSH data available.


Related in: MedlinePlus