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An extremely rare, remote intracerebral metastasis of oral cavity cancer: a case report.

Leimert M, Juratli TA, Lindner C, Geiger KD, Gerber J, Schackert G, Kirsch M - Case Rep Med (2013)

Bottom Line: MR imaging revealed an enhancing lesion in the right parietal lobe.The patient refused whole brain radiation therapy and died from pulmonary metastatic disease 10 months after the neurosurgical intervention without any cerebral recurrence.To the authors' knowledge, only two similar cases have been previously reported.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurosurgery, University Hospital Carl Gustav Carus, Technical University of Dresden, Fetscherstraße 74, 01307 Dresden, Germany.

ABSTRACT
Distant brain metastases from oral squamous cell carcinomas (OSCC) are extremely rare. Here we describe a case of a 53-year-old man with a primary OSCC who referred to the neurosurgical department because of epileptic seizures. MR imaging revealed an enhancing lesion in the right parietal lobe. A craniotomy with tumor removing was performed. Histopathological examination verified an invasive, minimally differentiated metastasis of the primary OSCC. The patient refused whole brain radiation therapy and died from pulmonary metastatic disease 10 months after the neurosurgical intervention without any cerebral recurrence. To the authors' knowledge, only two similar cases have been previously reported.

No MeSH data available.


Related in: MedlinePlus

Histological diagnosis of the cerebral metastasis revealed a minimally differentiated squamous cell carcinoma with single horn pearls, solid growth, pleomorphic nuclei, and numerous mitosis, adjacent to edematous brain tissue with extensive reactive gliosis. H and E stain.
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fig2: Histological diagnosis of the cerebral metastasis revealed a minimally differentiated squamous cell carcinoma with single horn pearls, solid growth, pleomorphic nuclei, and numerous mitosis, adjacent to edematous brain tissue with extensive reactive gliosis. H and E stain.

Mentions: MR imaging revealed a heterogeneously enhancing lesion of approximately 2 × 1 cm in the right parietal lobe, typically located in the cortical/subcortical area (Figure 1). The patient was now assessed as T3N3M1, and surgical resection of the suspected brain metastasis was advised. Preoperative computed tomography (CT) of the chest showed progress of the pulmonary metastases. A craniotomy was performed, and the tumor was completely removed judged upon intraoperative microscopic and postoperative MR imaging. Histopathological examination verified an invasive, minimally differentiated metastasis of the primary OSCC (Figures 2 and 3(b)–3(d)). The patient refused whole brain radiation therapy (30 Gy) and died from pulmonary metastatic disease 10 months after the neurosurgical intervention without any cerebral recurrence.


An extremely rare, remote intracerebral metastasis of oral cavity cancer: a case report.

Leimert M, Juratli TA, Lindner C, Geiger KD, Gerber J, Schackert G, Kirsch M - Case Rep Med (2013)

Histological diagnosis of the cerebral metastasis revealed a minimally differentiated squamous cell carcinoma with single horn pearls, solid growth, pleomorphic nuclei, and numerous mitosis, adjacent to edematous brain tissue with extensive reactive gliosis. H and E stain.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3814042&req=5

fig2: Histological diagnosis of the cerebral metastasis revealed a minimally differentiated squamous cell carcinoma with single horn pearls, solid growth, pleomorphic nuclei, and numerous mitosis, adjacent to edematous brain tissue with extensive reactive gliosis. H and E stain.
Mentions: MR imaging revealed a heterogeneously enhancing lesion of approximately 2 × 1 cm in the right parietal lobe, typically located in the cortical/subcortical area (Figure 1). The patient was now assessed as T3N3M1, and surgical resection of the suspected brain metastasis was advised. Preoperative computed tomography (CT) of the chest showed progress of the pulmonary metastases. A craniotomy was performed, and the tumor was completely removed judged upon intraoperative microscopic and postoperative MR imaging. Histopathological examination verified an invasive, minimally differentiated metastasis of the primary OSCC (Figures 2 and 3(b)–3(d)). The patient refused whole brain radiation therapy (30 Gy) and died from pulmonary metastatic disease 10 months after the neurosurgical intervention without any cerebral recurrence.

Bottom Line: MR imaging revealed an enhancing lesion in the right parietal lobe.The patient refused whole brain radiation therapy and died from pulmonary metastatic disease 10 months after the neurosurgical intervention without any cerebral recurrence.To the authors' knowledge, only two similar cases have been previously reported.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurosurgery, University Hospital Carl Gustav Carus, Technical University of Dresden, Fetscherstraße 74, 01307 Dresden, Germany.

ABSTRACT
Distant brain metastases from oral squamous cell carcinomas (OSCC) are extremely rare. Here we describe a case of a 53-year-old man with a primary OSCC who referred to the neurosurgical department because of epileptic seizures. MR imaging revealed an enhancing lesion in the right parietal lobe. A craniotomy with tumor removing was performed. Histopathological examination verified an invasive, minimally differentiated metastasis of the primary OSCC. The patient refused whole brain radiation therapy and died from pulmonary metastatic disease 10 months after the neurosurgical intervention without any cerebral recurrence. To the authors' knowledge, only two similar cases have been previously reported.

No MeSH data available.


Related in: MedlinePlus