Limits...
Toward a molecular classification of colorectal cancer: the role of microsatellite instability status.

Heinimann K - Front Oncol (2013)

Bottom Line: Microsatellite instability (MSI) is the molecular hallmark of DNA mismatch repair deficiency.Since its initial description in colorectal cancer (CRC) in 1993 and its association with Lynch syndrome, the most common inherited cancer predisposition world-wide, accumulating evidence suggests that MSI status may also be of concrete prognostic and predictive value in the management of sporadic CRC.This mini review aims at providing a concise survey of the molecular basis and the multifaceted role(s) of MSI status in today's clinical practice.

View Article: PubMed Central - PubMed

Affiliation: Department of Biomedicine, Research Group Human Genomics , Basel , Switzerland ; Medical Genetics, University Hospital Basel , Basel , Switzerland.

ABSTRACT
Microsatellite instability (MSI) is the molecular hallmark of DNA mismatch repair deficiency. Since its initial description in colorectal cancer (CRC) in 1993 and its association with Lynch syndrome, the most common inherited cancer predisposition world-wide, accumulating evidence suggests that MSI status may also be of concrete prognostic and predictive value in the management of sporadic CRC. This mini review aims at providing a concise survey of the molecular basis and the multifaceted role(s) of MSI status in today's clinical practice.

No MeSH data available.


Related in: MedlinePlus

The role of microsatellite instability (MSI) status in clinical management of colorectal cancer patients. 5-FU denotes 5-fluoro-uracil.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3814007&req=5

Figure 1: The role of microsatellite instability (MSI) status in clinical management of colorectal cancer patients. 5-FU denotes 5-fluoro-uracil.

Mentions: Since their initial description it became evident that the 15% of sporadic MSI-H CRCs exhibit a distinct clinico-pathological profile, which they largely share with LS-related CRC and which distinguishes them from their MSS counterparts (Figure 1). Already in the seminal work by Thibodeau et al. (2) MSI-H CRC were predominantly located in the proximal colon and associated with increased patient survival and prognosis (2). Most of them were later found to exhibit loss of MLH1 protein expression which could be attributed to epigenetic silencing of the respective promoter, later also referred to as “CpG island methylator phenotype” since it often occurs in the context of global hypermethylation (16, 17). Regarding their molecular-histopathological profile MSI-H CRC display a diploid state, tend to be poorly differentiated, mucinous, and show prominent lymphocytic infiltration (15).


Toward a molecular classification of colorectal cancer: the role of microsatellite instability status.

Heinimann K - Front Oncol (2013)

The role of microsatellite instability (MSI) status in clinical management of colorectal cancer patients. 5-FU denotes 5-fluoro-uracil.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3814007&req=5

Figure 1: The role of microsatellite instability (MSI) status in clinical management of colorectal cancer patients. 5-FU denotes 5-fluoro-uracil.
Mentions: Since their initial description it became evident that the 15% of sporadic MSI-H CRCs exhibit a distinct clinico-pathological profile, which they largely share with LS-related CRC and which distinguishes them from their MSS counterparts (Figure 1). Already in the seminal work by Thibodeau et al. (2) MSI-H CRC were predominantly located in the proximal colon and associated with increased patient survival and prognosis (2). Most of them were later found to exhibit loss of MLH1 protein expression which could be attributed to epigenetic silencing of the respective promoter, later also referred to as “CpG island methylator phenotype” since it often occurs in the context of global hypermethylation (16, 17). Regarding their molecular-histopathological profile MSI-H CRC display a diploid state, tend to be poorly differentiated, mucinous, and show prominent lymphocytic infiltration (15).

Bottom Line: Microsatellite instability (MSI) is the molecular hallmark of DNA mismatch repair deficiency.Since its initial description in colorectal cancer (CRC) in 1993 and its association with Lynch syndrome, the most common inherited cancer predisposition world-wide, accumulating evidence suggests that MSI status may also be of concrete prognostic and predictive value in the management of sporadic CRC.This mini review aims at providing a concise survey of the molecular basis and the multifaceted role(s) of MSI status in today's clinical practice.

View Article: PubMed Central - PubMed

Affiliation: Department of Biomedicine, Research Group Human Genomics , Basel , Switzerland ; Medical Genetics, University Hospital Basel , Basel , Switzerland.

ABSTRACT
Microsatellite instability (MSI) is the molecular hallmark of DNA mismatch repair deficiency. Since its initial description in colorectal cancer (CRC) in 1993 and its association with Lynch syndrome, the most common inherited cancer predisposition world-wide, accumulating evidence suggests that MSI status may also be of concrete prognostic and predictive value in the management of sporadic CRC. This mini review aims at providing a concise survey of the molecular basis and the multifaceted role(s) of MSI status in today's clinical practice.

No MeSH data available.


Related in: MedlinePlus