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Computer-controlled stimulation for functional magnetic resonance imaging studies of the neonatal olfactory system.

Arichi T, Gordon-Williams R, Allievi A, Groves AM, Burdet E, Edwards AD - Acta Paediatr. (2013)

Bottom Line: The system was used to present the odour of infant formula milk in a validation group of seven neonatal subjects at term equivalent postmenstrual age (median age 40 weeks).A safe, reliable and reproducible pattern of stimulation was delivered leading to well-localized positive BOLD functional responses in the piriform cortex, amygdala, thalamus, insular cortex and cerebellum.The described system is therefore suitable for detailed studies of the ontology of olfactory sensation and perception during early human brain development.

View Article: PubMed Central - PubMed

Affiliation: Centre for the Developing Brain, Division of Imaging Sciences & Biomedical Engineering, Kings College London, St. Thomas' Hospital, London, UK.

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The average response to the odour of formula milk in seven infants at term equivalent postmenstrual age. The results of a one-sample nonparametric t-test (with a false discovery rate correction for multiple comparisons at threshold p < 0.05) have been overlaid on a custom T2-weighted template image in the coronal (A,B) and axial (C,D) planes. Clusters of activation are seen in the right piriform cortex and amygdala (blue arrows), the right thalamus (orange arrow), the left insular area (white arrow) and cerebellum (green arrow).
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fig04: The average response to the odour of formula milk in seven infants at term equivalent postmenstrual age. The results of a one-sample nonparametric t-test (with a false discovery rate correction for multiple comparisons at threshold p < 0.05) have been overlaid on a custom T2-weighted template image in the coronal (A,B) and axial (C,D) planes. Clusters of activation are seen in the right piriform cortex and amygdala (blue arrows), the right thalamus (orange arrow), the left insular area (white arrow) and cerebellum (green arrow).

Mentions: The group analysis identified a widely dispersed but discrete pattern of activation, similar to that described in olfactory fMRI studies in adult subjects (14). Well-localized clusters of activation were seen in the right piriform cortex, the right thalamus, the left insular area and cerebellum (see Fig. 4). The activity in the orbito-frontal regions seen on the lower-level analyses in a subgroup of subjects did not reach significance in the group analysis.


Computer-controlled stimulation for functional magnetic resonance imaging studies of the neonatal olfactory system.

Arichi T, Gordon-Williams R, Allievi A, Groves AM, Burdet E, Edwards AD - Acta Paediatr. (2013)

The average response to the odour of formula milk in seven infants at term equivalent postmenstrual age. The results of a one-sample nonparametric t-test (with a false discovery rate correction for multiple comparisons at threshold p < 0.05) have been overlaid on a custom T2-weighted template image in the coronal (A,B) and axial (C,D) planes. Clusters of activation are seen in the right piriform cortex and amygdala (blue arrows), the right thalamus (orange arrow), the left insular area (white arrow) and cerebellum (green arrow).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3795441&req=5

fig04: The average response to the odour of formula milk in seven infants at term equivalent postmenstrual age. The results of a one-sample nonparametric t-test (with a false discovery rate correction for multiple comparisons at threshold p < 0.05) have been overlaid on a custom T2-weighted template image in the coronal (A,B) and axial (C,D) planes. Clusters of activation are seen in the right piriform cortex and amygdala (blue arrows), the right thalamus (orange arrow), the left insular area (white arrow) and cerebellum (green arrow).
Mentions: The group analysis identified a widely dispersed but discrete pattern of activation, similar to that described in olfactory fMRI studies in adult subjects (14). Well-localized clusters of activation were seen in the right piriform cortex, the right thalamus, the left insular area and cerebellum (see Fig. 4). The activity in the orbito-frontal regions seen on the lower-level analyses in a subgroup of subjects did not reach significance in the group analysis.

Bottom Line: The system was used to present the odour of infant formula milk in a validation group of seven neonatal subjects at term equivalent postmenstrual age (median age 40 weeks).A safe, reliable and reproducible pattern of stimulation was delivered leading to well-localized positive BOLD functional responses in the piriform cortex, amygdala, thalamus, insular cortex and cerebellum.The described system is therefore suitable for detailed studies of the ontology of olfactory sensation and perception during early human brain development.

View Article: PubMed Central - PubMed

Affiliation: Centre for the Developing Brain, Division of Imaging Sciences & Biomedical Engineering, Kings College London, St. Thomas' Hospital, London, UK.

Show MeSH