Computer-controlled stimulation for functional magnetic resonance imaging studies of the neonatal olfactory system.
Bottom Line: The system was used to present the odour of infant formula milk in a validation group of seven neonatal subjects at term equivalent postmenstrual age (median age 40 weeks).A safe, reliable and reproducible pattern of stimulation was delivered leading to well-localized positive BOLD functional responses in the piriform cortex, amygdala, thalamus, insular cortex and cerebellum.The described system is therefore suitable for detailed studies of the ontology of olfactory sensation and perception during early human brain development.
Affiliation: Centre for the Developing Brain, Division of Imaging Sciences & Biomedical Engineering, Kings College London, St. Thomas' Hospital, London, UK.Show MeSH
Mentions: The group analysis identified a widely dispersed but discrete pattern of activation, similar to that described in olfactory fMRI studies in adult subjects (14). Well-localized clusters of activation were seen in the right piriform cortex, the right thalamus, the left insular area and cerebellum (see Fig. 4). The activity in the orbito-frontal regions seen on the lower-level analyses in a subgroup of subjects did not reach significance in the group analysis.
Affiliation: Centre for the Developing Brain, Division of Imaging Sciences & Biomedical Engineering, Kings College London, St. Thomas' Hospital, London, UK.