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Head and neck sarcomas: a comprehensive cancer center experience.

Tejani MA, Galloway TJ, Lango M, Ridge JA, von Mehren M - Cancers (Basel) (2013)

Bottom Line: The type of primary therapy and disease outcomes were analyzed.Cox proportional hazards regression analysis was performed to identify predictors of disease-free survival (DFS) and overall survival (OS).The HR and 95% CI for Cox model and median DFS/OS analyzed by Kaplan-Meier curves were calculated.

View Article: PubMed Central - PubMed

Affiliation: Division of Hematology/Oncology, University of Rochester Medical Center, Rochester, NY 14642, USA. margaret.vonmehren@fccc.edu.

ABSTRACT
Head/neck sarcomas are rare, accounting for about 1% of head/neck malignancies and 5% of sarcomas. Outcomes have historically been worse in this group, due to anatomic constraints leading to difficulty in completely excising tumors, with high rates of local recurrence. We retrospectively analyzed cases of head/neck soft tissue sarcomas (STS) and osteogenic sarcomas managed in a multi-disciplinary setting at Fox Chase Cancer Center from 1999-2009 to describe clinicopathologic characteristics, treatment, outcomes, and prognostic factors for disease control and survival. Thirty patients with STS and seven patients with osteogenic sarcoma were identified. Most STS were high grade (23) and almost all were localized at presentation (28). Common histologies were synovial cell (6), rhabdomyosarcoma (5), angiosarcoma (4), liposarcoma (4) and leiomyosarcoma (3). The type of primary therapy and disease outcomes were analyzed. Cox proportional hazards regression analysis was performed to identify predictors of disease-free survival (DFS) and overall survival (OS). The HR and 95% CI for Cox model and median DFS/OS analyzed by Kaplan-Meier curves were calculated.

No MeSH data available.


Related in: MedlinePlus

(a) DFS and OS according to margin status. (b) DFS and OS according to size in Soft Tissue Sarcoma Cases.
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cancers-05-00890-f001: (a) DFS and OS according to margin status. (b) DFS and OS according to size in Soft Tissue Sarcoma Cases.

Mentions: Univariate analysis using Cox progression hazard model was performed using margin status, size (<5 cm vs. >5 cm), age at diagnosis (<50 vs. >50), grade (low-intermediate vs. high) and multiple other recognized prognostic factors to identify predictors of DFS and OS. Patients with R1 resections had worse DFS (HR 3.74, 95% CI: 0.98–14.34) and OS (HR 4.4, 95% CI: 1.11–17.4). Tumors >5 cm were also associated with worse DFS (HR 2.79, 95% CI: 0.84–9.25). Age and grade did not correlate with outcome in our cohort. (See Table 3 and Figure 1).


Head and neck sarcomas: a comprehensive cancer center experience.

Tejani MA, Galloway TJ, Lango M, Ridge JA, von Mehren M - Cancers (Basel) (2013)

(a) DFS and OS according to margin status. (b) DFS and OS according to size in Soft Tissue Sarcoma Cases.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3795370&req=5

cancers-05-00890-f001: (a) DFS and OS according to margin status. (b) DFS and OS according to size in Soft Tissue Sarcoma Cases.
Mentions: Univariate analysis using Cox progression hazard model was performed using margin status, size (<5 cm vs. >5 cm), age at diagnosis (<50 vs. >50), grade (low-intermediate vs. high) and multiple other recognized prognostic factors to identify predictors of DFS and OS. Patients with R1 resections had worse DFS (HR 3.74, 95% CI: 0.98–14.34) and OS (HR 4.4, 95% CI: 1.11–17.4). Tumors >5 cm were also associated with worse DFS (HR 2.79, 95% CI: 0.84–9.25). Age and grade did not correlate with outcome in our cohort. (See Table 3 and Figure 1).

Bottom Line: The type of primary therapy and disease outcomes were analyzed.Cox proportional hazards regression analysis was performed to identify predictors of disease-free survival (DFS) and overall survival (OS).The HR and 95% CI for Cox model and median DFS/OS analyzed by Kaplan-Meier curves were calculated.

View Article: PubMed Central - PubMed

Affiliation: Division of Hematology/Oncology, University of Rochester Medical Center, Rochester, NY 14642, USA. margaret.vonmehren@fccc.edu.

ABSTRACT
Head/neck sarcomas are rare, accounting for about 1% of head/neck malignancies and 5% of sarcomas. Outcomes have historically been worse in this group, due to anatomic constraints leading to difficulty in completely excising tumors, with high rates of local recurrence. We retrospectively analyzed cases of head/neck soft tissue sarcomas (STS) and osteogenic sarcomas managed in a multi-disciplinary setting at Fox Chase Cancer Center from 1999-2009 to describe clinicopathologic characteristics, treatment, outcomes, and prognostic factors for disease control and survival. Thirty patients with STS and seven patients with osteogenic sarcoma were identified. Most STS were high grade (23) and almost all were localized at presentation (28). Common histologies were synovial cell (6), rhabdomyosarcoma (5), angiosarcoma (4), liposarcoma (4) and leiomyosarcoma (3). The type of primary therapy and disease outcomes were analyzed. Cox proportional hazards regression analysis was performed to identify predictors of disease-free survival (DFS) and overall survival (OS). The HR and 95% CI for Cox model and median DFS/OS analyzed by Kaplan-Meier curves were calculated.

No MeSH data available.


Related in: MedlinePlus