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Correlation of serum neutrophil gelatinase-associated lipocalin with acute kidney injury in hypertensive disorders of pregnancy.

Patel M, Sachan R, Gangwar R, Sachan P, Natu S - Int J Nephrol Renovasc Dis (2013)

Bottom Line: Serum NGAL had a positive association with increasing proteinuria.It also had a positive correlation with systolic blood pressure (r∼0.36), diastolic blood pressure (r∼0.37), and serum creatinine (r∼0.4).NGAL was found to be significantly correlated with creatinine in the cases with the value of the correlation coefficient being 0.4.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine, King George's Medical University, Lucknow, Uttar Pradesh, India.

ABSTRACT
Hypertensive disorders of pregnancy (HDP) remain one of the largest single causes of maternal and fetal morbidity and mortality, accounting for 16.1% of maternal deaths in developed countries. The aim of the study was to evaluate acute kidney injury (AKI) in hypertensive disorders of pregnancy and to examine the correlation of serum neutrophil gelatinase-associated lipocalin (NGAL) with acute kidney injury. This prospective case control study was carried out over a period of 1 year. After written, informed consent and ethical clearance, 149 cases of hypertensive disorders of pregnancy were screened, and seven were lost to follow-up. Acute kidney injury was detected in 88 cases and acute renal failure in 30 cases of HDP. Thirty-one healthy pregnant nonhypertensive women were enrolled as controls. Quantitative measurement of serum NGAL levels was done by enzyme linked immunosorbent assay technique using a sandwich enzyme-linked immunosorbent assay kit. As per the Kidney Diseases Improving Global Outcomes International guidelines acute kidney injury network (AKIN), 50 cases (42.37%) of AKI stage I, 38 (32.2%) cases of AKI stage II, and 30 (25.42%) cases of renal failure were detected. Serum NGAL had a positive association with increasing proteinuria. It also had a positive correlation with systolic blood pressure (r∼0.36), diastolic blood pressure (r∼0.37), and serum creatinine (r∼0.4). NGAL was found to be significantly correlated with creatinine in the cases with the value of the correlation coefficient being 0.4. This direct correlation might be a consequence of endothelial dysfunction on which hypertension and proteinuria probably depends.

No MeSH data available.


Related in: MedlinePlus

Scatter plot of serum creatinine versus neutrophil gelatinase-associated lipocalin (control).Notes: There is a negative correlation between values of neutrophil gelatinase-associated lipocalin and serum creatinine. Increases in the values of NGAL result in decreases in the values of serum creatinine.Abbreviation: NGAL, neutrophil gelatinase-associated lipocalin.
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f4-ijnrd-6-181: Scatter plot of serum creatinine versus neutrophil gelatinase-associated lipocalin (control).Notes: There is a negative correlation between values of neutrophil gelatinase-associated lipocalin and serum creatinine. Increases in the values of NGAL result in decreases in the values of serum creatinine.Abbreviation: NGAL, neutrophil gelatinase-associated lipocalin.

Mentions: Within the cases (pooled data), there was a significant positive correlation between the values of serum NGAL and serum creatinine (y = 1.56 + 0.00007*x, r = 0.4) (P < 0.01) (Figure 3). In the control group, there was a negative correlation between serum NGAL and serum creatinine (y = 0.6–0.00003x, r = 0.06) (Figures 3 and 4).


Correlation of serum neutrophil gelatinase-associated lipocalin with acute kidney injury in hypertensive disorders of pregnancy.

Patel M, Sachan R, Gangwar R, Sachan P, Natu S - Int J Nephrol Renovasc Dis (2013)

Scatter plot of serum creatinine versus neutrophil gelatinase-associated lipocalin (control).Notes: There is a negative correlation between values of neutrophil gelatinase-associated lipocalin and serum creatinine. Increases in the values of NGAL result in decreases in the values of serum creatinine.Abbreviation: NGAL, neutrophil gelatinase-associated lipocalin.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3794962&req=5

f4-ijnrd-6-181: Scatter plot of serum creatinine versus neutrophil gelatinase-associated lipocalin (control).Notes: There is a negative correlation between values of neutrophil gelatinase-associated lipocalin and serum creatinine. Increases in the values of NGAL result in decreases in the values of serum creatinine.Abbreviation: NGAL, neutrophil gelatinase-associated lipocalin.
Mentions: Within the cases (pooled data), there was a significant positive correlation between the values of serum NGAL and serum creatinine (y = 1.56 + 0.00007*x, r = 0.4) (P < 0.01) (Figure 3). In the control group, there was a negative correlation between serum NGAL and serum creatinine (y = 0.6–0.00003x, r = 0.06) (Figures 3 and 4).

Bottom Line: Serum NGAL had a positive association with increasing proteinuria.It also had a positive correlation with systolic blood pressure (r∼0.36), diastolic blood pressure (r∼0.37), and serum creatinine (r∼0.4).NGAL was found to be significantly correlated with creatinine in the cases with the value of the correlation coefficient being 0.4.

View Article: PubMed Central - PubMed

Affiliation: Department of Medicine, King George's Medical University, Lucknow, Uttar Pradesh, India.

ABSTRACT
Hypertensive disorders of pregnancy (HDP) remain one of the largest single causes of maternal and fetal morbidity and mortality, accounting for 16.1% of maternal deaths in developed countries. The aim of the study was to evaluate acute kidney injury (AKI) in hypertensive disorders of pregnancy and to examine the correlation of serum neutrophil gelatinase-associated lipocalin (NGAL) with acute kidney injury. This prospective case control study was carried out over a period of 1 year. After written, informed consent and ethical clearance, 149 cases of hypertensive disorders of pregnancy were screened, and seven were lost to follow-up. Acute kidney injury was detected in 88 cases and acute renal failure in 30 cases of HDP. Thirty-one healthy pregnant nonhypertensive women were enrolled as controls. Quantitative measurement of serum NGAL levels was done by enzyme linked immunosorbent assay technique using a sandwich enzyme-linked immunosorbent assay kit. As per the Kidney Diseases Improving Global Outcomes International guidelines acute kidney injury network (AKIN), 50 cases (42.37%) of AKI stage I, 38 (32.2%) cases of AKI stage II, and 30 (25.42%) cases of renal failure were detected. Serum NGAL had a positive association with increasing proteinuria. It also had a positive correlation with systolic blood pressure (r∼0.36), diastolic blood pressure (r∼0.37), and serum creatinine (r∼0.4). NGAL was found to be significantly correlated with creatinine in the cases with the value of the correlation coefficient being 0.4. This direct correlation might be a consequence of endothelial dysfunction on which hypertension and proteinuria probably depends.

No MeSH data available.


Related in: MedlinePlus