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Magnetic nanosystem for cancer therapy using oncocalyxone a, an antitomour secondary metabolite isolated from a Brazilian plant.

Barreto AC, Santiago VR, Freire RM, Mazzetto SE, Denardin JC, Mele G, Cavalcante IM, Ribeiro ME, Ricardo NM, Gonçalves T, Carbone L, Lemos TL, Pessoa OD, Fechine PB - Int J Mol Sci (2013)

Bottom Line: Onco A was associated with magnetite nanoparticles in order to obtain magnetic properties.The MO-20 presented a size of about 30 nm and globular morphology.In addition, drug releasing experiments were performed, where it was observed the presence of the anomalous transport.

View Article: PubMed Central - PubMed

Affiliation: Advanced Materials Chemistry Group (GQMAT), Analytical and Physical-Chemistry Department, Federal University of Ceará (UFC), Campus do Pici 12100, CEP 60451-970 Fortaleza-CE, Brazil. fechine@ufc.br.

ABSTRACT
This paper describes the investigation and development of a novel magnetic drug delivery nanosystem (labeled as MO-20) for cancer therapy. The drug employed was oncocalyxone A (onco A), which was isolated from Auxemma oncocalyx, an endemic Brazilian plant. It has a series of pharmacological properties: antioxidant, cytotoxic, analgesic, anti-inflammatory, antitumor and antiplatelet. Onco A was associated with magnetite nanoparticles in order to obtain magnetic properties. The components of MO-20 were characterized by XRD, FTIR, TGA, TEM and Magnetization curves. The MO-20 presented a size of about 30 nm and globular morphology. In addition, drug releasing experiments were performed, where it was observed the presence of the anomalous transport. The results found in this work showed the potential of onco A for future applications of the MO-20 as a new magnetic drug release nanosystem for cancer treatment.

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Magnetization curves of (a) Fe3O4 and (b) MO-20. The solid lines correspond to the fitting with the Langevin equation (see text).
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f4-ijms-14-18269: Magnetization curves of (a) Fe3O4 and (b) MO-20. The solid lines correspond to the fitting with the Langevin equation (see text).

Mentions: VSM was performed to investigate the magnetic properties of Fe3O4 and MO-20 at room temperature. In Figure 4a, the hysteresis loops that are characteristic of superparamagnetic behavior can be observed for Fe3O4 nanoparticles. There is no hysteresis in the magnetization curve with both remanence and coercivity being zero, indicating that these magnetic nanoparticles are superparamagnetic. This feature is an important property needed for magnetic targeting carriers, because capillary blockage by aggregations formed by residue magnetism after removal of the applied field will be avoided [10]. The saturation magnetization of MO-20 (Figure 4b) is found to be 3.65 emu/g. This value is significatively lower than for magnetite nanoparticles (55 emu/g) reasonably due to the three coating layers of oleic acid, onco A and copolymer. Hu et al. [10] observed an 86% decrease in saturation magnetization with the addition of organic compounds on the surface of magnetite. Barreto et al. [13] observed a 94% decrease in saturation magnetization after encapsulation with quercetin and triblock copolymer. This feature renders the nanoparticles promising candidates for highly efficient magnetic manipulation when used as drug delivery carriers [28].


Magnetic nanosystem for cancer therapy using oncocalyxone a, an antitomour secondary metabolite isolated from a Brazilian plant.

Barreto AC, Santiago VR, Freire RM, Mazzetto SE, Denardin JC, Mele G, Cavalcante IM, Ribeiro ME, Ricardo NM, Gonçalves T, Carbone L, Lemos TL, Pessoa OD, Fechine PB - Int J Mol Sci (2013)

Magnetization curves of (a) Fe3O4 and (b) MO-20. The solid lines correspond to the fitting with the Langevin equation (see text).
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3794780&req=5

f4-ijms-14-18269: Magnetization curves of (a) Fe3O4 and (b) MO-20. The solid lines correspond to the fitting with the Langevin equation (see text).
Mentions: VSM was performed to investigate the magnetic properties of Fe3O4 and MO-20 at room temperature. In Figure 4a, the hysteresis loops that are characteristic of superparamagnetic behavior can be observed for Fe3O4 nanoparticles. There is no hysteresis in the magnetization curve with both remanence and coercivity being zero, indicating that these magnetic nanoparticles are superparamagnetic. This feature is an important property needed for magnetic targeting carriers, because capillary blockage by aggregations formed by residue magnetism after removal of the applied field will be avoided [10]. The saturation magnetization of MO-20 (Figure 4b) is found to be 3.65 emu/g. This value is significatively lower than for magnetite nanoparticles (55 emu/g) reasonably due to the three coating layers of oleic acid, onco A and copolymer. Hu et al. [10] observed an 86% decrease in saturation magnetization with the addition of organic compounds on the surface of magnetite. Barreto et al. [13] observed a 94% decrease in saturation magnetization after encapsulation with quercetin and triblock copolymer. This feature renders the nanoparticles promising candidates for highly efficient magnetic manipulation when used as drug delivery carriers [28].

Bottom Line: Onco A was associated with magnetite nanoparticles in order to obtain magnetic properties.The MO-20 presented a size of about 30 nm and globular morphology.In addition, drug releasing experiments were performed, where it was observed the presence of the anomalous transport.

View Article: PubMed Central - PubMed

Affiliation: Advanced Materials Chemistry Group (GQMAT), Analytical and Physical-Chemistry Department, Federal University of Ceará (UFC), Campus do Pici 12100, CEP 60451-970 Fortaleza-CE, Brazil. fechine@ufc.br.

ABSTRACT
This paper describes the investigation and development of a novel magnetic drug delivery nanosystem (labeled as MO-20) for cancer therapy. The drug employed was oncocalyxone A (onco A), which was isolated from Auxemma oncocalyx, an endemic Brazilian plant. It has a series of pharmacological properties: antioxidant, cytotoxic, analgesic, anti-inflammatory, antitumor and antiplatelet. Onco A was associated with magnetite nanoparticles in order to obtain magnetic properties. The components of MO-20 were characterized by XRD, FTIR, TGA, TEM and Magnetization curves. The MO-20 presented a size of about 30 nm and globular morphology. In addition, drug releasing experiments were performed, where it was observed the presence of the anomalous transport. The results found in this work showed the potential of onco A for future applications of the MO-20 as a new magnetic drug release nanosystem for cancer treatment.

Show MeSH