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Assessment of blood flow in hepatocellular carcinoma: correlations of computed tomography perfusion imaging and circulating angiogenic factors.

Chen YW, Pan HB, Tseng HH, Hung YT, Huang JS, Chou CP - Int J Mol Sci (2013)

Bottom Line: Total BF, arterial BF, portal BF, arterial fraction (arterial BF/total BF) of the HCC and surrounding liver parenchyma, and HCC-parenchyma ratio were measured using a dual-vessel model.After analyzing the correlations between BF in HCC and four circulating angiogenic factors, we found that the HCC-parenchyma ratio of arterial BF showed a significantly positive correlation with the level of circulating IL-8 (p < 0.05).This circulating biomarker, IL-8, provides a non-invasive tool for assessment of BF in HCC.

View Article: PubMed Central - PubMed

Affiliation: National Institute of Cancer Research, National Health Research Institutes, Miaoli 350, Taiwan. ywc@nhri.org.tw

ABSTRACT
Hepatocellular carcinoma (HCC) is a highly vascular tumor through the process of angiogenesis. To evaluate more non-invasive techniques for assessment of blood flow (BF) in HCC, this study examined the relationships between BF of HCC measured by computer tomography (CT) perfusion imaging and four circulating angiogenic factors in HCC patients. Interleukin 6 (IL-6), interleukin 8 (IL-8), vascular endothelial growth factor (VEGF), and platelet derived growth factor (PDGF) in plasma were measured using Bio-Plex multiplex immunoassay in 21 HCC patients and eight healthy controls. Circulating IL-6, IL-8 and VEGF showed higher concentrations in HCC patients than in controls (p < 0.05), and predicted HCC occurrence better than chance (p < 0.01). Twenty-one patients with HCC received 21-phase liver imaging using a 64-slice CT. Total BF, arterial BF, portal BF, arterial fraction (arterial BF/total BF) of the HCC and surrounding liver parenchyma, and HCC-parenchyma ratio were measured using a dual-vessel model. After analyzing the correlations between BF in HCC and four circulating angiogenic factors, we found that the HCC-parenchyma ratio of arterial BF showed a significantly positive correlation with the level of circulating IL-8 (p < 0.05). This circulating biomarker, IL-8, provides a non-invasive tool for assessment of BF in HCC.

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A correlation between the HCC-parenchyma ratio of arterial BF and level of circulating IL-8. There was a significant positive correlation (r = 0.46, p = 0.0357) between the HCC-parenchyma ratios of arterial BF and circulating IL-8. *p < 0.05.
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f5-ijms-14-17536: A correlation between the HCC-parenchyma ratio of arterial BF and level of circulating IL-8. There was a significant positive correlation (r = 0.46, p = 0.0357) between the HCC-parenchyma ratios of arterial BF and circulating IL-8. *p < 0.05.

Mentions: To delicately measure the change in BF between HCC and its surrounding liver parenchyma, we calculated the HCC-parenchyma ratio (HCC/parenchyma) of the BF parameters. After analyzing, there was a significantly positive correlation between the HCC-parenchyma ratios of arterial BF and level of circulating IL-8, indicating a higher IL-8 level in circulation was associated with higher arterial BF in HCC relative to the surrounding parenchyma (Figure 5 and Table 2, p = 0.0357). However, there was no significant correlation between the HCC-parenchyma ratios of CT perfusion parameters and other factors, including IL-6, VEGF, and PDGF (Table 2).


Assessment of blood flow in hepatocellular carcinoma: correlations of computed tomography perfusion imaging and circulating angiogenic factors.

Chen YW, Pan HB, Tseng HH, Hung YT, Huang JS, Chou CP - Int J Mol Sci (2013)

A correlation between the HCC-parenchyma ratio of arterial BF and level of circulating IL-8. There was a significant positive correlation (r = 0.46, p = 0.0357) between the HCC-parenchyma ratios of arterial BF and circulating IL-8. *p < 0.05.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3794740&req=5

f5-ijms-14-17536: A correlation between the HCC-parenchyma ratio of arterial BF and level of circulating IL-8. There was a significant positive correlation (r = 0.46, p = 0.0357) between the HCC-parenchyma ratios of arterial BF and circulating IL-8. *p < 0.05.
Mentions: To delicately measure the change in BF between HCC and its surrounding liver parenchyma, we calculated the HCC-parenchyma ratio (HCC/parenchyma) of the BF parameters. After analyzing, there was a significantly positive correlation between the HCC-parenchyma ratios of arterial BF and level of circulating IL-8, indicating a higher IL-8 level in circulation was associated with higher arterial BF in HCC relative to the surrounding parenchyma (Figure 5 and Table 2, p = 0.0357). However, there was no significant correlation between the HCC-parenchyma ratios of CT perfusion parameters and other factors, including IL-6, VEGF, and PDGF (Table 2).

Bottom Line: Total BF, arterial BF, portal BF, arterial fraction (arterial BF/total BF) of the HCC and surrounding liver parenchyma, and HCC-parenchyma ratio were measured using a dual-vessel model.After analyzing the correlations between BF in HCC and four circulating angiogenic factors, we found that the HCC-parenchyma ratio of arterial BF showed a significantly positive correlation with the level of circulating IL-8 (p < 0.05).This circulating biomarker, IL-8, provides a non-invasive tool for assessment of BF in HCC.

View Article: PubMed Central - PubMed

Affiliation: National Institute of Cancer Research, National Health Research Institutes, Miaoli 350, Taiwan. ywc@nhri.org.tw

ABSTRACT
Hepatocellular carcinoma (HCC) is a highly vascular tumor through the process of angiogenesis. To evaluate more non-invasive techniques for assessment of blood flow (BF) in HCC, this study examined the relationships between BF of HCC measured by computer tomography (CT) perfusion imaging and four circulating angiogenic factors in HCC patients. Interleukin 6 (IL-6), interleukin 8 (IL-8), vascular endothelial growth factor (VEGF), and platelet derived growth factor (PDGF) in plasma were measured using Bio-Plex multiplex immunoassay in 21 HCC patients and eight healthy controls. Circulating IL-6, IL-8 and VEGF showed higher concentrations in HCC patients than in controls (p < 0.05), and predicted HCC occurrence better than chance (p < 0.01). Twenty-one patients with HCC received 21-phase liver imaging using a 64-slice CT. Total BF, arterial BF, portal BF, arterial fraction (arterial BF/total BF) of the HCC and surrounding liver parenchyma, and HCC-parenchyma ratio were measured using a dual-vessel model. After analyzing the correlations between BF in HCC and four circulating angiogenic factors, we found that the HCC-parenchyma ratio of arterial BF showed a significantly positive correlation with the level of circulating IL-8 (p < 0.05). This circulating biomarker, IL-8, provides a non-invasive tool for assessment of BF in HCC.

Show MeSH
Related in: MedlinePlus