Limits...
Clinical and Capillaroscopic Modifications of the Psoriatic Plaque during Therapy: Observations with Oral Acitretin.

Stinco G, Buligan C, Errichetti E, Valent F, Patrone P - Dermatol Res Pract (2013)

Bottom Line: In the present work we evaluated the effects of acitretin (0.8 mg/kg/day) on videocapillaroscopic alterations and the clinical response in 11 patients affected by plaque psoriasis at the baseline (T0) and after 4 (T1), 8 (T2), and 12 (T3) weeks.The typical "basket-weave" capillaries of the psoriatic lesions showed a reduction of 65.4% in diameter at the end of the study; only 3 patients returned to a normal capillaroscopic pattern.As observed during previous our studies, we found a discrepancy between clinical and capillaroscopic results, with a far greater improvement in the first than in the second.

View Article: PubMed Central - PubMed

Affiliation: Department of Experimental and Clinical Medicine,Institute of Dermatology, University of Udine, Ospedale "San Michele" di Gemona, Piazza Rodolone 1, Gemona del Friuli, 33013 Udine, Italy.

ABSTRACT
Psoriasis is considered to be an inflammatory autoimmune disease, where angiogenesis plays an undefined pathogenetic role. The well-known changes of the superficial microvasculature in the psoriatic plaque can be easily assessed in vivo by videocapillaroscopy. In the last years, several studies reported the clinical and capillaroscopic response of the psoriatic plaque during different topical and systemic treatments. In the present work we evaluated the effects of acitretin (0.8 mg/kg/day) on videocapillaroscopic alterations and the clinical response in 11 patients affected by plaque psoriasis at the baseline (T0) and after 4 (T1), 8 (T2), and 12 (T3) weeks. A clinical improvement during the treatment with a complete clinical healing of the plaque in 7 of the 11 patients was observed. The typical "basket-weave" capillaries of the psoriatic lesions showed a reduction of 65.4% in diameter at the end of the study; only 3 patients returned to a normal capillaroscopic pattern. As observed during previous our studies, we found a discrepancy between clinical and capillaroscopic results, with a far greater improvement in the first than in the second. This finding could be in agreement with a secondary role of blood vessels in the pathogenesis and persistence of psoriatic lesions.

No MeSH data available.


Related in: MedlinePlus

Capillaroscopic image (a) of the centre of the psoriatic plaque (b) at T0.
© Copyright Policy - open-access
Related In: Results  -  Collection


getmorefigures.php?uid=PMC3794662&req=5

fig1: Capillaroscopic image (a) of the centre of the psoriatic plaque (b) at T0.

Mentions: The initial clinical evaluation (T0) of the plaque showed a mean score of 7.12 ± 0.50, while the mean diameter of capillaries was 70.02 ± 10.60 μm (Figure 1). At subsequent evaluations, the clinical improvement in erythema, infiltration, and scaling was evidenced with a score of 4.08 ± 0.62 at T1 (P < 0.0001) and 1.83 ± 0.45 at T2 (P < 0.0001). Also the “basket” diameter decreased from a mean value of 47.69 ± 7.22 μm at T1 (P < 0.0001) to 32.26 ± 8.33 μm at T2 (P = 0.0002).


Clinical and Capillaroscopic Modifications of the Psoriatic Plaque during Therapy: Observations with Oral Acitretin.

Stinco G, Buligan C, Errichetti E, Valent F, Patrone P - Dermatol Res Pract (2013)

Capillaroscopic image (a) of the centre of the psoriatic plaque (b) at T0.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3794662&req=5

fig1: Capillaroscopic image (a) of the centre of the psoriatic plaque (b) at T0.
Mentions: The initial clinical evaluation (T0) of the plaque showed a mean score of 7.12 ± 0.50, while the mean diameter of capillaries was 70.02 ± 10.60 μm (Figure 1). At subsequent evaluations, the clinical improvement in erythema, infiltration, and scaling was evidenced with a score of 4.08 ± 0.62 at T1 (P < 0.0001) and 1.83 ± 0.45 at T2 (P < 0.0001). Also the “basket” diameter decreased from a mean value of 47.69 ± 7.22 μm at T1 (P < 0.0001) to 32.26 ± 8.33 μm at T2 (P = 0.0002).

Bottom Line: In the present work we evaluated the effects of acitretin (0.8 mg/kg/day) on videocapillaroscopic alterations and the clinical response in 11 patients affected by plaque psoriasis at the baseline (T0) and after 4 (T1), 8 (T2), and 12 (T3) weeks.The typical "basket-weave" capillaries of the psoriatic lesions showed a reduction of 65.4% in diameter at the end of the study; only 3 patients returned to a normal capillaroscopic pattern.As observed during previous our studies, we found a discrepancy between clinical and capillaroscopic results, with a far greater improvement in the first than in the second.

View Article: PubMed Central - PubMed

Affiliation: Department of Experimental and Clinical Medicine,Institute of Dermatology, University of Udine, Ospedale "San Michele" di Gemona, Piazza Rodolone 1, Gemona del Friuli, 33013 Udine, Italy.

ABSTRACT
Psoriasis is considered to be an inflammatory autoimmune disease, where angiogenesis plays an undefined pathogenetic role. The well-known changes of the superficial microvasculature in the psoriatic plaque can be easily assessed in vivo by videocapillaroscopy. In the last years, several studies reported the clinical and capillaroscopic response of the psoriatic plaque during different topical and systemic treatments. In the present work we evaluated the effects of acitretin (0.8 mg/kg/day) on videocapillaroscopic alterations and the clinical response in 11 patients affected by plaque psoriasis at the baseline (T0) and after 4 (T1), 8 (T2), and 12 (T3) weeks. A clinical improvement during the treatment with a complete clinical healing of the plaque in 7 of the 11 patients was observed. The typical "basket-weave" capillaries of the psoriatic lesions showed a reduction of 65.4% in diameter at the end of the study; only 3 patients returned to a normal capillaroscopic pattern. As observed during previous our studies, we found a discrepancy between clinical and capillaroscopic results, with a far greater improvement in the first than in the second. This finding could be in agreement with a secondary role of blood vessels in the pathogenesis and persistence of psoriatic lesions.

No MeSH data available.


Related in: MedlinePlus