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The Protective Effect of Cordymin, a Peptide Purified from the Medicinal Mushroom Cordyceps sinensis, on Diabetic Osteopenia in Alloxan-Induced Diabetic Rats.

Qi W, Zhang Y, Yan YB, Lei W, Wu ZX, Liu N, Liu S, Shi L, Fan Y - Evid Based Complement Alternat Med (2013)

Bottom Line: Cordymin could restore the circulating blood glucose, glycosylated hemoglobin (HbA1c), serum alkaline phosphatase (ALP), tartrate resistant acid phosphatase (TRAP), and insulin levels in a dose-dependent manner.The results may directly and indirectly account for the possible mechanism of the beneficial effect of cordymin on diabetic osteopenia, which was confirmed with the increased bone mineral content (BMC) and bone mineral density (BMD) in diabetic rats (P < 0.05).All those findings indicate that cordymin may play a protective role in diabetic osteoporosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopedics, Xi Jing Hospital, The Fourth Military Medical University, Xi'an 710032, China ; The Surgery Department of 520th Hospital of PLA, Mian Yang 621000, China.

ABSTRACT
The aim of this study was to investigate the protective effect of cordymin on diabetic osteopenia in alloxan-induced diabetic rats and the possible mechanisms involved. The diabetic rats received daily intraperitoneal injection with cordymin (20, 50, and 100 mg/kg/day) for 5 weeks. Cordymin could restore the circulating blood glucose, glycosylated hemoglobin (HbA1c), serum alkaline phosphatase (ALP), tartrate resistant acid phosphatase (TRAP), and insulin levels in a dose-dependent manner. Also, the treatment of diabetic rats with cordymin could partially reverse the β cells death and decrease the total antioxidant status (TAOS) in the diabetic rats. The results may directly and indirectly account for the possible mechanism of the beneficial effect of cordymin on diabetic osteopenia, which was confirmed with the increased bone mineral content (BMC) and bone mineral density (BMD) in diabetic rats (P < 0.05). All those findings indicate that cordymin may play a protective role in diabetic osteoporosis.

No MeSH data available.


Related in: MedlinePlus

Effect of cordymin on bone mineral density (BMD). Values are shown as means ± SEM. *P < 0.05 versus alloxan group.
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fig5: Effect of cordymin on bone mineral density (BMD). Values are shown as means ± SEM. *P < 0.05 versus alloxan group.

Mentions: The BMC in the examined bones of the diabetic groups was significantly reduced compared to the results obtained for the controls. The administration of cordymin100 and cordymin50 to the diabetic animals increased significantly the BMC in the examined bones when compared to the diabetic group (Table 4). Meanwhile, cordymin at 100 mg/kg significantly increased the femur BMD in diabetic rats (P < 0.05) (Figure 5).


The Protective Effect of Cordymin, a Peptide Purified from the Medicinal Mushroom Cordyceps sinensis, on Diabetic Osteopenia in Alloxan-Induced Diabetic Rats.

Qi W, Zhang Y, Yan YB, Lei W, Wu ZX, Liu N, Liu S, Shi L, Fan Y - Evid Based Complement Alternat Med (2013)

Effect of cordymin on bone mineral density (BMD). Values are shown as means ± SEM. *P < 0.05 versus alloxan group.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3794654&req=5

fig5: Effect of cordymin on bone mineral density (BMD). Values are shown as means ± SEM. *P < 0.05 versus alloxan group.
Mentions: The BMC in the examined bones of the diabetic groups was significantly reduced compared to the results obtained for the controls. The administration of cordymin100 and cordymin50 to the diabetic animals increased significantly the BMC in the examined bones when compared to the diabetic group (Table 4). Meanwhile, cordymin at 100 mg/kg significantly increased the femur BMD in diabetic rats (P < 0.05) (Figure 5).

Bottom Line: Cordymin could restore the circulating blood glucose, glycosylated hemoglobin (HbA1c), serum alkaline phosphatase (ALP), tartrate resistant acid phosphatase (TRAP), and insulin levels in a dose-dependent manner.The results may directly and indirectly account for the possible mechanism of the beneficial effect of cordymin on diabetic osteopenia, which was confirmed with the increased bone mineral content (BMC) and bone mineral density (BMD) in diabetic rats (P < 0.05).All those findings indicate that cordymin may play a protective role in diabetic osteoporosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopedics, Xi Jing Hospital, The Fourth Military Medical University, Xi'an 710032, China ; The Surgery Department of 520th Hospital of PLA, Mian Yang 621000, China.

ABSTRACT
The aim of this study was to investigate the protective effect of cordymin on diabetic osteopenia in alloxan-induced diabetic rats and the possible mechanisms involved. The diabetic rats received daily intraperitoneal injection with cordymin (20, 50, and 100 mg/kg/day) for 5 weeks. Cordymin could restore the circulating blood glucose, glycosylated hemoglobin (HbA1c), serum alkaline phosphatase (ALP), tartrate resistant acid phosphatase (TRAP), and insulin levels in a dose-dependent manner. Also, the treatment of diabetic rats with cordymin could partially reverse the β cells death and decrease the total antioxidant status (TAOS) in the diabetic rats. The results may directly and indirectly account for the possible mechanism of the beneficial effect of cordymin on diabetic osteopenia, which was confirmed with the increased bone mineral content (BMC) and bone mineral density (BMD) in diabetic rats (P < 0.05). All those findings indicate that cordymin may play a protective role in diabetic osteoporosis.

No MeSH data available.


Related in: MedlinePlus