Limits...
Diagnosis of thymic clear cell carcinoma by cytology.

Lale SA, Tiscornia-Wasserman PG, Aziz M - Case Rep Pathol (2013)

Bottom Line: Few cases of clear-cell carcinoma of thymus have been documented (Truong et al., 1990 and Wolfe III et al., 1983).All these cases were diagnosed by histopathological examination of the tissue.Thymic carcinoma with clear cell features has an aggressive clinical behavior including our case, where it was already metastasized at the time of presentation.

View Article: PubMed Central - PubMed

Affiliation: Mercy Hospital, 800 Myrtle Street, Independence, KS 67301, USA.

ABSTRACT
Clear cell carcinoma of the thymus is a rare tumor. Few cases of clear-cell carcinoma of thymus have been documented (Truong et al., 1990 and Wolfe III et al., 1983). All these cases were diagnosed by histopathological examination of the tissue. Diagnosis of thymic clear cell carcinoma on cytology is extremely challenging. Here we report the first case of thymic clear cell carcinoma diagnosed by cytological examination of the pericardial fluid with the help of immunocytochemistry. Differential diagnosis included adenocarcinoma, mesothelioma, and thymic clear cell carcinoma. Thymic carcinoma with clear cell features has an aggressive clinical behavior including our case, where it was already metastasized at the time of presentation.

No MeSH data available.


Related in: MedlinePlus

H & E stained cell block (40x).
© Copyright Policy - open-access
Related In: Results  -  Collection


getmorefigures.php?uid=PMC3794649&req=5

fig2: H & E stained cell block (40x).

Mentions: The cell block preparation (Figures 1 and 2) showed a cellular tumor composed of clusters of highly malignant cells with focal glandular arrangement. Many cells revealed vacuolated cytoplasm, suggestive of signet ring appearance. Tumor cells revealed mitosis of more than ten per ten high power field. Immunocytochemical stains confirmed the epithelial origin of the tumor (CK7, EMA positive, and CK20 negative). Mucicarmine stain was negative, while PAS with diastase was positive in nonvacuolated cells, indicating the presence of glycogen, but not mucin (Figures 3(a)–3(f)). Tumor cells were focally positive for CA 19.9, CA 125, E-Cadherin, BER EP4, and CK5/6. Immunostains for TTF-1, Calretinin, B72.3, ER, P63, CDX-2, CD 99, and CD 117 were negative. This immunoprofile was most consistent with the rare variant of thymic carcinoma, the clear cell type.


Diagnosis of thymic clear cell carcinoma by cytology.

Lale SA, Tiscornia-Wasserman PG, Aziz M - Case Rep Pathol (2013)

H & E stained cell block (40x).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3794649&req=5

fig2: H & E stained cell block (40x).
Mentions: The cell block preparation (Figures 1 and 2) showed a cellular tumor composed of clusters of highly malignant cells with focal glandular arrangement. Many cells revealed vacuolated cytoplasm, suggestive of signet ring appearance. Tumor cells revealed mitosis of more than ten per ten high power field. Immunocytochemical stains confirmed the epithelial origin of the tumor (CK7, EMA positive, and CK20 negative). Mucicarmine stain was negative, while PAS with diastase was positive in nonvacuolated cells, indicating the presence of glycogen, but not mucin (Figures 3(a)–3(f)). Tumor cells were focally positive for CA 19.9, CA 125, E-Cadherin, BER EP4, and CK5/6. Immunostains for TTF-1, Calretinin, B72.3, ER, P63, CDX-2, CD 99, and CD 117 were negative. This immunoprofile was most consistent with the rare variant of thymic carcinoma, the clear cell type.

Bottom Line: Few cases of clear-cell carcinoma of thymus have been documented (Truong et al., 1990 and Wolfe III et al., 1983).All these cases were diagnosed by histopathological examination of the tissue.Thymic carcinoma with clear cell features has an aggressive clinical behavior including our case, where it was already metastasized at the time of presentation.

View Article: PubMed Central - PubMed

Affiliation: Mercy Hospital, 800 Myrtle Street, Independence, KS 67301, USA.

ABSTRACT
Clear cell carcinoma of the thymus is a rare tumor. Few cases of clear-cell carcinoma of thymus have been documented (Truong et al., 1990 and Wolfe III et al., 1983). All these cases were diagnosed by histopathological examination of the tissue. Diagnosis of thymic clear cell carcinoma on cytology is extremely challenging. Here we report the first case of thymic clear cell carcinoma diagnosed by cytological examination of the pericardial fluid with the help of immunocytochemistry. Differential diagnosis included adenocarcinoma, mesothelioma, and thymic clear cell carcinoma. Thymic carcinoma with clear cell features has an aggressive clinical behavior including our case, where it was already metastasized at the time of presentation.

No MeSH data available.


Related in: MedlinePlus