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Effects of Flavonoids from French Marigold (Florets of Tagetes patula L.) on Acute Inflammation Model.

Yasukawa K, Kasahara Y - Int J Inflam (2013)

Bottom Line: The major components patuletin and patulitrin were isolated from French marigold (florets of Tagetes patula).Oral administration of patuletin and patulitrin significantly suppressed hind-paw edema induced by carrageenin and histamine, while topical application of patuletin and patulitrin significantly inhibited ear edema induced by 12-O-tetradecanoylphorbol-13-acetate and arachidonic acid.These results suggest the anti-inflammatory efficacy of French marigold.

View Article: PubMed Central - PubMed

Affiliation: School of Pharmacy, Nihon University, Chiba 274-8555, Japan.

ABSTRACT
The major components patuletin and patulitrin were isolated from French marigold (florets of Tagetes patula). Patuletin and patulitrin were found to inhibit acute inflammation in mice. Oral administration of patuletin and patulitrin significantly suppressed hind-paw edema induced by carrageenin and histamine, while topical application of patuletin and patulitrin significantly inhibited ear edema induced by 12-O-tetradecanoylphorbol-13-acetate and arachidonic acid. Thus, oral and topical administration of patuletin and patulitrin inhibited acute inflammation in mice. These results suggest the anti-inflammatory efficacy of French marigold.

No MeSH data available.


Related in: MedlinePlus

Inhibitory effect of patulitrin on histamine-induced hind-paw edema in mice. Drugs were administered p.o. 30 min before histamine (5 μg). ⚫: control; ■: patulitrin 5 mg/kg; ▲: patulitrin 15 mg/kg; ▼: patulitrin 50 mg/kg; ♦: cyproheptadine 10 mg/kg. Significantly different from the control, *P < 0.05 or **P < 0.01. Each value represents the mean ± SD of 5. Significantly different from the control, *P < 0.05, **P < 0.01, or ***P < 0.001. Each value represents the mean ± SD of 5 mice.
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fig5: Inhibitory effect of patulitrin on histamine-induced hind-paw edema in mice. Drugs were administered p.o. 30 min before histamine (5 μg). ⚫: control; ■: patulitrin 5 mg/kg; ▲: patulitrin 15 mg/kg; ▼: patulitrin 50 mg/kg; ♦: cyproheptadine 10 mg/kg. Significantly different from the control, *P < 0.05 or **P < 0.01. Each value represents the mean ± SD of 5. Significantly different from the control, *P < 0.05, **P < 0.01, or ***P < 0.001. Each value represents the mean ± SD of 5 mice.

Mentions: Data are expressed as means ± standard deviation and were analyzed using Prism statistical software. Differences between groups (Figures 2, 3, 4, 5, 6, and 7) were analyzed by one-way ANOVA followed by correction with Tukey-Kramer test.


Effects of Flavonoids from French Marigold (Florets of Tagetes patula L.) on Acute Inflammation Model.

Yasukawa K, Kasahara Y - Int J Inflam (2013)

Inhibitory effect of patulitrin on histamine-induced hind-paw edema in mice. Drugs were administered p.o. 30 min before histamine (5 μg). ⚫: control; ■: patulitrin 5 mg/kg; ▲: patulitrin 15 mg/kg; ▼: patulitrin 50 mg/kg; ♦: cyproheptadine 10 mg/kg. Significantly different from the control, *P < 0.05 or **P < 0.01. Each value represents the mean ± SD of 5. Significantly different from the control, *P < 0.05, **P < 0.01, or ***P < 0.001. Each value represents the mean ± SD of 5 mice.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3794638&req=5

fig5: Inhibitory effect of patulitrin on histamine-induced hind-paw edema in mice. Drugs were administered p.o. 30 min before histamine (5 μg). ⚫: control; ■: patulitrin 5 mg/kg; ▲: patulitrin 15 mg/kg; ▼: patulitrin 50 mg/kg; ♦: cyproheptadine 10 mg/kg. Significantly different from the control, *P < 0.05 or **P < 0.01. Each value represents the mean ± SD of 5. Significantly different from the control, *P < 0.05, **P < 0.01, or ***P < 0.001. Each value represents the mean ± SD of 5 mice.
Mentions: Data are expressed as means ± standard deviation and were analyzed using Prism statistical software. Differences between groups (Figures 2, 3, 4, 5, 6, and 7) were analyzed by one-way ANOVA followed by correction with Tukey-Kramer test.

Bottom Line: The major components patuletin and patulitrin were isolated from French marigold (florets of Tagetes patula).Oral administration of patuletin and patulitrin significantly suppressed hind-paw edema induced by carrageenin and histamine, while topical application of patuletin and patulitrin significantly inhibited ear edema induced by 12-O-tetradecanoylphorbol-13-acetate and arachidonic acid.These results suggest the anti-inflammatory efficacy of French marigold.

View Article: PubMed Central - PubMed

Affiliation: School of Pharmacy, Nihon University, Chiba 274-8555, Japan.

ABSTRACT
The major components patuletin and patulitrin were isolated from French marigold (florets of Tagetes patula). Patuletin and patulitrin were found to inhibit acute inflammation in mice. Oral administration of patuletin and patulitrin significantly suppressed hind-paw edema induced by carrageenin and histamine, while topical application of patuletin and patulitrin significantly inhibited ear edema induced by 12-O-tetradecanoylphorbol-13-acetate and arachidonic acid. Thus, oral and topical administration of patuletin and patulitrin inhibited acute inflammation in mice. These results suggest the anti-inflammatory efficacy of French marigold.

No MeSH data available.


Related in: MedlinePlus