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Rhodiola rosea Impairs Acquisition and Expression of Conditioned Place Preference Induced by Cocaine.

Titomanlio F, Manzanedo C, Rodríguez-Arias M, Mattioli L, Perfumi M, Miñarro J, Aguilar MA - Evid Based Complement Alternat Med (2013)

Bottom Line: A novel approach to the treatment of adverse effects of drugs of abuse is one which makes use of natural products.Rhodiola did not induce motivational effects by itself but attenuated the acquisition and expression of cocaine-induced CPP.Moreover, it was found that RHO did not block reinstatement.

View Article: PubMed Central - PubMed

Affiliation: Pharmacognosy Unit, School of Pharmacy, University of Camerino, Via Madonna delle Carceri 9, 62032 Camerino, Italy.

ABSTRACT
A novel approach to the treatment of adverse effects of drugs of abuse is one which makes use of natural products. The present study investigated the effect of Rhodiola rosea L. hydroalcoholic extract (RHO) on cocaine-induced hyperactivity and conditioned place preference (CPP) in mice. In a first experiment, mice received RHO (15, 20 or 25 mg/kg, IG), cocaine (25 mg/kg, i.p.) (COC), or a combination of both drugs (COC + RHO15, COC + RHO20, and COC + RHO25), and their locomotor activity was evaluated. In a second experiment, the effects of RHO on the acquisition, expression, and reinstatement of cocaine CPP (induced by drug priming or social defeat stress) were evaluated. RHO alone did not increase activity but potentiated the hyperactivity induced by cocaine. Rhodiola did not induce motivational effects by itself but attenuated the acquisition and expression of cocaine-induced CPP. Moreover, it was found that RHO did not block reinstatement. The results indicate that RHO is effective in reducing the rewarding properties of cocaine but is ineffective in preventing priming or stress-induced cocaine reinstatement. In light of these findings, the benefits of Rhodiola rosea L. as a treatment of cocaine addiction would seem to be limited.

No MeSH data available.


Related in: MedlinePlus

Effects of RHO on the acquisition of cocaine-induced CPP. Mice (n = 11–13 per group) were treated with a vehicle IG, RHO (15, 20 or 25 mg/kg, IG), cocaine (Coc 25 mg/kg, IP), or RHO 15, 20 or 25 plus Coc. RHO was administered 60 min before each saline or cocaine injection. Immediately after this second injection mice were confined to the drug-paired compartment for the conditioning phase. Bars represent the time in seconds spent in the drug-paired compartment during preconditioning (white) and postconditioning (black). Values are means ± SEM. *P < 0.05; **P < 0.01; significant difference in the time spent in preconditioning versus postconditioning sessions.
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fig2: Effects of RHO on the acquisition of cocaine-induced CPP. Mice (n = 11–13 per group) were treated with a vehicle IG, RHO (15, 20 or 25 mg/kg, IG), cocaine (Coc 25 mg/kg, IP), or RHO 15, 20 or 25 plus Coc. RHO was administered 60 min before each saline or cocaine injection. Immediately after this second injection mice were confined to the drug-paired compartment for the conditioning phase. Bars represent the time in seconds spent in the drug-paired compartment during preconditioning (white) and postconditioning (black). Values are means ± SEM. *P < 0.05; **P < 0.01; significant difference in the time spent in preconditioning versus postconditioning sessions.

Mentions: The results regarding the effect of RHO on acquisition of cocaine-induced CPP are represented in Figure 2. The ANOVA revealed a significant effect of the variable days (F(1,88) = 7.240; P < 0.01) and the interaction treatment × days (F(7,88) = 4.210; P < 0.001). Bonferroni post hoc comparisons revealed that the groups Veh + Coc, RHO15 + Coc, and RHO25 + Coc spent more time in the drug-paired compartment in post-C than in pre-C (P < 0.05, P < 0.001 and P < 0.01, resp.). Thus, at the doses used, RHO did not exert motivational effects, and only that of 20 mg/kg was capable of impairing the acquisition of cocaine-induced CPP.


Rhodiola rosea Impairs Acquisition and Expression of Conditioned Place Preference Induced by Cocaine.

Titomanlio F, Manzanedo C, Rodríguez-Arias M, Mattioli L, Perfumi M, Miñarro J, Aguilar MA - Evid Based Complement Alternat Med (2013)

Effects of RHO on the acquisition of cocaine-induced CPP. Mice (n = 11–13 per group) were treated with a vehicle IG, RHO (15, 20 or 25 mg/kg, IG), cocaine (Coc 25 mg/kg, IP), or RHO 15, 20 or 25 plus Coc. RHO was administered 60 min before each saline or cocaine injection. Immediately after this second injection mice were confined to the drug-paired compartment for the conditioning phase. Bars represent the time in seconds spent in the drug-paired compartment during preconditioning (white) and postconditioning (black). Values are means ± SEM. *P < 0.05; **P < 0.01; significant difference in the time spent in preconditioning versus postconditioning sessions.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3794542&req=5

fig2: Effects of RHO on the acquisition of cocaine-induced CPP. Mice (n = 11–13 per group) were treated with a vehicle IG, RHO (15, 20 or 25 mg/kg, IG), cocaine (Coc 25 mg/kg, IP), or RHO 15, 20 or 25 plus Coc. RHO was administered 60 min before each saline or cocaine injection. Immediately after this second injection mice were confined to the drug-paired compartment for the conditioning phase. Bars represent the time in seconds spent in the drug-paired compartment during preconditioning (white) and postconditioning (black). Values are means ± SEM. *P < 0.05; **P < 0.01; significant difference in the time spent in preconditioning versus postconditioning sessions.
Mentions: The results regarding the effect of RHO on acquisition of cocaine-induced CPP are represented in Figure 2. The ANOVA revealed a significant effect of the variable days (F(1,88) = 7.240; P < 0.01) and the interaction treatment × days (F(7,88) = 4.210; P < 0.001). Bonferroni post hoc comparisons revealed that the groups Veh + Coc, RHO15 + Coc, and RHO25 + Coc spent more time in the drug-paired compartment in post-C than in pre-C (P < 0.05, P < 0.001 and P < 0.01, resp.). Thus, at the doses used, RHO did not exert motivational effects, and only that of 20 mg/kg was capable of impairing the acquisition of cocaine-induced CPP.

Bottom Line: A novel approach to the treatment of adverse effects of drugs of abuse is one which makes use of natural products.Rhodiola did not induce motivational effects by itself but attenuated the acquisition and expression of cocaine-induced CPP.Moreover, it was found that RHO did not block reinstatement.

View Article: PubMed Central - PubMed

Affiliation: Pharmacognosy Unit, School of Pharmacy, University of Camerino, Via Madonna delle Carceri 9, 62032 Camerino, Italy.

ABSTRACT
A novel approach to the treatment of adverse effects of drugs of abuse is one which makes use of natural products. The present study investigated the effect of Rhodiola rosea L. hydroalcoholic extract (RHO) on cocaine-induced hyperactivity and conditioned place preference (CPP) in mice. In a first experiment, mice received RHO (15, 20 or 25 mg/kg, IG), cocaine (25 mg/kg, i.p.) (COC), or a combination of both drugs (COC + RHO15, COC + RHO20, and COC + RHO25), and their locomotor activity was evaluated. In a second experiment, the effects of RHO on the acquisition, expression, and reinstatement of cocaine CPP (induced by drug priming or social defeat stress) were evaluated. RHO alone did not increase activity but potentiated the hyperactivity induced by cocaine. Rhodiola did not induce motivational effects by itself but attenuated the acquisition and expression of cocaine-induced CPP. Moreover, it was found that RHO did not block reinstatement. The results indicate that RHO is effective in reducing the rewarding properties of cocaine but is ineffective in preventing priming or stress-induced cocaine reinstatement. In light of these findings, the benefits of Rhodiola rosea L. as a treatment of cocaine addiction would seem to be limited.

No MeSH data available.


Related in: MedlinePlus