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The ratio of second to fourth digit length (2D:4D) and coronary artery disease in a Han Chinese population.

Wu XL, Yang DY, Chai WH, Jin ML, Zhou XC, Peng L, Zhao YS - Int J Med Sci (2013)

Bottom Line: There were no significant differences in age among the four groups.No relationship was found between 2D:4D and age (all, P >0.05).There were no significant differences in mean 2D:4D between women with CAD and controls.

View Article: PubMed Central - PubMed

Affiliation: 1. Institute of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China.

ABSTRACT

Background: The association between index finger to ring finger length ratio (2D:4D) and cardiac disorders has been reported, however it has not been discussed in terms of coronary artery disease (CAD). We investigated whether 2D:4D could be used as a marker for predisposition to CAD as assessed by coronary angiography in Chinese men and women.

Methods: This study included 1764 persons divided into 4 groups, 441 cases with CAD and 441 persons without CAD as control in each sex of the same age. Finger lengths were measured twice for both hands using electronic calipers. Student t test was used to detect the difference of 2D:4D among groups. The receiver operator characteristic curves (ROCs) were used to detect the diagnostic effect of 2D:4D for CAD.

Results: There were no significant differences in age among the four groups. A significant difference of 2D:4D ratios between right and left hand were observed only in men in both control and CAD groups. On the right hand in the control group and on both hands in the CAD group, the 2D:4D ratios were higher in women than in men (all, P < 0.001). In men with CAD, mean 2D:4D was higher than mean 2D:4D in control men (right hand 0.962±0.042:0.927±0.038; left hand 0.950±0.044:0.934±0.048; both hands, P < 0.001), but this was not observed in women. No relationship was found between 2D:4D and age (all, P >0.05). The area under the curve of right hand 2D:4D in male was 0.72 (95% CI 0.683-0.753, p<0.001), while it was 0.602 (95% CI 0.565-0.639, p<0.001) in left hand.

Conclusions: The present study showed an association between high 2D:4D ratio and CAD in both hands in men. There were no significant differences in mean 2D:4D between women with CAD and controls.

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Related in: MedlinePlus

The ROCs analyzing 2D:4D ratio and CAD in male. The ROCs analysis showed that area under the curve of 2D:4D in male was 0.72 and 0.602 in right and left hand respectively (all, p<0.001).
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Figure 1: The ROCs analyzing 2D:4D ratio and CAD in male. The ROCs analysis showed that area under the curve of 2D:4D in male was 0.72 and 0.602 in right and left hand respectively (all, p<0.001).

Mentions: The ROCs analysis showed that area under the curve of 2D:4D in right hand in male was 0.72 (95% CI 0.683-0.753, p<0.001), while it was 0.602 (95% CI 0.565-0.639, p<0.001) in left hand (Figure 1). The optimal cutoff point of digit ratio for CAD discrimination in male was 0.9505 in both hands with sensitivity 0f 57.8% and specificity of 68% in right hand, and 50.8% and 58.7% in left hand. But the area under the curve of both hands in female was not statistically significant.


The ratio of second to fourth digit length (2D:4D) and coronary artery disease in a Han Chinese population.

Wu XL, Yang DY, Chai WH, Jin ML, Zhou XC, Peng L, Zhao YS - Int J Med Sci (2013)

The ROCs analyzing 2D:4D ratio and CAD in male. The ROCs analysis showed that area under the curve of 2D:4D in male was 0.72 and 0.602 in right and left hand respectively (all, p<0.001).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3775119&req=5

Figure 1: The ROCs analyzing 2D:4D ratio and CAD in male. The ROCs analysis showed that area under the curve of 2D:4D in male was 0.72 and 0.602 in right and left hand respectively (all, p<0.001).
Mentions: The ROCs analysis showed that area under the curve of 2D:4D in right hand in male was 0.72 (95% CI 0.683-0.753, p<0.001), while it was 0.602 (95% CI 0.565-0.639, p<0.001) in left hand (Figure 1). The optimal cutoff point of digit ratio for CAD discrimination in male was 0.9505 in both hands with sensitivity 0f 57.8% and specificity of 68% in right hand, and 50.8% and 58.7% in left hand. But the area under the curve of both hands in female was not statistically significant.

Bottom Line: There were no significant differences in age among the four groups.No relationship was found between 2D:4D and age (all, P >0.05).There were no significant differences in mean 2D:4D between women with CAD and controls.

View Article: PubMed Central - PubMed

Affiliation: 1. Institute of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China.

ABSTRACT

Background: The association between index finger to ring finger length ratio (2D:4D) and cardiac disorders has been reported, however it has not been discussed in terms of coronary artery disease (CAD). We investigated whether 2D:4D could be used as a marker for predisposition to CAD as assessed by coronary angiography in Chinese men and women.

Methods: This study included 1764 persons divided into 4 groups, 441 cases with CAD and 441 persons without CAD as control in each sex of the same age. Finger lengths were measured twice for both hands using electronic calipers. Student t test was used to detect the difference of 2D:4D among groups. The receiver operator characteristic curves (ROCs) were used to detect the diagnostic effect of 2D:4D for CAD.

Results: There were no significant differences in age among the four groups. A significant difference of 2D:4D ratios between right and left hand were observed only in men in both control and CAD groups. On the right hand in the control group and on both hands in the CAD group, the 2D:4D ratios were higher in women than in men (all, P < 0.001). In men with CAD, mean 2D:4D was higher than mean 2D:4D in control men (right hand 0.962±0.042:0.927±0.038; left hand 0.950±0.044:0.934±0.048; both hands, P < 0.001), but this was not observed in women. No relationship was found between 2D:4D and age (all, P >0.05). The area under the curve of right hand 2D:4D in male was 0.72 (95% CI 0.683-0.753, p<0.001), while it was 0.602 (95% CI 0.565-0.639, p<0.001) in left hand.

Conclusions: The present study showed an association between high 2D:4D ratio and CAD in both hands in men. There were no significant differences in mean 2D:4D between women with CAD and controls.

Show MeSH
Related in: MedlinePlus