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Soft-tissue masses as presentation of non-Hodgkin's lymphoma in AIDS patients.

Corti M, Villafañe MF, Bistmans A, Campitelli A, Narbaitz M - An Bras Dermatol (2013 Jul-Aug)

Bottom Line: Generally, Non-Hodgkin lymphomas of the soft tissue present as large subcutaneous masses without evidence of nodal or skin involvement.We describe four cases of primary Non-Hodgkin lymphomas of the soft tissue in patients infected with the human immunodeficiency virus.Non-Hodgkin lymphomas should be included in the differential diagnosis of soft tissue masses in human immunodeficiency virus - seropositive patients.

View Article: PubMed Central - PubMed

Affiliation: HIV/AIDS Department, Infectious Diseases, F. J. Muñiz Hospital, Buenos Aires, Argentina.

ABSTRACT
Primary soft tissue Non-Hodgkin lymphomas are very rare and account only for 0.1 % of the cases. Generally, Non-Hodgkin lymphomas of the soft tissue present as large subcutaneous masses without evidence of nodal or skin involvement. We describe four cases of primary Non-Hodgkin lymphomas of the soft tissue in patients infected with the human immunodeficiency virus. The most common site of involvement was the chest wall in all the patients; histopathological and immunophenotypic examination of the biopsy smears revealed two cases of plasmablastic lymphomas, one Burkitt and one diffuse large B-cell lymphoma. Non-Hodgkin lymphomas should be included in the differential diagnosis of soft tissue masses in human immunodeficiency virus - seropositive patients.

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A large soft tissue mass involving the subcutaneous and musculoskeletal tissue onthe chest wall. There is no evidence of regional nodal infiltration.
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f03: A large soft tissue mass involving the subcutaneous and musculoskeletal tissue onthe chest wall. There is no evidence of regional nodal infiltration.

Mentions: The incidence of NHL including DLBCL, Burkitt's lymphoma and PBL is increased amongHIVseropositive patients and 16% of deaths in AIDS patients have been associated withlymphomas.2The incidence of NHLin HIV patients is 3% and the lesions usually are of high-grade and with extranodalinvolvement as clinical presentation. About 70% of AIDS-associated lymphomas areNHL.1,2The incidence of extranodal NHL of the soft tissues is low andaccount only for 0.1% of the cases.3,4Soft tissue lymphomas at presentation areconsidered to be primary only if the staging procedures exclude other diseasesites.3Soft tissue lymphomasinclude those masses that involve the subcutaneous and the musculoskeletal tissues; inour experience, these neoplasms are characterized by fast growth with frequentinvolvement of the adjacent tissues, such as the skin and bone (Figure 3).3


Soft-tissue masses as presentation of non-Hodgkin's lymphoma in AIDS patients.

Corti M, Villafañe MF, Bistmans A, Campitelli A, Narbaitz M - An Bras Dermatol (2013 Jul-Aug)

A large soft tissue mass involving the subcutaneous and musculoskeletal tissue onthe chest wall. There is no evidence of regional nodal infiltration.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3760945&req=5

f03: A large soft tissue mass involving the subcutaneous and musculoskeletal tissue onthe chest wall. There is no evidence of regional nodal infiltration.
Mentions: The incidence of NHL including DLBCL, Burkitt's lymphoma and PBL is increased amongHIVseropositive patients and 16% of deaths in AIDS patients have been associated withlymphomas.2The incidence of NHLin HIV patients is 3% and the lesions usually are of high-grade and with extranodalinvolvement as clinical presentation. About 70% of AIDS-associated lymphomas areNHL.1,2The incidence of extranodal NHL of the soft tissues is low andaccount only for 0.1% of the cases.3,4Soft tissue lymphomas at presentation areconsidered to be primary only if the staging procedures exclude other diseasesites.3Soft tissue lymphomasinclude those masses that involve the subcutaneous and the musculoskeletal tissues; inour experience, these neoplasms are characterized by fast growth with frequentinvolvement of the adjacent tissues, such as the skin and bone (Figure 3).3

Bottom Line: Generally, Non-Hodgkin lymphomas of the soft tissue present as large subcutaneous masses without evidence of nodal or skin involvement.We describe four cases of primary Non-Hodgkin lymphomas of the soft tissue in patients infected with the human immunodeficiency virus.Non-Hodgkin lymphomas should be included in the differential diagnosis of soft tissue masses in human immunodeficiency virus - seropositive patients.

View Article: PubMed Central - PubMed

Affiliation: HIV/AIDS Department, Infectious Diseases, F. J. Muñiz Hospital, Buenos Aires, Argentina.

ABSTRACT
Primary soft tissue Non-Hodgkin lymphomas are very rare and account only for 0.1 % of the cases. Generally, Non-Hodgkin lymphomas of the soft tissue present as large subcutaneous masses without evidence of nodal or skin involvement. We describe four cases of primary Non-Hodgkin lymphomas of the soft tissue in patients infected with the human immunodeficiency virus. The most common site of involvement was the chest wall in all the patients; histopathological and immunophenotypic examination of the biopsy smears revealed two cases of plasmablastic lymphomas, one Burkitt and one diffuse large B-cell lymphoma. Non-Hodgkin lymphomas should be included in the differential diagnosis of soft tissue masses in human immunodeficiency virus - seropositive patients.

Show MeSH
Related in: MedlinePlus