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Circumscribed palmoplantar hypokeratosis: report of two Brazilian cases.

Rocha LK, Nico MM - An Bras Dermatol (2013 Jul-Aug)

Bottom Line: The clinical differential diagnosis includes mainly porokeratosis and Bowen's disease.Its pathogenesis remains unknown, but studies have proposed a human papillomavirus induced disease or a localized keratinization disorder in the palmoplantar area.We report herein two cases of patients with lesions clinically and microscopically compatible with the diagnosis of circumscribed palmoplantar hypokeratosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Medical School, University of São Paulo, São Paulo, Brazil.

ABSTRACT
Circumscribed palmoplantar hypokeratosis is a recently recognized dermatosis and rarely reported. It was first described in 2002 and is characterized by localized loss of the horny layer in the palmoplantar area. This dermatosis is clinically presented with a sharply circumscribed, reddish and asymptomatic plaque with slightly depressed surface localized on the palms or the soles. The clinical differential diagnosis includes mainly porokeratosis and Bowen's disease. Its pathogenesis remains unknown, but studies have proposed a human papillomavirus induced disease or a localized keratinization disorder in the palmoplantar area. We report herein two cases of patients with lesions clinically and microscopically compatible with the diagnosis of circumscribed palmoplantar hypokeratosis. We also present a brief literature review of the etiopathogenic hyphoteses of this dermatosis.

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Related in: MedlinePlus

Reddish, nummular and depressed lesion, located on the thenar eminence of the leftpalm (Case 2)
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f04: Reddish, nummular and depressed lesion, located on the thenar eminence of the leftpalm (Case 2)

Mentions: Case 2: Female patient, 84 years old, white, had had a single lesion on the left palmfor over 24 years. The patient had no history of trauma or local infection. The physicalexamination revealed a reddish, nummular, depressed and circumscribed patch, about 5 mmin diameter, located over the thenar eminence of the left palm (Figures 4 and 5). There wereno lesions on contralateral palm or on soles.


Circumscribed palmoplantar hypokeratosis: report of two Brazilian cases.

Rocha LK, Nico MM - An Bras Dermatol (2013 Jul-Aug)

Reddish, nummular and depressed lesion, located on the thenar eminence of the leftpalm (Case 2)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3760943&req=5

f04: Reddish, nummular and depressed lesion, located on the thenar eminence of the leftpalm (Case 2)
Mentions: Case 2: Female patient, 84 years old, white, had had a single lesion on the left palmfor over 24 years. The patient had no history of trauma or local infection. The physicalexamination revealed a reddish, nummular, depressed and circumscribed patch, about 5 mmin diameter, located over the thenar eminence of the left palm (Figures 4 and 5). There wereno lesions on contralateral palm or on soles.

Bottom Line: The clinical differential diagnosis includes mainly porokeratosis and Bowen's disease.Its pathogenesis remains unknown, but studies have proposed a human papillomavirus induced disease or a localized keratinization disorder in the palmoplantar area.We report herein two cases of patients with lesions clinically and microscopically compatible with the diagnosis of circumscribed palmoplantar hypokeratosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Medical School, University of São Paulo, São Paulo, Brazil.

ABSTRACT
Circumscribed palmoplantar hypokeratosis is a recently recognized dermatosis and rarely reported. It was first described in 2002 and is characterized by localized loss of the horny layer in the palmoplantar area. This dermatosis is clinically presented with a sharply circumscribed, reddish and asymptomatic plaque with slightly depressed surface localized on the palms or the soles. The clinical differential diagnosis includes mainly porokeratosis and Bowen's disease. Its pathogenesis remains unknown, but studies have proposed a human papillomavirus induced disease or a localized keratinization disorder in the palmoplantar area. We report herein two cases of patients with lesions clinically and microscopically compatible with the diagnosis of circumscribed palmoplantar hypokeratosis. We also present a brief literature review of the etiopathogenic hyphoteses of this dermatosis.

Show MeSH
Related in: MedlinePlus