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Circumscribed palmoplantar hypokeratosis: report of two Brazilian cases.

Rocha LK, Nico MM - An Bras Dermatol (2013 Jul-Aug)

Bottom Line: The clinical differential diagnosis includes mainly porokeratosis and Bowen's disease.Its pathogenesis remains unknown, but studies have proposed a human papillomavirus induced disease or a localized keratinization disorder in the palmoplantar area.We report herein two cases of patients with lesions clinically and microscopically compatible with the diagnosis of circumscribed palmoplantar hypokeratosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Medical School, University of São Paulo, São Paulo, Brazil.

ABSTRACT
Circumscribed palmoplantar hypokeratosis is a recently recognized dermatosis and rarely reported. It was first described in 2002 and is characterized by localized loss of the horny layer in the palmoplantar area. This dermatosis is clinically presented with a sharply circumscribed, reddish and asymptomatic plaque with slightly depressed surface localized on the palms or the soles. The clinical differential diagnosis includes mainly porokeratosis and Bowen's disease. Its pathogenesis remains unknown, but studies have proposed a human papillomavirus induced disease or a localized keratinization disorder in the palmoplantar area. We report herein two cases of patients with lesions clinically and microscopically compatible with the diagnosis of circumscribed palmoplantar hypokeratosis. We also present a brief literature review of the etiopathogenic hyphoteses of this dermatosis.

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Related in: MedlinePlus

Detail of the right palm lesion (Case 1)
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f02: Detail of the right palm lesion (Case 1)

Mentions: Case 1: Female patient, 68 years old, white, had had lesions on the palms for 30 years.There was no history of trauma or local infection. The dermatological exam showed tworeddish plaques of approximately 5x5mm on the right palm and 5x10mm on the left palm.The lesions were circumscribed, nummular, depressed and located symmetrically over thethenar regions (Figures 1 and 2). Her soles were not involved. The general clinical examinationwas not significant. Direct mycological examination was performed with negative results,and histopathological aspects of skin biopsy showed a focus of sharp decrease in thestratum corneum thickness, mild acanthosis and no change in the basal layer (Figure 3).


Circumscribed palmoplantar hypokeratosis: report of two Brazilian cases.

Rocha LK, Nico MM - An Bras Dermatol (2013 Jul-Aug)

Detail of the right palm lesion (Case 1)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3760943&req=5

f02: Detail of the right palm lesion (Case 1)
Mentions: Case 1: Female patient, 68 years old, white, had had lesions on the palms for 30 years.There was no history of trauma or local infection. The dermatological exam showed tworeddish plaques of approximately 5x5mm on the right palm and 5x10mm on the left palm.The lesions were circumscribed, nummular, depressed and located symmetrically over thethenar regions (Figures 1 and 2). Her soles were not involved. The general clinical examinationwas not significant. Direct mycological examination was performed with negative results,and histopathological aspects of skin biopsy showed a focus of sharp decrease in thestratum corneum thickness, mild acanthosis and no change in the basal layer (Figure 3).

Bottom Line: The clinical differential diagnosis includes mainly porokeratosis and Bowen's disease.Its pathogenesis remains unknown, but studies have proposed a human papillomavirus induced disease or a localized keratinization disorder in the palmoplantar area.We report herein two cases of patients with lesions clinically and microscopically compatible with the diagnosis of circumscribed palmoplantar hypokeratosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, Medical School, University of São Paulo, São Paulo, Brazil.

ABSTRACT
Circumscribed palmoplantar hypokeratosis is a recently recognized dermatosis and rarely reported. It was first described in 2002 and is characterized by localized loss of the horny layer in the palmoplantar area. This dermatosis is clinically presented with a sharply circumscribed, reddish and asymptomatic plaque with slightly depressed surface localized on the palms or the soles. The clinical differential diagnosis includes mainly porokeratosis and Bowen's disease. Its pathogenesis remains unknown, but studies have proposed a human papillomavirus induced disease or a localized keratinization disorder in the palmoplantar area. We report herein two cases of patients with lesions clinically and microscopically compatible with the diagnosis of circumscribed palmoplantar hypokeratosis. We also present a brief literature review of the etiopathogenic hyphoteses of this dermatosis.

Show MeSH
Related in: MedlinePlus