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Review: dermatitis herpetiformis.

Mendes FB, Hissa-Elian A, Abreu MA, Gonçalves VS - An Bras Dermatol (2013 Jul-Aug)

Bottom Line: The same protein IgA1 with J chain is found in the small intestinal mucosa in patients with adult celiac disease, suggesting a strong association with DH.Autoimmune diseases present higher levels of prevalence, such as thyroid (5-11%), pernicious anemia (1-3%), type 1 diabetes (1-2%) and collagen tissue disease.The chosen treatment is dapsone and a gluten-free diet.

View Article: PubMed Central - PubMed

Affiliation: Presidente Prudente Regional Hospital, University of Oeste Paulista, Presidente Prudente(SP),Brazil.

ABSTRACT
Dermatitis herpetiformis (DH) or Duhring-Brocq disease is a chronic bullous disease characterized by intense itching and burning sensation in the erythematous papules and urticarial plaques, grouped vesicles with centrifuge growth, and tense blisters. There is an association with the genotypes HLA DR3, HLA DQw2, found in 80-90% of cases. It is an IgA-mediated cutaneous disease, with immunoglobulin A deposits appearing in a granular pattern at the top of the dermal papilla in the sublamina densa area of the basement membrane, which is present both in affected skin and healthy skin. The same protein IgA1 with J chain is found in the small intestinal mucosa in patients with adult celiac disease, suggesting a strong association with DH. Specific antibodies such as antiendomysium, antireticulina, antigliadin and, recently identified, the epidermal and tissue transglutaminase subtypes, as well as increased zonulin production, are common to both conditions, along with gluten-sensitive enteropathy and DH. Autoimmune diseases present higher levels of prevalence, such as thyroid (5-11%), pernicious anemia (1-3%), type 1 diabetes (1-2%) and collagen tissue disease. The chosen treatment is dapsone and a gluten-free diet.

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Related in: MedlinePlus

Dermatitis herpetiformis. Vesicles dissected with crusts and residualhypopigmented macules on the knees
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Related In: Results  -  Collection

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f02: Dermatitis herpetiformis. Vesicles dissected with crusts and residualhypopigmented macules on the knees

Mentions: Cutaneous lesions begin with itching or a burning sensation in erythematous papules andurticarial plaques. There are grouped vesicles and tense blisters with centrifugalgrowth, whose contents may be serous or hemorrhagic, with symmetrical distribution(Figures 1, 2 and 3). 3,6,8,17,18 Bullous elements rupture, culminating in denuded areasof exulcerated skin and crust. Subsequently, there is residual hypopigmentation orhyperpigmentation. 8,16


Review: dermatitis herpetiformis.

Mendes FB, Hissa-Elian A, Abreu MA, Gonçalves VS - An Bras Dermatol (2013 Jul-Aug)

Dermatitis herpetiformis. Vesicles dissected with crusts and residualhypopigmented macules on the knees
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3760935&req=5

f02: Dermatitis herpetiformis. Vesicles dissected with crusts and residualhypopigmented macules on the knees
Mentions: Cutaneous lesions begin with itching or a burning sensation in erythematous papules andurticarial plaques. There are grouped vesicles and tense blisters with centrifugalgrowth, whose contents may be serous or hemorrhagic, with symmetrical distribution(Figures 1, 2 and 3). 3,6,8,17,18 Bullous elements rupture, culminating in denuded areasof exulcerated skin and crust. Subsequently, there is residual hypopigmentation orhyperpigmentation. 8,16

Bottom Line: The same protein IgA1 with J chain is found in the small intestinal mucosa in patients with adult celiac disease, suggesting a strong association with DH.Autoimmune diseases present higher levels of prevalence, such as thyroid (5-11%), pernicious anemia (1-3%), type 1 diabetes (1-2%) and collagen tissue disease.The chosen treatment is dapsone and a gluten-free diet.

View Article: PubMed Central - PubMed

Affiliation: Presidente Prudente Regional Hospital, University of Oeste Paulista, Presidente Prudente(SP),Brazil.

ABSTRACT
Dermatitis herpetiformis (DH) or Duhring-Brocq disease is a chronic bullous disease characterized by intense itching and burning sensation in the erythematous papules and urticarial plaques, grouped vesicles with centrifuge growth, and tense blisters. There is an association with the genotypes HLA DR3, HLA DQw2, found in 80-90% of cases. It is an IgA-mediated cutaneous disease, with immunoglobulin A deposits appearing in a granular pattern at the top of the dermal papilla in the sublamina densa area of the basement membrane, which is present both in affected skin and healthy skin. The same protein IgA1 with J chain is found in the small intestinal mucosa in patients with adult celiac disease, suggesting a strong association with DH. Specific antibodies such as antiendomysium, antireticulina, antigliadin and, recently identified, the epidermal and tissue transglutaminase subtypes, as well as increased zonulin production, are common to both conditions, along with gluten-sensitive enteropathy and DH. Autoimmune diseases present higher levels of prevalence, such as thyroid (5-11%), pernicious anemia (1-3%), type 1 diabetes (1-2%) and collagen tissue disease. The chosen treatment is dapsone and a gluten-free diet.

Show MeSH
Related in: MedlinePlus