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Epidemiological and histopathological profile of cutaneous melanoma at a center in northeastern Brazil from 2000 to 2010.

Vilanova CM, Lages RB, Ribeiro SM, Almeida IP, Santos LG, Vieira SC - An Bras Dermatol (2013 Jul-Aug)

Bottom Line: Histological types found were nodular (52.8%), superficial spreading melanoma (18.6%), acral (10.6%) and lentigo maligna (9.5%).Metastasis was found in 28.6% of invasive melanomas and nodular melanoma, Clark IV/ V, Breslow > 1 mm, mitotic index > 6 and ulcerated lesions were more likely to metastasize.The main factors associated with metastasis were nodular type, Clark IV / V, Breslow > 1mm, mitotic index > 6 and ulcerated lesions.

View Article: PubMed Central - PubMed

Affiliation: Piauí Federal University, TeresinaPI, Brazil.

ABSTRACT

Background: While representing only 3-4% of malignant skin tumors, cutaneous melanoma is the most aggressive and lethal. Statistical knowledge about the biological behavior of this tumor is essential for guiding daily outpatient practice and aiding public health policies.

Objectives: To analyze the profile of patients with cutaneous melanoma attending a pathology department in Teresina (state of Piauí) between 2000 and 2010.

Methods: Retrospective study of melanoma patients diagnosed between 2000 and 2010 in the São Marcos Hospital in the city of Teresina. The pathology laboratory reports were studied and all the statistical analyses performed using SPSS 19.0.

Results: A total of 25 in situ, 199 invasive and 89 metastatic melanomas of unknown primary site were observed. Histological types found were nodular (52.8%), superficial spreading melanoma (18.6%), acral (10.6%) and lentigo maligna (9.5%). In 144 (73.4%) cases the Breslow thickness was >1 mm. Metastasis was found in 28.6% of invasive melanomas and nodular melanoma, Clark IV/ V, Breslow > 1 mm, mitotic index > 6 and ulcerated lesions were more likely to metastasize.

Conclusion: Most melanomas presented Breslow> 1mm. The main factors associated with metastasis were nodular type, Clark IV / V, Breslow > 1mm, mitotic index > 6 and ulcerated lesions.

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Related in: MedlinePlus

Distribution of invasive cutaneous melanomas diagnosed per year in a pathologyreference service in Teresina (Piauí), according to histological type,2000-2010
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f01: Distribution of invasive cutaneous melanomas diagnosed per year in a pathologyreference service in Teresina (Piauí), according to histological type,2000-2010

Mentions: A total of 313 patients were included in the analysis: 25 (7.9%) were in situcutaneous melanoma (CM), 199 (63.6%) were invasive CM and 89 (28.4%) weremetastatic CM. Concerning histological type in the invasive group, nodular melanoma wasfound in 105 cases (52.8%), superficial spreading melanoma in 37 cases (18.6%),acral-lentiginous melanoma in 21 cases (10.6%) and lentigo maligna melanoma in 19 cases(9.5%). Other types of CM were found in 5 cases (2.5%) (Table 1). Graph 1 shows thedistribution of cases according to histological type per year.


Epidemiological and histopathological profile of cutaneous melanoma at a center in northeastern Brazil from 2000 to 2010.

Vilanova CM, Lages RB, Ribeiro SM, Almeida IP, Santos LG, Vieira SC - An Bras Dermatol (2013 Jul-Aug)

Distribution of invasive cutaneous melanomas diagnosed per year in a pathologyreference service in Teresina (Piauí), according to histological type,2000-2010
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3760929&req=5

f01: Distribution of invasive cutaneous melanomas diagnosed per year in a pathologyreference service in Teresina (Piauí), according to histological type,2000-2010
Mentions: A total of 313 patients were included in the analysis: 25 (7.9%) were in situcutaneous melanoma (CM), 199 (63.6%) were invasive CM and 89 (28.4%) weremetastatic CM. Concerning histological type in the invasive group, nodular melanoma wasfound in 105 cases (52.8%), superficial spreading melanoma in 37 cases (18.6%),acral-lentiginous melanoma in 21 cases (10.6%) and lentigo maligna melanoma in 19 cases(9.5%). Other types of CM were found in 5 cases (2.5%) (Table 1). Graph 1 shows thedistribution of cases according to histological type per year.

Bottom Line: Histological types found were nodular (52.8%), superficial spreading melanoma (18.6%), acral (10.6%) and lentigo maligna (9.5%).Metastasis was found in 28.6% of invasive melanomas and nodular melanoma, Clark IV/ V, Breslow > 1 mm, mitotic index > 6 and ulcerated lesions were more likely to metastasize.The main factors associated with metastasis were nodular type, Clark IV / V, Breslow > 1mm, mitotic index > 6 and ulcerated lesions.

View Article: PubMed Central - PubMed

Affiliation: Piauí Federal University, TeresinaPI, Brazil.

ABSTRACT

Background: While representing only 3-4% of malignant skin tumors, cutaneous melanoma is the most aggressive and lethal. Statistical knowledge about the biological behavior of this tumor is essential for guiding daily outpatient practice and aiding public health policies.

Objectives: To analyze the profile of patients with cutaneous melanoma attending a pathology department in Teresina (state of Piauí) between 2000 and 2010.

Methods: Retrospective study of melanoma patients diagnosed between 2000 and 2010 in the São Marcos Hospital in the city of Teresina. The pathology laboratory reports were studied and all the statistical analyses performed using SPSS 19.0.

Results: A total of 25 in situ, 199 invasive and 89 metastatic melanomas of unknown primary site were observed. Histological types found were nodular (52.8%), superficial spreading melanoma (18.6%), acral (10.6%) and lentigo maligna (9.5%). In 144 (73.4%) cases the Breslow thickness was >1 mm. Metastasis was found in 28.6% of invasive melanomas and nodular melanoma, Clark IV/ V, Breslow > 1 mm, mitotic index > 6 and ulcerated lesions were more likely to metastasize.

Conclusion: Most melanomas presented Breslow> 1mm. The main factors associated with metastasis were nodular type, Clark IV / V, Breslow > 1mm, mitotic index > 6 and ulcerated lesions.

Show MeSH
Related in: MedlinePlus