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Colonization by S. aureus increases the EASI and the number of appointments by patients with atopic dermatitis: cohort with 93 patients.

Lipnharski C, d'Azevedo PA, Quinto VP, Bessa G, Bonamigo RR - An Bras Dermatol (2013 Jul-Aug)

Bottom Line: There was linear correlation between the number of appointments during one year and the inicial Eczema Area and Severity Index (r = 0,78).There were no patients with methicillin resistant Staphylococcus aureus acquired in the community.Methicillin resistance among those affected by S. aureus does not seem to be an emergent problem, in this Brazilian sample.

View Article: PubMed Central - PubMed

Affiliation: Universidade de Ciências da Saúde de Porto Alegre, Porto AlegreRSBrazil.

ABSTRACT

Background: Atopic dermatitis leads to epidermal barrier dysfunction and bacteria colonization. The relationship of the last factor with the severity of the disease and the frequency of exacerbation is not fully known.

Objectives: Verify the severity of the atopic dermatitis and the number of appointments generated by dermatosis, comparing patients colonized with patients not colonized by S. aureus. Verify the frequency of colonization by methicillin resistant Staphylococcus aureus acquired in the community.

Methods: Cohort study with a 12 months follow-up, in a sample of patients from Porto Alegre, RS public network. Cultures in active injuries and nasal cavities were carried out as well as methicillin sensitivity tests to S. aureus. The severity of atopic dermatitis was defined by Eczema Area and Severity Index (EASI).

Results: We included 93 patients, 43% female and 56% male, 26 colonized by S. aureus in the nasal orifices, 56 in the skin damage. The mean of initial Eczema Area and Severity Index was 5.5 and final 3.9. The initial Eczema Area and Severity Index of patients colonized by S. aureus in the skin and nasal cavity was larger than the number of patients without colonization(p< 0.05). During the period of one year, in average, there were six appointments/patient. There was linear correlation between the number of appointments during one year and the inicial Eczema Area and Severity Index (r = 0,78). There were no patients with methicillin resistant Staphylococcus aureus acquired in the community.

Conclusion: There is a relevant influence of staphylococcal colonization on the severity of atopic dermatitis and the number of appointments required by its exacerbation. Methicillin resistance among those affected by S. aureus does not seem to be an emergent problem, in this Brazilian sample.

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Initial EASI and colonization by S. aureus in the nasalcavities
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f02: Initial EASI and colonization by S. aureus in the nasalcavities

Mentions: Graph 2 shows the comparison of SAN patients inrelation to non colonized (p = 0.0059).


Colonization by S. aureus increases the EASI and the number of appointments by patients with atopic dermatitis: cohort with 93 patients.

Lipnharski C, d'Azevedo PA, Quinto VP, Bessa G, Bonamigo RR - An Bras Dermatol (2013 Jul-Aug)

Initial EASI and colonization by S. aureus in the nasalcavities
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3760925&req=5

f02: Initial EASI and colonization by S. aureus in the nasalcavities
Mentions: Graph 2 shows the comparison of SAN patients inrelation to non colonized (p = 0.0059).

Bottom Line: There was linear correlation between the number of appointments during one year and the inicial Eczema Area and Severity Index (r = 0,78).There were no patients with methicillin resistant Staphylococcus aureus acquired in the community.Methicillin resistance among those affected by S. aureus does not seem to be an emergent problem, in this Brazilian sample.

View Article: PubMed Central - PubMed

Affiliation: Universidade de Ciências da Saúde de Porto Alegre, Porto AlegreRSBrazil.

ABSTRACT

Background: Atopic dermatitis leads to epidermal barrier dysfunction and bacteria colonization. The relationship of the last factor with the severity of the disease and the frequency of exacerbation is not fully known.

Objectives: Verify the severity of the atopic dermatitis and the number of appointments generated by dermatosis, comparing patients colonized with patients not colonized by S. aureus. Verify the frequency of colonization by methicillin resistant Staphylococcus aureus acquired in the community.

Methods: Cohort study with a 12 months follow-up, in a sample of patients from Porto Alegre, RS public network. Cultures in active injuries and nasal cavities were carried out as well as methicillin sensitivity tests to S. aureus. The severity of atopic dermatitis was defined by Eczema Area and Severity Index (EASI).

Results: We included 93 patients, 43% female and 56% male, 26 colonized by S. aureus in the nasal orifices, 56 in the skin damage. The mean of initial Eczema Area and Severity Index was 5.5 and final 3.9. The initial Eczema Area and Severity Index of patients colonized by S. aureus in the skin and nasal cavity was larger than the number of patients without colonization(p< 0.05). During the period of one year, in average, there were six appointments/patient. There was linear correlation between the number of appointments during one year and the inicial Eczema Area and Severity Index (r = 0,78). There were no patients with methicillin resistant Staphylococcus aureus acquired in the community.

Conclusion: There is a relevant influence of staphylococcal colonization on the severity of atopic dermatitis and the number of appointments required by its exacerbation. Methicillin resistance among those affected by S. aureus does not seem to be an emergent problem, in this Brazilian sample.

Show MeSH
Related in: MedlinePlus