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Reduced cortical thickness in primary open-angle glaucoma and its relationship to the retinal nerve fiber layer thickness.

Yu L, Xie B, Yin X, Liang M, Evans AC, Wang J, Dai C - PLoS ONE (2013)

Bottom Line: POAG patients showed significant bilateral cortical thinning in the anterior half of the visual cortex around the calcarine sulci (left BA 17 and BA 18, right BA17) and in some smaller regions located in the left middle temporal gyrus (BA37) and fusiform gyrus (BA19).The thickness of the visual cortex correlated positively with RNFL thickness (left, r = 0.44, p = 0.01; right, r = 0.38, p = 0.03).Significant differences between mild and severe groups were observed with regard to both RNFL thickness and the thickness of bilateral visual cortex (p < 0.05).

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing, China ; Department of Radiology, 401st hospital of the People's Liberation Army, Qingdao, Shandong, China.

ABSTRACT

Objectives: To examine possible changes in cortical thickness and their relationship to retinal nerve fiber layer (RNFL) thickness in patients with primary open-angle glaucoma (POAG).

Materials and methods: Thirty-six patients with POAG and 40 matched healthy controls were enrolled in this study. All subjects underwent a comprehensive ophthalmologic examination and a high resolution structural magnetic resonance scan. Cortical thickness analysis was used to assess the changes between patients and controls. Correlations between the thickness of the visual cortex and RNFL thickness were also analyzed. Finally, the relationship between the severity of changes in the visual cortex and RNFL thickness was evaluated by comparing patients with mild and severe groups.

Results: POAG patients showed significant bilateral cortical thinning in the anterior half of the visual cortex around the calcarine sulci (left BA 17 and BA 18, right BA17) and in some smaller regions located in the left middle temporal gyrus (BA37) and fusiform gyrus (BA19). The thickness of the visual cortex correlated positively with RNFL thickness (left, r = 0.44, p = 0.01; right, r = 0.38, p = 0.03). Significant differences between mild and severe groups were observed with regard to both RNFL thickness and the thickness of bilateral visual cortex (p < 0.05).

Conclusion: Our findings indicate that cortical thickness analysis may be sufficiently sensitive to detect cortical alterations in POAG and that the measurement has great potential for clinical application.

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Related in: MedlinePlus

Cortical thinning in POAG patients compare to normal controls.Differences in cortical thickness are superimposed on a hemisphere-unbiased iterative surface template. Color represents the regions of cortical atrophy in patients with POAG.
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pone-0073208-g001: Cortical thinning in POAG patients compare to normal controls.Differences in cortical thickness are superimposed on a hemisphere-unbiased iterative surface template. Color represents the regions of cortical atrophy in patients with POAG.

Mentions: POAG patients showed significant bilateral cortical thinning in the anterior half of the visual cortex around the calcarine sulci (calcarine cortex) including the right BA 17 and left BA 17 and BA 18. Some smaller regions located in the left middle temporal gyrus (BA37) and the fusiform gyrus (BA19) also showed thinning relative to normal controls (p < 0.005, uncorrected; Figure 1, Table 2). No increase in cortical thickness relative to the controls was found in patients.


Reduced cortical thickness in primary open-angle glaucoma and its relationship to the retinal nerve fiber layer thickness.

Yu L, Xie B, Yin X, Liang M, Evans AC, Wang J, Dai C - PLoS ONE (2013)

Cortical thinning in POAG patients compare to normal controls.Differences in cortical thickness are superimposed on a hemisphere-unbiased iterative surface template. Color represents the regions of cortical atrophy in patients with POAG.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3760921&req=5

pone-0073208-g001: Cortical thinning in POAG patients compare to normal controls.Differences in cortical thickness are superimposed on a hemisphere-unbiased iterative surface template. Color represents the regions of cortical atrophy in patients with POAG.
Mentions: POAG patients showed significant bilateral cortical thinning in the anterior half of the visual cortex around the calcarine sulci (calcarine cortex) including the right BA 17 and left BA 17 and BA 18. Some smaller regions located in the left middle temporal gyrus (BA37) and the fusiform gyrus (BA19) also showed thinning relative to normal controls (p < 0.005, uncorrected; Figure 1, Table 2). No increase in cortical thickness relative to the controls was found in patients.

Bottom Line: POAG patients showed significant bilateral cortical thinning in the anterior half of the visual cortex around the calcarine sulci (left BA 17 and BA 18, right BA17) and in some smaller regions located in the left middle temporal gyrus (BA37) and fusiform gyrus (BA19).The thickness of the visual cortex correlated positively with RNFL thickness (left, r = 0.44, p = 0.01; right, r = 0.38, p = 0.03).Significant differences between mild and severe groups were observed with regard to both RNFL thickness and the thickness of bilateral visual cortex (p < 0.05).

View Article: PubMed Central - PubMed

Affiliation: Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing, China ; Department of Radiology, 401st hospital of the People's Liberation Army, Qingdao, Shandong, China.

ABSTRACT

Objectives: To examine possible changes in cortical thickness and their relationship to retinal nerve fiber layer (RNFL) thickness in patients with primary open-angle glaucoma (POAG).

Materials and methods: Thirty-six patients with POAG and 40 matched healthy controls were enrolled in this study. All subjects underwent a comprehensive ophthalmologic examination and a high resolution structural magnetic resonance scan. Cortical thickness analysis was used to assess the changes between patients and controls. Correlations between the thickness of the visual cortex and RNFL thickness were also analyzed. Finally, the relationship between the severity of changes in the visual cortex and RNFL thickness was evaluated by comparing patients with mild and severe groups.

Results: POAG patients showed significant bilateral cortical thinning in the anterior half of the visual cortex around the calcarine sulci (left BA 17 and BA 18, right BA17) and in some smaller regions located in the left middle temporal gyrus (BA37) and fusiform gyrus (BA19). The thickness of the visual cortex correlated positively with RNFL thickness (left, r = 0.44, p = 0.01; right, r = 0.38, p = 0.03). Significant differences between mild and severe groups were observed with regard to both RNFL thickness and the thickness of bilateral visual cortex (p < 0.05).

Conclusion: Our findings indicate that cortical thickness analysis may be sufficiently sensitive to detect cortical alterations in POAG and that the measurement has great potential for clinical application.

Show MeSH
Related in: MedlinePlus