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Tractography of the corpus callosum in Huntington's disease.

Phillips O, Sanchez-Castaneda C, Elifani F, Maglione V, Di Pardo A, Caltagirone C, Squitieri F, Sabatini U, Di Paola M - PLoS ONE (2013)

Bottom Line: Tractography results showed decreased fractional anisotropy (FA) and increased radial diffusivity (RD) across broad regions of the CC in Pre-HD subjects.These results add evidence that CC pathways are compromised prior to disease onset with possible demyelination occurring early in the disease and suggest that CAG repeat length is a contributing factor to connectivity deficits.Furthermore, disruption of these callosal pathways potentially contributes to the disturbances of motor and cognitive processing that characterize HD.

View Article: PubMed Central - PubMed

Affiliation: Clinical and Behavioural Neurology Department, Istituto di Ricovero e Cura a Carattere Scientifico Santa Lucia Foundation, Rome, Italy.

ABSTRACT
White matter abnormalities have been shown in presymptomatic and symptomatic Huntington's disease (HD) subjects using Magnetic Resonance Imaging (MRI) and Diffusion Tensor Imaging (DTI) methods. The largest white matter tract, the corpus callosum (CC), has been shown to be particularly vulnerable; however, little work has been done to investigate the regional specificity of tract abnormalities in the CC. Thus, this study examined the major callosal tracts by applying DTI-based tractography. Using TrackVis, a previously defined region of interest tractography method parcellating CC into seven major tracts based on target region was applied to 30 direction DTI data collected from 100 subjects: presymptomatic HD (Pre-HD) subjects (n=25), HD patients (n=25) and healthy control subjects (n=50). Tractography results showed decreased fractional anisotropy (FA) and increased radial diffusivity (RD) across broad regions of the CC in Pre-HD subjects. Similar though more severe deficits were seen in HD patients. In Pre-HD and HD, callosal FA and RD were correlated with Disease Burden/CAG repeat length as well as motor (UHDRSI) and cognitive (URDRS2) assessments. These results add evidence that CC pathways are compromised prior to disease onset with possible demyelination occurring early in the disease and suggest that CAG repeat length is a contributing factor to connectivity deficits. Furthermore, disruption of these callosal pathways potentially contributes to the disturbances of motor and cognitive processing that characterize HD.

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Related in: MedlinePlus

Corpus Callosum Tract Measures by Diagnosis.Bar graphs show differences between CC FA, AD, and RD for the whole CC and the seven components of the CC as defined by the tract target region. The error bars represent the Standard Error Mean (SEM). Tracts: Whole corpus callosum (CC); orbital frontal (OF), anterior frontal (AF), superior frontal (SF), superior parietal (SP), posterior parietal (PP), temporal (Temp), and occipital (Occ).
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pone-0073280-g001: Corpus Callosum Tract Measures by Diagnosis.Bar graphs show differences between CC FA, AD, and RD for the whole CC and the seven components of the CC as defined by the tract target region. The error bars represent the Standard Error Mean (SEM). Tracts: Whole corpus callosum (CC); orbital frontal (OF), anterior frontal (AF), superior frontal (SF), superior parietal (SP), posterior parietal (PP), temporal (Temp), and occipital (Occ).

Mentions: Statistical details for Manova analysis are provided in Table 2. Track measures are outlined in Table S2. Figure 1 further provides a graphical overview of the findings as well as an indication of significant results.


Tractography of the corpus callosum in Huntington's disease.

Phillips O, Sanchez-Castaneda C, Elifani F, Maglione V, Di Pardo A, Caltagirone C, Squitieri F, Sabatini U, Di Paola M - PLoS ONE (2013)

Corpus Callosum Tract Measures by Diagnosis.Bar graphs show differences between CC FA, AD, and RD for the whole CC and the seven components of the CC as defined by the tract target region. The error bars represent the Standard Error Mean (SEM). Tracts: Whole corpus callosum (CC); orbital frontal (OF), anterior frontal (AF), superior frontal (SF), superior parietal (SP), posterior parietal (PP), temporal (Temp), and occipital (Occ).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3760905&req=5

pone-0073280-g001: Corpus Callosum Tract Measures by Diagnosis.Bar graphs show differences between CC FA, AD, and RD for the whole CC and the seven components of the CC as defined by the tract target region. The error bars represent the Standard Error Mean (SEM). Tracts: Whole corpus callosum (CC); orbital frontal (OF), anterior frontal (AF), superior frontal (SF), superior parietal (SP), posterior parietal (PP), temporal (Temp), and occipital (Occ).
Mentions: Statistical details for Manova analysis are provided in Table 2. Track measures are outlined in Table S2. Figure 1 further provides a graphical overview of the findings as well as an indication of significant results.

Bottom Line: Tractography results showed decreased fractional anisotropy (FA) and increased radial diffusivity (RD) across broad regions of the CC in Pre-HD subjects.These results add evidence that CC pathways are compromised prior to disease onset with possible demyelination occurring early in the disease and suggest that CAG repeat length is a contributing factor to connectivity deficits.Furthermore, disruption of these callosal pathways potentially contributes to the disturbances of motor and cognitive processing that characterize HD.

View Article: PubMed Central - PubMed

Affiliation: Clinical and Behavioural Neurology Department, Istituto di Ricovero e Cura a Carattere Scientifico Santa Lucia Foundation, Rome, Italy.

ABSTRACT
White matter abnormalities have been shown in presymptomatic and symptomatic Huntington's disease (HD) subjects using Magnetic Resonance Imaging (MRI) and Diffusion Tensor Imaging (DTI) methods. The largest white matter tract, the corpus callosum (CC), has been shown to be particularly vulnerable; however, little work has been done to investigate the regional specificity of tract abnormalities in the CC. Thus, this study examined the major callosal tracts by applying DTI-based tractography. Using TrackVis, a previously defined region of interest tractography method parcellating CC into seven major tracts based on target region was applied to 30 direction DTI data collected from 100 subjects: presymptomatic HD (Pre-HD) subjects (n=25), HD patients (n=25) and healthy control subjects (n=50). Tractography results showed decreased fractional anisotropy (FA) and increased radial diffusivity (RD) across broad regions of the CC in Pre-HD subjects. Similar though more severe deficits were seen in HD patients. In Pre-HD and HD, callosal FA and RD were correlated with Disease Burden/CAG repeat length as well as motor (UHDRSI) and cognitive (URDRS2) assessments. These results add evidence that CC pathways are compromised prior to disease onset with possible demyelination occurring early in the disease and suggest that CAG repeat length is a contributing factor to connectivity deficits. Furthermore, disruption of these callosal pathways potentially contributes to the disturbances of motor and cognitive processing that characterize HD.

Show MeSH
Related in: MedlinePlus