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Low openness on the revised NEO personality inventory as a risk factor for treatment-resistant depression.

Takahashi M, Shirayama Y, Muneoka K, Suzuki M, Sato K, Hashimoto K - PLoS ONE (2013)

Bottom Line: Here, we analyzed additional psychological traits in these patients.However, patients in remitted depression showed no significant scores on NEO.Many studies have reported that depressed patients show high neuroticism, low extraversion and low conscientiousness on the NEO.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, Teikyo University Chiba Medical Center, Ichihara, Japan ; Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan.

ABSTRACT

Background: Recently, we reported that low reward dependence, and to a lesser extent, low cooperativeness in the Temperature and Character Inventory (TCI) may be risk factors for treatment-resistant depression. Here, we analyzed additional psychological traits in these patients.

Methods: We administered Costa and McCrae's five-factor model personality inventory, NEO Personality Inventory-Revised (NEO-PI-R), to antidepressant-treatment resistant depressed patients (n=35), remitted depressed patients (n=27), and healthy controls (n=66). We also evaluated the relationships between scores on NEO and TCI, using the same cohort of patients with treatment-resistant depression, as our previous study.

Results: Patients with treatment-resistant depression showed high scores for neuroticism, low scores for extraversion, openness and conscientiousness, without changes in agreeableness, on the NEO. However, patients in remitted depression showed no significant scores on NEO. Patients with treatment-resistant depression and low openness on NEO showed positive relationships with reward dependence and cooperativeness on the TCI.

Conclusions: Many studies have reported that depressed patients show high neuroticism, low extraversion and low conscientiousness on the NEO. Our study highlights low openness on the NEO, as a risk mediator in treatment-resistant depression. This newly identified trait should be included as a risk factor in treatment-resistant depression.

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Related in: MedlinePlus

Analysis of variance shows a significant difference between three groups for (A) Neuroticism (F (2,125) = 11.10; P<0.001), (B) Extraversion (F (2,125) = 26.42; P<0.001), (C) Openness (F (2,125) = 5.93; P = 0.004), and (E) Conscientiousness (F (2,125) = 4.88; P = 0.009).In (D) Agreeableness, there is not a significant difference between three groups (F (2,125) = 0.49; P = 0.616). *P<0.01, **P<0.001 compared to control (ANOVA followed by Scheffe test).
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pone-0071964-g001: Analysis of variance shows a significant difference between three groups for (A) Neuroticism (F (2,125) = 11.10; P<0.001), (B) Extraversion (F (2,125) = 26.42; P<0.001), (C) Openness (F (2,125) = 5.93; P = 0.004), and (E) Conscientiousness (F (2,125) = 4.88; P = 0.009).In (D) Agreeableness, there is not a significant difference between three groups (F (2,125) = 0.49; P = 0.616). *P<0.01, **P<0.001 compared to control (ANOVA followed by Scheffe test).

Mentions: MANOVA indicated a significant group effect (F = 5.777, P<0.0001). Subsequent one-way ANOVA demonstrated that patients with treatment-resistant depression showed significantly high scores for neuroticism and lower scores for extraversion, openness and conscientiousness on the NEO, compared with healthy controls or patients with remitted depression (Figure 1). Patients in remission showed no significant differences in NEO scores, compared to healthy controls (Figure 1).


Low openness on the revised NEO personality inventory as a risk factor for treatment-resistant depression.

Takahashi M, Shirayama Y, Muneoka K, Suzuki M, Sato K, Hashimoto K - PLoS ONE (2013)

Analysis of variance shows a significant difference between three groups for (A) Neuroticism (F (2,125) = 11.10; P<0.001), (B) Extraversion (F (2,125) = 26.42; P<0.001), (C) Openness (F (2,125) = 5.93; P = 0.004), and (E) Conscientiousness (F (2,125) = 4.88; P = 0.009).In (D) Agreeableness, there is not a significant difference between three groups (F (2,125) = 0.49; P = 0.616). *P<0.01, **P<0.001 compared to control (ANOVA followed by Scheffe test).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3760870&req=5

pone-0071964-g001: Analysis of variance shows a significant difference between three groups for (A) Neuroticism (F (2,125) = 11.10; P<0.001), (B) Extraversion (F (2,125) = 26.42; P<0.001), (C) Openness (F (2,125) = 5.93; P = 0.004), and (E) Conscientiousness (F (2,125) = 4.88; P = 0.009).In (D) Agreeableness, there is not a significant difference between three groups (F (2,125) = 0.49; P = 0.616). *P<0.01, **P<0.001 compared to control (ANOVA followed by Scheffe test).
Mentions: MANOVA indicated a significant group effect (F = 5.777, P<0.0001). Subsequent one-way ANOVA demonstrated that patients with treatment-resistant depression showed significantly high scores for neuroticism and lower scores for extraversion, openness and conscientiousness on the NEO, compared with healthy controls or patients with remitted depression (Figure 1). Patients in remission showed no significant differences in NEO scores, compared to healthy controls (Figure 1).

Bottom Line: Here, we analyzed additional psychological traits in these patients.However, patients in remitted depression showed no significant scores on NEO.Many studies have reported that depressed patients show high neuroticism, low extraversion and low conscientiousness on the NEO.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry, Teikyo University Chiba Medical Center, Ichihara, Japan ; Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan.

ABSTRACT

Background: Recently, we reported that low reward dependence, and to a lesser extent, low cooperativeness in the Temperature and Character Inventory (TCI) may be risk factors for treatment-resistant depression. Here, we analyzed additional psychological traits in these patients.

Methods: We administered Costa and McCrae's five-factor model personality inventory, NEO Personality Inventory-Revised (NEO-PI-R), to antidepressant-treatment resistant depressed patients (n=35), remitted depressed patients (n=27), and healthy controls (n=66). We also evaluated the relationships between scores on NEO and TCI, using the same cohort of patients with treatment-resistant depression, as our previous study.

Results: Patients with treatment-resistant depression showed high scores for neuroticism, low scores for extraversion, openness and conscientiousness, without changes in agreeableness, on the NEO. However, patients in remitted depression showed no significant scores on NEO. Patients with treatment-resistant depression and low openness on NEO showed positive relationships with reward dependence and cooperativeness on the TCI.

Conclusions: Many studies have reported that depressed patients show high neuroticism, low extraversion and low conscientiousness on the NEO. Our study highlights low openness on the NEO, as a risk mediator in treatment-resistant depression. This newly identified trait should be included as a risk factor in treatment-resistant depression.

Show MeSH
Related in: MedlinePlus