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Review of histopathological and molecular prognostic features in colorectal cancer.

Marzouk O, Schofield J - Cancers (Basel) (2011)

Bottom Line: Histopathological factors remain paramount in this respect.Likewise the prognostic significance of resection margins, particularly circumferential margins has been appreciated in the last two decades.A number of molecular and genetic markers such as KRAS, BRAF and microsatellite instability are also important and correlate with histological features in some patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Cellular Pathology, Maidstone Hospital, Hermitage Lane, Maidstone, Kent ME16 9QQ, UK. john.schofield@nhs.net.

ABSTRACT
Prediction of prognosis in colorectal cancer is vital for the choice of therapeutic options. Histopathological factors remain paramount in this respect. Factors such as tumor size, histological type and subtype, presence of signet ring morphology and the degree of differentiation as well as the presence of lymphovascular invasion and lymph node involvement are well known factors that influence outcome. Our understanding of these factors has improved in the past few years with factors such as tumor budding, lymphocytic infiltration being recognized as important. Likewise the prognostic significance of resection margins, particularly circumferential margins has been appreciated in the last two decades. A number of molecular and genetic markers such as KRAS, BRAF and microsatellite instability are also important and correlate with histological features in some patients. This review summarizes our current understanding of the main histopathological factors that affect prognosis of colorectal cancer.

No MeSH data available.


Related in: MedlinePlus

The Jass Classification (Ueno et al., 2004 [17]): not in order Tumor is scored in three areas; extramural spread, positive nodes and tumor budding. The total score place it in a prognostic group.
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f1-cancers-03-02767: The Jass Classification (Ueno et al., 2004 [17]): not in order Tumor is scored in three areas; extramural spread, positive nodes and tumor budding. The total score place it in a prognostic group.

Mentions: Jass and colleagues [15,16] attempted to devise and validate a better prognostic system, adding the invasive front of the tumor as a prognostic biologic factor. This was subsequently modified [17] and simplified (Figure 1). They proposed using three variables only; presence of extramural spread, presence of positive nodes and extent of histologic tumor budding. They believed that their classification would forecast prognosis more accurately and would be a better guide to adjuvant therapy. Despite being validated [17], the system was a radical departure from the Dukes/TNM line, suffered from weak interobserver reproducibility and consequently has not been widely adopted [18].


Review of histopathological and molecular prognostic features in colorectal cancer.

Marzouk O, Schofield J - Cancers (Basel) (2011)

The Jass Classification (Ueno et al., 2004 [17]): not in order Tumor is scored in three areas; extramural spread, positive nodes and tumor budding. The total score place it in a prognostic group.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3757442&req=5

f1-cancers-03-02767: The Jass Classification (Ueno et al., 2004 [17]): not in order Tumor is scored in three areas; extramural spread, positive nodes and tumor budding. The total score place it in a prognostic group.
Mentions: Jass and colleagues [15,16] attempted to devise and validate a better prognostic system, adding the invasive front of the tumor as a prognostic biologic factor. This was subsequently modified [17] and simplified (Figure 1). They proposed using three variables only; presence of extramural spread, presence of positive nodes and extent of histologic tumor budding. They believed that their classification would forecast prognosis more accurately and would be a better guide to adjuvant therapy. Despite being validated [17], the system was a radical departure from the Dukes/TNM line, suffered from weak interobserver reproducibility and consequently has not been widely adopted [18].

Bottom Line: Histopathological factors remain paramount in this respect.Likewise the prognostic significance of resection margins, particularly circumferential margins has been appreciated in the last two decades.A number of molecular and genetic markers such as KRAS, BRAF and microsatellite instability are also important and correlate with histological features in some patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Cellular Pathology, Maidstone Hospital, Hermitage Lane, Maidstone, Kent ME16 9QQ, UK. john.schofield@nhs.net.

ABSTRACT
Prediction of prognosis in colorectal cancer is vital for the choice of therapeutic options. Histopathological factors remain paramount in this respect. Factors such as tumor size, histological type and subtype, presence of signet ring morphology and the degree of differentiation as well as the presence of lymphovascular invasion and lymph node involvement are well known factors that influence outcome. Our understanding of these factors has improved in the past few years with factors such as tumor budding, lymphocytic infiltration being recognized as important. Likewise the prognostic significance of resection margins, particularly circumferential margins has been appreciated in the last two decades. A number of molecular and genetic markers such as KRAS, BRAF and microsatellite instability are also important and correlate with histological features in some patients. This review summarizes our current understanding of the main histopathological factors that affect prognosis of colorectal cancer.

No MeSH data available.


Related in: MedlinePlus