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Enhancing photodynamyc therapy efficacy by combination therapy: dated, current and oncoming strategies.

Postiglione I, Chiaviello A, Palumbo G - Cancers (Basel) (2011)

Bottom Line: Reports cited in this work have been selected because considered representative.Some paragraphs are dedicated to PDT and immuno-modulation, others to associations of PDT with angiogenesis inhibitors, receptor inhibitors, radiotherapy and more.Finally, a look is dedicated to combinations involving the use of natural compounds and, as new entries, drugs that act as proteasome inhibitors.

View Article: PubMed Central - PubMed

Affiliation: Department of Molecular and Cellular Biology and Pathology "L. Califano", University Federico II, Via S. Pansini, Naples 5 80131, Italy. palumbo@unina.it.

ABSTRACT
Combination therapy is a common practice in many medical disciplines. It is defined as the use of more than one drug to treat the same disease. Sometimes this expression describes the simultaneous use of therapeutic approaches that target different cellular/molecular pathways, increasing the chances of killing the diseased cell. This short review is concerned with therapeutic combinations in which PDT (Photodynamyc Therapy) is the core therapeutic partner. Besides the description of the principal methods used to assess the efficacy attained by combinations in respect to monotherapy, this review describes experimental results in which PDT was combined with conventional drugs in different experimental conditions. This inventory is far from exhaustive, as the number of photosensitizers used in combination with different drugs is very large. Reports cited in this work have been selected because considered representative. The combinations we have reviewed include the association of PDT with anti-oxidants, chemotherapeutics, drugs targeting topoisomerases I and II, antimetabolites and others. Some paragraphs are dedicated to PDT and immuno-modulation, others to associations of PDT with angiogenesis inhibitors, receptor inhibitors, radiotherapy and more. Finally, a look is dedicated to combinations involving the use of natural compounds and, as new entries, drugs that act as proteasome inhibitors.

No MeSH data available.


Related in: MedlinePlus

Over-simplified picture of light distribution and cellular responses during PDT.
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Related In: Results  -  Collection

License
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f1-cancers-03-02597: Over-simplified picture of light distribution and cellular responses during PDT.

Mentions: The topically or systemically administered photosensitizers accumulate preferentially within cancerous tissues, but the selective concentration within the cancerous cells is only ideal. In fact, several factors such as the extent of vascularization, the type of photosensitizer and others, affect this unbalanced distribution. Photosensitizers are activated by exposure to light (Figure 1).


Enhancing photodynamyc therapy efficacy by combination therapy: dated, current and oncoming strategies.

Postiglione I, Chiaviello A, Palumbo G - Cancers (Basel) (2011)

Over-simplified picture of light distribution and cellular responses during PDT.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3757433&req=5

f1-cancers-03-02597: Over-simplified picture of light distribution and cellular responses during PDT.
Mentions: The topically or systemically administered photosensitizers accumulate preferentially within cancerous tissues, but the selective concentration within the cancerous cells is only ideal. In fact, several factors such as the extent of vascularization, the type of photosensitizer and others, affect this unbalanced distribution. Photosensitizers are activated by exposure to light (Figure 1).

Bottom Line: Reports cited in this work have been selected because considered representative.Some paragraphs are dedicated to PDT and immuno-modulation, others to associations of PDT with angiogenesis inhibitors, receptor inhibitors, radiotherapy and more.Finally, a look is dedicated to combinations involving the use of natural compounds and, as new entries, drugs that act as proteasome inhibitors.

View Article: PubMed Central - PubMed

Affiliation: Department of Molecular and Cellular Biology and Pathology "L. Califano", University Federico II, Via S. Pansini, Naples 5 80131, Italy. palumbo@unina.it.

ABSTRACT
Combination therapy is a common practice in many medical disciplines. It is defined as the use of more than one drug to treat the same disease. Sometimes this expression describes the simultaneous use of therapeutic approaches that target different cellular/molecular pathways, increasing the chances of killing the diseased cell. This short review is concerned with therapeutic combinations in which PDT (Photodynamyc Therapy) is the core therapeutic partner. Besides the description of the principal methods used to assess the efficacy attained by combinations in respect to monotherapy, this review describes experimental results in which PDT was combined with conventional drugs in different experimental conditions. This inventory is far from exhaustive, as the number of photosensitizers used in combination with different drugs is very large. Reports cited in this work have been selected because considered representative. The combinations we have reviewed include the association of PDT with anti-oxidants, chemotherapeutics, drugs targeting topoisomerases I and II, antimetabolites and others. Some paragraphs are dedicated to PDT and immuno-modulation, others to associations of PDT with angiogenesis inhibitors, receptor inhibitors, radiotherapy and more. Finally, a look is dedicated to combinations involving the use of natural compounds and, as new entries, drugs that act as proteasome inhibitors.

No MeSH data available.


Related in: MedlinePlus