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Contrast-Enhanced Ultrasound (CEUS) for Echographic Detection of Hepato Cellular Carcinoma in Cirrhotic Patients Previously Treated with Multiple Techniques: Comparison of Conventional US, Spiral CT and 3-Dimensional CEUS with Navigator Technique (3DNav CEUS).

Giangregorio F - Cancers (Basel) (2011)

Bottom Line: A commercially available technique named "NAVIGATOR" (Esaote, Italy) easily enables a 3-D reconstruction of a single 2-D acquisition of Contrast Enhanced Ultrasound (CEUS) imaging of the whole liver (with a volumetric correction thanks to the electromagnetic device of NAVIGATOR).Sens.,Spec.,diagn.-Acc.,PPV and NPV were evaluated; comparison and differences between the techniques were obtained with chi-square (SPSS release-15).This technique, in particular, showed the presence of lesions even in the cases not detected with spiral CT.

View Article: PubMed Central - PubMed

Affiliation: Department of Gastroenterology, Guglielmo da Saliceto Hospital, Via Taverna 49, Piacenza 29121, Italy. f.giangregorio@alice.it.

ABSTRACT
A commercially available technique named "NAVIGATOR" (Esaote, Italy) easily enables a 3-D reconstruction of a single 2-D acquisition of Contrast Enhanced Ultrasound (CEUS) imaging of the whole liver (with a volumetric correction thanks to the electromagnetic device of NAVIGATOR). Aim of the study was to evaluate this "panoramic" technique in comparison with conventional US and spiral CT in the detection of new hepatic lesions. 144 cirrhotic patients (previously treated for hepato cellular carcinoma (HCC)) in follow-up with detection of 98 new nodules (N), 28 multinodular (Nmulti), 14 loco-regional regrowth (LR) 94 efficaciously treated without new nodules (neg) and four multinodular without new nodules, were submitted to 200 examinations with this new technique from November 2008 to November 2009. 3DNavCEUS was performed using SonoVue (Bracco), as contrast agent, and a machine (Technos MPX, Esaote). Spiral CT and 3DNav CEUS were performed in the same month during follow up. Sens.,Spec.,diagn.-Acc.,PPV and NPV were evaluated; comparison and differences between the techniques were obtained with chi-square (SPSS release-15). Final diagnosis was: 98 new lesions (N) (one to three), 28 multinodular HCC (Nmulti) and 14 loco-regional regrowth (LR); in 94 no more lesions were observed during follow-up; conventional US obtained: 58 N (+18 multinodularN and 8 LR), 40 false negative (+10 Nmulti and 6 LR) (sens:59.2, spec:100%, Diagn Accur:73.6, PPV:100; NPV:70.1); spiral CT obtained: 84N (+26-multinodularN and 14-LR), 14 false-negative (+2-Nmulti), and one false-positive (sens:85.7, spec:97.9%, Diagn Accur:90.9, PPV:97.7; NPV:86.8); 3DNAV obtained: 92N (+28 multinodularN and 14LR), 6 false-negative, and two false-positives (sens:93.9, spec:97.9%, Diagn Accur:95.6, PPV:97.9; NPV:93.9). 3-DNav CEUS is significantly better than US and almost similar to spiral CT for detection of new HCC. This technique, in particular, showed the presence of lesions even in the cases not detected with spiral CT.

No MeSH data available.


Related in: MedlinePlus

3-D NAV CEUS reconstruction with parenchymal rendered volume: Two new HCC in different liver segments are evident. This kind of reconstruction is able to show HCC nodules inside liver parenchyma; this is performed offline with the software (inside TECHNOS MPX) specific for 3-D rendering.
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f5-cancers-03-01763: 3-D NAV CEUS reconstruction with parenchymal rendered volume: Two new HCC in different liver segments are evident. This kind of reconstruction is able to show HCC nodules inside liver parenchyma; this is performed offline with the software (inside TECHNOS MPX) specific for 3-D rendering.

Mentions: To easily perform a 3-D reconstruction of a 2-D acquisition of CEUS imaging of the whole liver, the 2-D acquisition is performed with real time scanning perpendicularly on the long-axis of the liver, for a complete 2-D image of its short-axis (Figure 2). The subsequent reconstructions of these planes show a rendered volume with a “parenchimal” aspect (Figure 5) or with a “vascular” map (Figure 6) of all the hepatic segments with an acquisition in the early arterial and in portal phase.


Contrast-Enhanced Ultrasound (CEUS) for Echographic Detection of Hepato Cellular Carcinoma in Cirrhotic Patients Previously Treated with Multiple Techniques: Comparison of Conventional US, Spiral CT and 3-Dimensional CEUS with Navigator Technique (3DNav CEUS).

Giangregorio F - Cancers (Basel) (2011)

3-D NAV CEUS reconstruction with parenchymal rendered volume: Two new HCC in different liver segments are evident. This kind of reconstruction is able to show HCC nodules inside liver parenchyma; this is performed offline with the software (inside TECHNOS MPX) specific for 3-D rendering.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3757389&req=5

f5-cancers-03-01763: 3-D NAV CEUS reconstruction with parenchymal rendered volume: Two new HCC in different liver segments are evident. This kind of reconstruction is able to show HCC nodules inside liver parenchyma; this is performed offline with the software (inside TECHNOS MPX) specific for 3-D rendering.
Mentions: To easily perform a 3-D reconstruction of a 2-D acquisition of CEUS imaging of the whole liver, the 2-D acquisition is performed with real time scanning perpendicularly on the long-axis of the liver, for a complete 2-D image of its short-axis (Figure 2). The subsequent reconstructions of these planes show a rendered volume with a “parenchimal” aspect (Figure 5) or with a “vascular” map (Figure 6) of all the hepatic segments with an acquisition in the early arterial and in portal phase.

Bottom Line: A commercially available technique named "NAVIGATOR" (Esaote, Italy) easily enables a 3-D reconstruction of a single 2-D acquisition of Contrast Enhanced Ultrasound (CEUS) imaging of the whole liver (with a volumetric correction thanks to the electromagnetic device of NAVIGATOR).Sens.,Spec.,diagn.-Acc.,PPV and NPV were evaluated; comparison and differences between the techniques were obtained with chi-square (SPSS release-15).This technique, in particular, showed the presence of lesions even in the cases not detected with spiral CT.

View Article: PubMed Central - PubMed

Affiliation: Department of Gastroenterology, Guglielmo da Saliceto Hospital, Via Taverna 49, Piacenza 29121, Italy. f.giangregorio@alice.it.

ABSTRACT
A commercially available technique named "NAVIGATOR" (Esaote, Italy) easily enables a 3-D reconstruction of a single 2-D acquisition of Contrast Enhanced Ultrasound (CEUS) imaging of the whole liver (with a volumetric correction thanks to the electromagnetic device of NAVIGATOR). Aim of the study was to evaluate this "panoramic" technique in comparison with conventional US and spiral CT in the detection of new hepatic lesions. 144 cirrhotic patients (previously treated for hepato cellular carcinoma (HCC)) in follow-up with detection of 98 new nodules (N), 28 multinodular (Nmulti), 14 loco-regional regrowth (LR) 94 efficaciously treated without new nodules (neg) and four multinodular without new nodules, were submitted to 200 examinations with this new technique from November 2008 to November 2009. 3DNavCEUS was performed using SonoVue (Bracco), as contrast agent, and a machine (Technos MPX, Esaote). Spiral CT and 3DNav CEUS were performed in the same month during follow up. Sens.,Spec.,diagn.-Acc.,PPV and NPV were evaluated; comparison and differences between the techniques were obtained with chi-square (SPSS release-15). Final diagnosis was: 98 new lesions (N) (one to three), 28 multinodular HCC (Nmulti) and 14 loco-regional regrowth (LR); in 94 no more lesions were observed during follow-up; conventional US obtained: 58 N (+18 multinodularN and 8 LR), 40 false negative (+10 Nmulti and 6 LR) (sens:59.2, spec:100%, Diagn Accur:73.6, PPV:100; NPV:70.1); spiral CT obtained: 84N (+26-multinodularN and 14-LR), 14 false-negative (+2-Nmulti), and one false-positive (sens:85.7, spec:97.9%, Diagn Accur:90.9, PPV:97.7; NPV:86.8); 3DNAV obtained: 92N (+28 multinodularN and 14LR), 6 false-negative, and two false-positives (sens:93.9, spec:97.9%, Diagn Accur:95.6, PPV:97.9; NPV:93.9). 3-DNav CEUS is significantly better than US and almost similar to spiral CT for detection of new HCC. This technique, in particular, showed the presence of lesions even in the cases not detected with spiral CT.

No MeSH data available.


Related in: MedlinePlus