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Contrast-Enhanced Ultrasound (CEUS) for Echographic Detection of Hepato Cellular Carcinoma in Cirrhotic Patients Previously Treated with Multiple Techniques: Comparison of Conventional US, Spiral CT and 3-Dimensional CEUS with Navigator Technique (3DNav CEUS).

Giangregorio F - Cancers (Basel) (2011)

Bottom Line: A commercially available technique named "NAVIGATOR" (Esaote, Italy) easily enables a 3-D reconstruction of a single 2-D acquisition of Contrast Enhanced Ultrasound (CEUS) imaging of the whole liver (with a volumetric correction thanks to the electromagnetic device of NAVIGATOR).Sens.,Spec.,diagn.-Acc.,PPV and NPV were evaluated; comparison and differences between the techniques were obtained with chi-square (SPSS release-15).This technique, in particular, showed the presence of lesions even in the cases not detected with spiral CT.

View Article: PubMed Central - PubMed

Affiliation: Department of Gastroenterology, Guglielmo da Saliceto Hospital, Via Taverna 49, Piacenza 29121, Italy. f.giangregorio@alice.it.

ABSTRACT
A commercially available technique named "NAVIGATOR" (Esaote, Italy) easily enables a 3-D reconstruction of a single 2-D acquisition of Contrast Enhanced Ultrasound (CEUS) imaging of the whole liver (with a volumetric correction thanks to the electromagnetic device of NAVIGATOR). Aim of the study was to evaluate this "panoramic" technique in comparison with conventional US and spiral CT in the detection of new hepatic lesions. 144 cirrhotic patients (previously treated for hepato cellular carcinoma (HCC)) in follow-up with detection of 98 new nodules (N), 28 multinodular (Nmulti), 14 loco-regional regrowth (LR) 94 efficaciously treated without new nodules (neg) and four multinodular without new nodules, were submitted to 200 examinations with this new technique from November 2008 to November 2009. 3DNavCEUS was performed using SonoVue (Bracco), as contrast agent, and a machine (Technos MPX, Esaote). Spiral CT and 3DNav CEUS were performed in the same month during follow up. Sens.,Spec.,diagn.-Acc.,PPV and NPV were evaluated; comparison and differences between the techniques were obtained with chi-square (SPSS release-15). Final diagnosis was: 98 new lesions (N) (one to three), 28 multinodular HCC (Nmulti) and 14 loco-regional regrowth (LR); in 94 no more lesions were observed during follow-up; conventional US obtained: 58 N (+18 multinodularN and 8 LR), 40 false negative (+10 Nmulti and 6 LR) (sens:59.2, spec:100%, Diagn Accur:73.6, PPV:100; NPV:70.1); spiral CT obtained: 84N (+26-multinodularN and 14-LR), 14 false-negative (+2-Nmulti), and one false-positive (sens:85.7, spec:97.9%, Diagn Accur:90.9, PPV:97.7; NPV:86.8); 3DNAV obtained: 92N (+28 multinodularN and 14LR), 6 false-negative, and two false-positives (sens:93.9, spec:97.9%, Diagn Accur:95.6, PPV:97.9; NPV:93.9). 3-DNav CEUS is significantly better than US and almost similar to spiral CT for detection of new HCC. This technique, in particular, showed the presence of lesions even in the cases not detected with spiral CT.

No MeSH data available.


Related in: MedlinePlus

Draft of 3-D reconstruction: LEFT: Bidimensional continuous scanning of the liver evaluating its short axis through its long axis; the planes captured along the liver are rendered in a 3-dimensional reconstruction using software within the Navigator System.
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f2-cancers-03-01763: Draft of 3-D reconstruction: LEFT: Bidimensional continuous scanning of the liver evaluating its short axis through its long axis; the planes captured along the liver are rendered in a 3-dimensional reconstruction using software within the Navigator System.

Mentions: Navigator (Figure 1) is composed of a computer with a touch screen monitor, Tracking system type PCIBirds (Ascension technology-Degrees of freedom: Six (position and orientation); Translation range, any direction: Standard transmitter 0–30 (76.2 cm); Angular range: All attitude; Static accuracy standard sensor: 0.040 (1.0 mm) RMS position 0.15 degree RMS orientation). The navigation system is coupled with a US machine (Technos MPX; Esaote, Genoa, Italy). PCI bird is formed by an active sensor, united to the US probe, and a passive sensor, near to the patient. The active sensor transmits its spatial position and movements in comparison to the passive one; the probe movements are registered and the 3-D software inside Navigator system is able to correct the static 3-D reconstruction with the US scanning in comparison to probe movements. The final result is an accurate spatial reconstruction of the volume independent of the type of 2-D acquisition (Figure 2).


Contrast-Enhanced Ultrasound (CEUS) for Echographic Detection of Hepato Cellular Carcinoma in Cirrhotic Patients Previously Treated with Multiple Techniques: Comparison of Conventional US, Spiral CT and 3-Dimensional CEUS with Navigator Technique (3DNav CEUS).

Giangregorio F - Cancers (Basel) (2011)

Draft of 3-D reconstruction: LEFT: Bidimensional continuous scanning of the liver evaluating its short axis through its long axis; the planes captured along the liver are rendered in a 3-dimensional reconstruction using software within the Navigator System.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3757389&req=5

f2-cancers-03-01763: Draft of 3-D reconstruction: LEFT: Bidimensional continuous scanning of the liver evaluating its short axis through its long axis; the planes captured along the liver are rendered in a 3-dimensional reconstruction using software within the Navigator System.
Mentions: Navigator (Figure 1) is composed of a computer with a touch screen monitor, Tracking system type PCIBirds (Ascension technology-Degrees of freedom: Six (position and orientation); Translation range, any direction: Standard transmitter 0–30 (76.2 cm); Angular range: All attitude; Static accuracy standard sensor: 0.040 (1.0 mm) RMS position 0.15 degree RMS orientation). The navigation system is coupled with a US machine (Technos MPX; Esaote, Genoa, Italy). PCI bird is formed by an active sensor, united to the US probe, and a passive sensor, near to the patient. The active sensor transmits its spatial position and movements in comparison to the passive one; the probe movements are registered and the 3-D software inside Navigator system is able to correct the static 3-D reconstruction with the US scanning in comparison to probe movements. The final result is an accurate spatial reconstruction of the volume independent of the type of 2-D acquisition (Figure 2).

Bottom Line: A commercially available technique named "NAVIGATOR" (Esaote, Italy) easily enables a 3-D reconstruction of a single 2-D acquisition of Contrast Enhanced Ultrasound (CEUS) imaging of the whole liver (with a volumetric correction thanks to the electromagnetic device of NAVIGATOR).Sens.,Spec.,diagn.-Acc.,PPV and NPV were evaluated; comparison and differences between the techniques were obtained with chi-square (SPSS release-15).This technique, in particular, showed the presence of lesions even in the cases not detected with spiral CT.

View Article: PubMed Central - PubMed

Affiliation: Department of Gastroenterology, Guglielmo da Saliceto Hospital, Via Taverna 49, Piacenza 29121, Italy. f.giangregorio@alice.it.

ABSTRACT
A commercially available technique named "NAVIGATOR" (Esaote, Italy) easily enables a 3-D reconstruction of a single 2-D acquisition of Contrast Enhanced Ultrasound (CEUS) imaging of the whole liver (with a volumetric correction thanks to the electromagnetic device of NAVIGATOR). Aim of the study was to evaluate this "panoramic" technique in comparison with conventional US and spiral CT in the detection of new hepatic lesions. 144 cirrhotic patients (previously treated for hepato cellular carcinoma (HCC)) in follow-up with detection of 98 new nodules (N), 28 multinodular (Nmulti), 14 loco-regional regrowth (LR) 94 efficaciously treated without new nodules (neg) and four multinodular without new nodules, were submitted to 200 examinations with this new technique from November 2008 to November 2009. 3DNavCEUS was performed using SonoVue (Bracco), as contrast agent, and a machine (Technos MPX, Esaote). Spiral CT and 3DNav CEUS were performed in the same month during follow up. Sens.,Spec.,diagn.-Acc.,PPV and NPV were evaluated; comparison and differences between the techniques were obtained with chi-square (SPSS release-15). Final diagnosis was: 98 new lesions (N) (one to three), 28 multinodular HCC (Nmulti) and 14 loco-regional regrowth (LR); in 94 no more lesions were observed during follow-up; conventional US obtained: 58 N (+18 multinodularN and 8 LR), 40 false negative (+10 Nmulti and 6 LR) (sens:59.2, spec:100%, Diagn Accur:73.6, PPV:100; NPV:70.1); spiral CT obtained: 84N (+26-multinodularN and 14-LR), 14 false-negative (+2-Nmulti), and one false-positive (sens:85.7, spec:97.9%, Diagn Accur:90.9, PPV:97.7; NPV:86.8); 3DNAV obtained: 92N (+28 multinodularN and 14LR), 6 false-negative, and two false-positives (sens:93.9, spec:97.9%, Diagn Accur:95.6, PPV:97.9; NPV:93.9). 3-DNav CEUS is significantly better than US and almost similar to spiral CT for detection of new HCC. This technique, in particular, showed the presence of lesions even in the cases not detected with spiral CT.

No MeSH data available.


Related in: MedlinePlus