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Comparison of Locoregional Recurrence with Mastectomy vs. Breast Conserving Surgery in Pregnancy Associated Breast Cancer (PABC).

Beriwal S, Rungruang B, Soran A, Thull D, Kelley JL, Bhargava R, Lin CJ, Sukumvanich P - Cancers (Basel) (2009)

Bottom Line: The groups were comparable except for lower mean age in group 2 and more patients with stage III disease and higher number of nodes positive in the group 1.Five-year actuarial LRR, distant metastases free survival and overall survival in group 1 vs. 2 were 10% vs. 37%, 73% vs. 81% and 57% vs. 59% respectively.The patients with PABC treated with breast conserving therapy, despite having lower stage disease, have a higher risk of local regional recurrence in comparison with those treated with mastectomy.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiation Oncology, Magee-Womens Hospital of UPMC, 300 Halket Street, Pittsburgh, PA 15213, USA. beriwals@upmc.edu.

ABSTRACT
We have compared outcomes, including the locoregional recurrence, between mastectomy and breast conserving therapy in PABC. Patients were divided into those who were treated with mastectomies (group 1) and those with breast conserving surgery (group 2). The groups were comparable except for lower mean age in group 2 and more patients with stage III disease and higher number of nodes positive in the group 1. Five-year actuarial LRR, distant metastases free survival and overall survival in group 1 vs. 2 were 10% vs. 37%, 73% vs. 81% and 57% vs. 59% respectively. The patients with PABC treated with breast conserving therapy, despite having lower stage disease, have a higher risk of local regional recurrence in comparison with those treated with mastectomy.

No MeSH data available.


Related in: MedlinePlus

K-M Curve Showing Loco-regional Recurrence Free Survival.
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cancers-01-00012-f001: K-M Curve Showing Loco-regional Recurrence Free Survival.

Mentions: All patients in the BCT group and 14 patients in the mastectomy group had adjuvant radiation therapy. The median time interval between surgery or last dose of adjuvant chemotherapy and adjuvant radiation therapy was four weeks (3–10 weeks). At mean follow up of 55 months (2–194 months), nine patients in BCT group and four patients in mastectomy group had local recurrence with five actuarial recurrence rate of 37% and 10% respectively (Figure 1; p = 0.04). Sites of recurrence for the BCT group included ipsilateral breast (seven patients) and axilla (two patients). Sites of recurrence for the mastectomy group include chest wall in four patients. On univariate analysis, the only factor significant for LRR was type of surgery with BCT having a higher recurrence rate than mastectomy. When excluding from analysis the two patients with nodal recurrence in the BCT group, the difference between the two groups was not statistically significant. On multivariate analysis including stage, nodal status, grade, age, LVSI, and type of surgery, no variable was associated with increased risk of recurrence.


Comparison of Locoregional Recurrence with Mastectomy vs. Breast Conserving Surgery in Pregnancy Associated Breast Cancer (PABC).

Beriwal S, Rungruang B, Soran A, Thull D, Kelley JL, Bhargava R, Lin CJ, Sukumvanich P - Cancers (Basel) (2009)

K-M Curve Showing Loco-regional Recurrence Free Survival.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3757348&req=5

cancers-01-00012-f001: K-M Curve Showing Loco-regional Recurrence Free Survival.
Mentions: All patients in the BCT group and 14 patients in the mastectomy group had adjuvant radiation therapy. The median time interval between surgery or last dose of adjuvant chemotherapy and adjuvant radiation therapy was four weeks (3–10 weeks). At mean follow up of 55 months (2–194 months), nine patients in BCT group and four patients in mastectomy group had local recurrence with five actuarial recurrence rate of 37% and 10% respectively (Figure 1; p = 0.04). Sites of recurrence for the BCT group included ipsilateral breast (seven patients) and axilla (two patients). Sites of recurrence for the mastectomy group include chest wall in four patients. On univariate analysis, the only factor significant for LRR was type of surgery with BCT having a higher recurrence rate than mastectomy. When excluding from analysis the two patients with nodal recurrence in the BCT group, the difference between the two groups was not statistically significant. On multivariate analysis including stage, nodal status, grade, age, LVSI, and type of surgery, no variable was associated with increased risk of recurrence.

Bottom Line: The groups were comparable except for lower mean age in group 2 and more patients with stage III disease and higher number of nodes positive in the group 1.Five-year actuarial LRR, distant metastases free survival and overall survival in group 1 vs. 2 were 10% vs. 37%, 73% vs. 81% and 57% vs. 59% respectively.The patients with PABC treated with breast conserving therapy, despite having lower stage disease, have a higher risk of local regional recurrence in comparison with those treated with mastectomy.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiation Oncology, Magee-Womens Hospital of UPMC, 300 Halket Street, Pittsburgh, PA 15213, USA. beriwals@upmc.edu.

ABSTRACT
We have compared outcomes, including the locoregional recurrence, between mastectomy and breast conserving therapy in PABC. Patients were divided into those who were treated with mastectomies (group 1) and those with breast conserving surgery (group 2). The groups were comparable except for lower mean age in group 2 and more patients with stage III disease and higher number of nodes positive in the group 1. Five-year actuarial LRR, distant metastases free survival and overall survival in group 1 vs. 2 were 10% vs. 37%, 73% vs. 81% and 57% vs. 59% respectively. The patients with PABC treated with breast conserving therapy, despite having lower stage disease, have a higher risk of local regional recurrence in comparison with those treated with mastectomy.

No MeSH data available.


Related in: MedlinePlus