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Dissociation between memory retention across a delay and pattern separation following medial prefrontal cortex lesions in the touchscreen TUNL task.

McAllister KA, Saksida LM, Bussey TJ - Neurobiol Learn Mem (2013)

Bottom Line: The neural structures that support the retention of memories over time has been a subject of intense research in cognitive neuroscience.It remains unclear, however, to what extent these two processes can be neurally dissociated.When compared with previously published results, these data show that whereas the prefrontal cortex and hippocampus likely interact in the service of working memory across a delay, only the hippocampus and not the medial prefrontal cortex is essential for pattern separation.

View Article: PubMed Central - PubMed

Affiliation: University of Cambridge Department of Psychology, Downing Street, Cambridge, CB2 3EB, UK. kalmcallister@gmail.com

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mPFC lesions in the present study. Damage common to all subjects is shown in black. The maximum extent of any damage is shown by the black line. Coronal sections are taken at 3.72 mm, 2.76 mm, and 1.08 mm anterior to bregma. Images adapted from Paxinos and Watson (2007).
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f0010: mPFC lesions in the present study. Damage common to all subjects is shown in black. The maximum extent of any damage is shown by the black line. Coronal sections are taken at 3.72 mm, 2.76 mm, and 1.08 mm anterior to bregma. Images adapted from Paxinos and Watson (2007).


Dissociation between memory retention across a delay and pattern separation following medial prefrontal cortex lesions in the touchscreen TUNL task.

McAllister KA, Saksida LM, Bussey TJ - Neurobiol Learn Mem (2013)

mPFC lesions in the present study. Damage common to all subjects is shown in black. The maximum extent of any damage is shown by the black line. Coronal sections are taken at 3.72 mm, 2.76 mm, and 1.08 mm anterior to bregma. Images adapted from Paxinos and Watson (2007).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3757163&req=5

f0010: mPFC lesions in the present study. Damage common to all subjects is shown in black. The maximum extent of any damage is shown by the black line. Coronal sections are taken at 3.72 mm, 2.76 mm, and 1.08 mm anterior to bregma. Images adapted from Paxinos and Watson (2007).
Bottom Line: The neural structures that support the retention of memories over time has been a subject of intense research in cognitive neuroscience.It remains unclear, however, to what extent these two processes can be neurally dissociated.When compared with previously published results, these data show that whereas the prefrontal cortex and hippocampus likely interact in the service of working memory across a delay, only the hippocampus and not the medial prefrontal cortex is essential for pattern separation.

View Article: PubMed Central - PubMed

Affiliation: University of Cambridge Department of Psychology, Downing Street, Cambridge, CB2 3EB, UK. kalmcallister@gmail.com

Show MeSH
Related in: MedlinePlus