Dissociation between memory retention across a delay and pattern separation following medial prefrontal cortex lesions in the touchscreen TUNL task.
Bottom Line: The neural structures that support the retention of memories over time has been a subject of intense research in cognitive neuroscience.It remains unclear, however, to what extent these two processes can be neurally dissociated.When compared with previously published results, these data show that whereas the prefrontal cortex and hippocampus likely interact in the service of working memory across a delay, only the hippocampus and not the medial prefrontal cortex is essential for pattern separation.
Affiliation: University of Cambridge Department of Psychology, Downing Street, Cambridge, CB2 3EB, UK. email@example.comShow MeSH
Related in: MedlinePlus
Mentions: The TUNL task consists of two phases: sample and choice. At the sample phase one location within a grid of fourteen squares is illuminated. The rat must respond to the illuminated sample location, then return to the rear food magazine (sample is rewarded in 33% of trials) to initiate the choice phase. During the choice phase the sample square and a novel square are illuminated, and the rat must correctly non-match by selecting the novel square (Fig. 1). A delay can be placed between the sample and choice phases to tax working memory.
Affiliation: University of Cambridge Department of Psychology, Downing Street, Cambridge, CB2 3EB, UK. firstname.lastname@example.org