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Ethnic differences in neonatal body composition in a multi-ethnic population and the impact of parental factors: a population-based cohort study.

Sletner L, Nakstad B, Yajnik CS, Mørkrid K, Vangen S, Vårdal MH, Holme IM, Birkeland KI, Jenum AK - PLoS ONE (2013)

Bottom Line: Neonates from low and middle income countries (LAMIC) tend to have lower birth weight compared with Western European (WE) neonates.Parental height, BMI and maternal parity, age and educational level often differ according to ethnic background, and are associated with offspring birth weight.LAMIC origin neonates were relatively "thin-fat", as indicated by reduced AC and ponderal index and relatively preserved length and skin folds, compared with neonates with WE origin.

View Article: PubMed Central - PubMed

Affiliation: Institute of Clinical Medicine, University of Oslo, Oslo, Norway. line.sletner@medisin.uio.no

ABSTRACT

Background: Neonates from low and middle income countries (LAMIC) tend to have lower birth weight compared with Western European (WE) neonates. Parental height, BMI and maternal parity, age and educational level often differ according to ethnic background, and are associated with offspring birth weight. Less is known about how these factors affect ethnic differences in neonatal body composition.

Objectives: To explore differences in neonatal body composition in a multi-ethnic population, and the impact of key parental factors on these differences.

Methods: A population-based cohort study of pregnant mothers, fathers and their offspring, living in Oslo, Norway. Gender- and gestational-specific z-scores were calculated for several anthropometric measurements, with the neonates of WE ethnic origin as reference. Mean z-scores for neonates with LAMIC origin, and their parents, are presented as outcome variables.

Results: 537 singleton, term neonates and their parents were included. All anthropometric measurements were smaller in neonates with LAMIC origin. Abdominal circumference and ponderal index differed the most from WE (mean z-score: -0.57 (95% CI:-0.69 to -0.44) and -0.54 (-0.66 to -0.44), and remained so after adjusting for parental size. Head circumference and skin folds differed less, and length the least (-0.21 (-0.35 to -0.07)). These measures became comparable to WEs when adjusted for parental factors.

Conclusions: LAMIC origin neonates were relatively "thin-fat", as indicated by reduced AC and ponderal index and relatively preserved length and skin folds, compared with neonates with WE origin. This phenotype may predispose to type 2 diabetes.

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Mean z-scores (95% CI) for selected anthropometric measurements for neonates with ethnic origin from LAMIC with ethnic Western Europeans as reference.Model 1: unadjusted estimates. Model 2: estimates adjusted for maternal parity, height and BMI. Model 3: estimates adjusted for maternal factors as in model 2 and maternal age and education. Model 4: estimates adjusted for all factors as in model 3 and paternal height and BMI.
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pone-0073058-g003: Mean z-scores (95% CI) for selected anthropometric measurements for neonates with ethnic origin from LAMIC with ethnic Western Europeans as reference.Model 1: unadjusted estimates. Model 2: estimates adjusted for maternal parity, height and BMI. Model 3: estimates adjusted for maternal factors as in model 2 and maternal age and education. Model 4: estimates adjusted for all factors as in model 3 and paternal height and BMI.

Mentions: Figure 3 presents the mean z-scores for selected measurements for LAMIC neonates. In the unadjusted model (Model 1) BW, ponderal index and AC were most reduced in LAMIC neonates with a mean neonatal z-score of −0.50 (−0.63, −0.37), −0.54 (−0.66, −0.41) and −0.57 (−0.69, −0.44), respectively, compared with WE. Sum of skin folds and HC were less and CH-length least affected (−0.21 (−0.35, −0.07), p = 0.03).


Ethnic differences in neonatal body composition in a multi-ethnic population and the impact of parental factors: a population-based cohort study.

Sletner L, Nakstad B, Yajnik CS, Mørkrid K, Vangen S, Vårdal MH, Holme IM, Birkeland KI, Jenum AK - PLoS ONE (2013)

Mean z-scores (95% CI) for selected anthropometric measurements for neonates with ethnic origin from LAMIC with ethnic Western Europeans as reference.Model 1: unadjusted estimates. Model 2: estimates adjusted for maternal parity, height and BMI. Model 3: estimates adjusted for maternal factors as in model 2 and maternal age and education. Model 4: estimates adjusted for all factors as in model 3 and paternal height and BMI.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3756946&req=5

pone-0073058-g003: Mean z-scores (95% CI) for selected anthropometric measurements for neonates with ethnic origin from LAMIC with ethnic Western Europeans as reference.Model 1: unadjusted estimates. Model 2: estimates adjusted for maternal parity, height and BMI. Model 3: estimates adjusted for maternal factors as in model 2 and maternal age and education. Model 4: estimates adjusted for all factors as in model 3 and paternal height and BMI.
Mentions: Figure 3 presents the mean z-scores for selected measurements for LAMIC neonates. In the unadjusted model (Model 1) BW, ponderal index and AC were most reduced in LAMIC neonates with a mean neonatal z-score of −0.50 (−0.63, −0.37), −0.54 (−0.66, −0.41) and −0.57 (−0.69, −0.44), respectively, compared with WE. Sum of skin folds and HC were less and CH-length least affected (−0.21 (−0.35, −0.07), p = 0.03).

Bottom Line: Neonates from low and middle income countries (LAMIC) tend to have lower birth weight compared with Western European (WE) neonates.Parental height, BMI and maternal parity, age and educational level often differ according to ethnic background, and are associated with offspring birth weight.LAMIC origin neonates were relatively "thin-fat", as indicated by reduced AC and ponderal index and relatively preserved length and skin folds, compared with neonates with WE origin.

View Article: PubMed Central - PubMed

Affiliation: Institute of Clinical Medicine, University of Oslo, Oslo, Norway. line.sletner@medisin.uio.no

ABSTRACT

Background: Neonates from low and middle income countries (LAMIC) tend to have lower birth weight compared with Western European (WE) neonates. Parental height, BMI and maternal parity, age and educational level often differ according to ethnic background, and are associated with offspring birth weight. Less is known about how these factors affect ethnic differences in neonatal body composition.

Objectives: To explore differences in neonatal body composition in a multi-ethnic population, and the impact of key parental factors on these differences.

Methods: A population-based cohort study of pregnant mothers, fathers and their offspring, living in Oslo, Norway. Gender- and gestational-specific z-scores were calculated for several anthropometric measurements, with the neonates of WE ethnic origin as reference. Mean z-scores for neonates with LAMIC origin, and their parents, are presented as outcome variables.

Results: 537 singleton, term neonates and their parents were included. All anthropometric measurements were smaller in neonates with LAMIC origin. Abdominal circumference and ponderal index differed the most from WE (mean z-score: -0.57 (95% CI:-0.69 to -0.44) and -0.54 (-0.66 to -0.44), and remained so after adjusting for parental size. Head circumference and skin folds differed less, and length the least (-0.21 (-0.35 to -0.07)). These measures became comparable to WEs when adjusted for parental factors.

Conclusions: LAMIC origin neonates were relatively "thin-fat", as indicated by reduced AC and ponderal index and relatively preserved length and skin folds, compared with neonates with WE origin. This phenotype may predispose to type 2 diabetes.

Show MeSH
Related in: MedlinePlus