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Proton magnetic resonance spectroscopy ((1)H-MRS) reveals geniculocalcarine and striate area degeneration in primary glaucoma.

Zhang Y, Chen X, Wen G, Wu G, Zhang X - PLoS ONE (2013)

Bottom Line: The ratio of N-acetylaspartate (NAA)/Creatine (Cr), Choline (Cho)/Cr, glutamine and glutamate (Glx)/Cr were derived by multi-voxels (1)H-MRS in the GCT and the striate area of each brain hemisphere.The T1 intensity and T2 intensity had no difference between the groups.Significant decreases in NAA/Cr and Cho/Cr but no difference in Glx/Cr was found between the groups in both the GCT and the striate area.

View Article: PubMed Central - PubMed

Affiliation: Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen University, Guangzhou, GuangDong, China.

ABSTRACT

Background: Glaucoma is a collection of neurodegenerative diseases that affect both the retina and the central visual pathway. We investigated whether metabolites' concentrations changed in the geniculocalcarine (GCT) and the striate area of occipital lobe by proton magnetic resonance spectroscopy ((1)H-MRS), suggesting neurodegeneration of the central visual pathway in primary glaucoma.

Methodology/principal findings: 20 patients with glaucoma in both eyes were paired with 20 healthy volunteers in same gender and an age difference less than 3 years. All the participants were examined by MR imaging including T1 Flair, T2 FSE and (1)H-MRS. The T1 intensity and T2 intensity of their GCTs and striate areas were measured. The ratio of N-acetylaspartate (NAA)/Creatine (Cr), Choline (Cho)/Cr, glutamine and glutamate (Glx)/Cr were derived by multi-voxels (1)H-MRS in the GCT and the striate area of each brain hemisphere. The T1 intensity and T2 intensity had no difference between the groups. Significant decreases in NAA/Cr and Cho/Cr but no difference in Glx/Cr was found between the groups in both the GCT and the striate area.

Conclusions/significance: Primary glaucoma affects metabolites' concentrations in the GCT and the striate area suggesting there is ongoing neurodegenerative process.

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Related in: MedlinePlus

Regions of interest in the measurement of T2 intensity.Figure 2A displayed the ROIs of the GCTs, while Figure 2B displayed the ROIs of the striate area.
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pone-0073197-g002: Regions of interest in the measurement of T2 intensity.Figure 2A displayed the ROIs of the GCTs, while Figure 2B displayed the ROIs of the striate area.

Mentions: Measure the T1 intensity and T2 intensity of the GCTs regions of interest (ROIs) and the striate area ROIs in T1 Flair and T2WI FSE images. Each location was measured for three times to get the mean value. (Figure 2).


Proton magnetic resonance spectroscopy ((1)H-MRS) reveals geniculocalcarine and striate area degeneration in primary glaucoma.

Zhang Y, Chen X, Wen G, Wu G, Zhang X - PLoS ONE (2013)

Regions of interest in the measurement of T2 intensity.Figure 2A displayed the ROIs of the GCTs, while Figure 2B displayed the ROIs of the striate area.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3756940&req=5

pone-0073197-g002: Regions of interest in the measurement of T2 intensity.Figure 2A displayed the ROIs of the GCTs, while Figure 2B displayed the ROIs of the striate area.
Mentions: Measure the T1 intensity and T2 intensity of the GCTs regions of interest (ROIs) and the striate area ROIs in T1 Flair and T2WI FSE images. Each location was measured for three times to get the mean value. (Figure 2).

Bottom Line: The ratio of N-acetylaspartate (NAA)/Creatine (Cr), Choline (Cho)/Cr, glutamine and glutamate (Glx)/Cr were derived by multi-voxels (1)H-MRS in the GCT and the striate area of each brain hemisphere.The T1 intensity and T2 intensity had no difference between the groups.Significant decreases in NAA/Cr and Cho/Cr but no difference in Glx/Cr was found between the groups in both the GCT and the striate area.

View Article: PubMed Central - PubMed

Affiliation: Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen University, Guangzhou, GuangDong, China.

ABSTRACT

Background: Glaucoma is a collection of neurodegenerative diseases that affect both the retina and the central visual pathway. We investigated whether metabolites' concentrations changed in the geniculocalcarine (GCT) and the striate area of occipital lobe by proton magnetic resonance spectroscopy ((1)H-MRS), suggesting neurodegeneration of the central visual pathway in primary glaucoma.

Methodology/principal findings: 20 patients with glaucoma in both eyes were paired with 20 healthy volunteers in same gender and an age difference less than 3 years. All the participants were examined by MR imaging including T1 Flair, T2 FSE and (1)H-MRS. The T1 intensity and T2 intensity of their GCTs and striate areas were measured. The ratio of N-acetylaspartate (NAA)/Creatine (Cr), Choline (Cho)/Cr, glutamine and glutamate (Glx)/Cr were derived by multi-voxels (1)H-MRS in the GCT and the striate area of each brain hemisphere. The T1 intensity and T2 intensity had no difference between the groups. Significant decreases in NAA/Cr and Cho/Cr but no difference in Glx/Cr was found between the groups in both the GCT and the striate area.

Conclusions/significance: Primary glaucoma affects metabolites' concentrations in the GCT and the striate area suggesting there is ongoing neurodegenerative process.

Show MeSH
Related in: MedlinePlus