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Hemoglobin magnetism in aqueous solution probed by muon spin relaxation and future applications to brain research.

Nagamine K, Shimomura K, Miyadera H, Kim YJ, Scheicher RH, Das TP, Schultz JS - Proc. Jpn. Acad., Ser. B, Phys. Biol. Sci. (2007)

Bottom Line: A marked difference in spin relaxation behavior due to hemoglobin magnetism was found for positive muons (μ(+)) in deoxyhemoglobin in comparison with that observed in oxyhemoglobin in aqueous solution at room temperature under zero and external longitudinal magnetic fields upto 0.4 Tesla.At the same time, small but significant unique relaxation pattern was observed in nonmagnetic oxyhemoglobin.Combined with our previous measurements on hemoglobin in human blood, application of this type of measurement to the studies of the level of oxygenation in various regions of the human brain is suggested.

View Article: PubMed Central - PubMed

Affiliation: Atomic Physics Laboratory, RIKEN, Saitama, Japan . ; Muon Science Laboratory, Institute of Materials Structure Science, KEK, Ibaraki, Japan . ; Physics Department, University of California, Riverside, Riverside, U.S.A .

ABSTRACT
A marked difference in spin relaxation behavior due to hemoglobin magnetism was found for positive muons (μ(+)) in deoxyhemoglobin in comparison with that observed in oxyhemoglobin in aqueous solution at room temperature under zero and external longitudinal magnetic fields upto 0.4 Tesla. At the same time, small but significant unique relaxation pattern was observed in nonmagnetic oxyhemoglobin. Combined with our previous measurements on hemoglobin in human blood, application of this type of measurement to the studies of the level of oxygenation in various regions of the human brain is suggested.

No MeSH data available.


Longitudinal decoupling pattern representing asymmetry at around 1 μs versus applied longitudinal magnetic field for positive muon in oxyhemoglobin containing human blood and deoxyhemoglobin containing human blood at room temperature taken from our previous work.5)
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f3-83_120: Longitudinal decoupling pattern representing asymmetry at around 1 μs versus applied longitudinal magnetic field for positive muon in oxyhemoglobin containing human blood and deoxyhemoglobin containing human blood at room temperature taken from our previous work.5)

Mentions: Almost similar results of muon spin relaxation were obtained; characteristic features of the zero-field relaxation and longitudinal-field decoupling (Fig. 3) are essentially the same as those for the hemoglobin in aqueous solution (Fig. 2b). It should be noted that the local concentration increase of Hb inside each blood cell does not affect the overall feature of the decoupling pattern. Thus, these results are consistent with the picture that the major part of muon spin relaxation in deoxy-Hb is explained by the fluctuating paramagnetic Fe spin, while that in oxy-Hb is explained by the mostly non-magnetic Fe spin.


Hemoglobin magnetism in aqueous solution probed by muon spin relaxation and future applications to brain research.

Nagamine K, Shimomura K, Miyadera H, Kim YJ, Scheicher RH, Das TP, Schultz JS - Proc. Jpn. Acad., Ser. B, Phys. Biol. Sci. (2007)

Longitudinal decoupling pattern representing asymmetry at around 1 μs versus applied longitudinal magnetic field for positive muon in oxyhemoglobin containing human blood and deoxyhemoglobin containing human blood at room temperature taken from our previous work.5)
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3756736&req=5

f3-83_120: Longitudinal decoupling pattern representing asymmetry at around 1 μs versus applied longitudinal magnetic field for positive muon in oxyhemoglobin containing human blood and deoxyhemoglobin containing human blood at room temperature taken from our previous work.5)
Mentions: Almost similar results of muon spin relaxation were obtained; characteristic features of the zero-field relaxation and longitudinal-field decoupling (Fig. 3) are essentially the same as those for the hemoglobin in aqueous solution (Fig. 2b). It should be noted that the local concentration increase of Hb inside each blood cell does not affect the overall feature of the decoupling pattern. Thus, these results are consistent with the picture that the major part of muon spin relaxation in deoxy-Hb is explained by the fluctuating paramagnetic Fe spin, while that in oxy-Hb is explained by the mostly non-magnetic Fe spin.

Bottom Line: A marked difference in spin relaxation behavior due to hemoglobin magnetism was found for positive muons (μ(+)) in deoxyhemoglobin in comparison with that observed in oxyhemoglobin in aqueous solution at room temperature under zero and external longitudinal magnetic fields upto 0.4 Tesla.At the same time, small but significant unique relaxation pattern was observed in nonmagnetic oxyhemoglobin.Combined with our previous measurements on hemoglobin in human blood, application of this type of measurement to the studies of the level of oxygenation in various regions of the human brain is suggested.

View Article: PubMed Central - PubMed

Affiliation: Atomic Physics Laboratory, RIKEN, Saitama, Japan . ; Muon Science Laboratory, Institute of Materials Structure Science, KEK, Ibaraki, Japan . ; Physics Department, University of California, Riverside, Riverside, U.S.A .

ABSTRACT
A marked difference in spin relaxation behavior due to hemoglobin magnetism was found for positive muons (μ(+)) in deoxyhemoglobin in comparison with that observed in oxyhemoglobin in aqueous solution at room temperature under zero and external longitudinal magnetic fields upto 0.4 Tesla. At the same time, small but significant unique relaxation pattern was observed in nonmagnetic oxyhemoglobin. Combined with our previous measurements on hemoglobin in human blood, application of this type of measurement to the studies of the level of oxygenation in various regions of the human brain is suggested.

No MeSH data available.