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Hemoglobin magnetism in aqueous solution probed by muon spin relaxation and future applications to brain research.

Nagamine K, Shimomura K, Miyadera H, Kim YJ, Scheicher RH, Das TP, Schultz JS - Proc. Jpn. Acad., Ser. B, Phys. Biol. Sci. (2007)

Bottom Line: A marked difference in spin relaxation behavior due to hemoglobin magnetism was found for positive muons (μ(+)) in deoxyhemoglobin in comparison with that observed in oxyhemoglobin in aqueous solution at room temperature under zero and external longitudinal magnetic fields upto 0.4 Tesla.At the same time, small but significant unique relaxation pattern was observed in nonmagnetic oxyhemoglobin.Combined with our previous measurements on hemoglobin in human blood, application of this type of measurement to the studies of the level of oxygenation in various regions of the human brain is suggested.

View Article: PubMed Central - PubMed

Affiliation: Atomic Physics Laboratory, RIKEN, Saitama, Japan . ; Muon Science Laboratory, Institute of Materials Structure Science, KEK, Ibaraki, Japan . ; Physics Department, University of California, Riverside, Riverside, U.S.A .

ABSTRACT
A marked difference in spin relaxation behavior due to hemoglobin magnetism was found for positive muons (μ(+)) in deoxyhemoglobin in comparison with that observed in oxyhemoglobin in aqueous solution at room temperature under zero and external longitudinal magnetic fields upto 0.4 Tesla. At the same time, small but significant unique relaxation pattern was observed in nonmagnetic oxyhemoglobin. Combined with our previous measurements on hemoglobin in human blood, application of this type of measurement to the studies of the level of oxygenation in various regions of the human brain is suggested.

No MeSH data available.


Muon spin relaxation time spectrum in hemoglobin aqueous solution at room temperature in a long time range observed with pulsed muon beam at KEK. The data is presented in terms of muon polarization as shown in the text.
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f1a-83_120: Muon spin relaxation time spectrum in hemoglobin aqueous solution at room temperature in a long time range observed with pulsed muon beam at KEK. The data is presented in terms of muon polarization as shown in the text.

Mentions: Among the obtained sets of data, typical time-spectrum data at zero-field and at room temperature are shown in Fig. 1a and 1b. There, the average polarization of the muon stopping in the whole sample is presented as a function of time after muon-stopping. The absolute value of polarization was obtained by the saturated value of the positron asymmetry in the decoupling measurement (the polarization recovery measurement under the magnetic field applied along the initial muon polarization direction) shown later for the 100% value and the amplitude of the muon spin rotation in Al for the baseline (0% asymmetry) determination. A clear difference between μ+ in deoxy-Hb versus μ+ in oxy-Hb in aqueous solution was seen in earlier time range at 100 ns; the asymmetry at 100 ns being 82% versus 68% (Fig. 1a) and a weak but significant difference in spin relaxation rate in the time region from 1 to 10 μs (Fig. 1a). The enhanced reduction of the muon polarization in the earlier time-range in the deoxy-Hb sample should be related to a muon spin depolarization by a fluctuating local magnetic field from paramagnetic heme-Fe magnetic moment.


Hemoglobin magnetism in aqueous solution probed by muon spin relaxation and future applications to brain research.

Nagamine K, Shimomura K, Miyadera H, Kim YJ, Scheicher RH, Das TP, Schultz JS - Proc. Jpn. Acad., Ser. B, Phys. Biol. Sci. (2007)

Muon spin relaxation time spectrum in hemoglobin aqueous solution at room temperature in a long time range observed with pulsed muon beam at KEK. The data is presented in terms of muon polarization as shown in the text.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3756736&req=5

f1a-83_120: Muon spin relaxation time spectrum in hemoglobin aqueous solution at room temperature in a long time range observed with pulsed muon beam at KEK. The data is presented in terms of muon polarization as shown in the text.
Mentions: Among the obtained sets of data, typical time-spectrum data at zero-field and at room temperature are shown in Fig. 1a and 1b. There, the average polarization of the muon stopping in the whole sample is presented as a function of time after muon-stopping. The absolute value of polarization was obtained by the saturated value of the positron asymmetry in the decoupling measurement (the polarization recovery measurement under the magnetic field applied along the initial muon polarization direction) shown later for the 100% value and the amplitude of the muon spin rotation in Al for the baseline (0% asymmetry) determination. A clear difference between μ+ in deoxy-Hb versus μ+ in oxy-Hb in aqueous solution was seen in earlier time range at 100 ns; the asymmetry at 100 ns being 82% versus 68% (Fig. 1a) and a weak but significant difference in spin relaxation rate in the time region from 1 to 10 μs (Fig. 1a). The enhanced reduction of the muon polarization in the earlier time-range in the deoxy-Hb sample should be related to a muon spin depolarization by a fluctuating local magnetic field from paramagnetic heme-Fe magnetic moment.

Bottom Line: A marked difference in spin relaxation behavior due to hemoglobin magnetism was found for positive muons (μ(+)) in deoxyhemoglobin in comparison with that observed in oxyhemoglobin in aqueous solution at room temperature under zero and external longitudinal magnetic fields upto 0.4 Tesla.At the same time, small but significant unique relaxation pattern was observed in nonmagnetic oxyhemoglobin.Combined with our previous measurements on hemoglobin in human blood, application of this type of measurement to the studies of the level of oxygenation in various regions of the human brain is suggested.

View Article: PubMed Central - PubMed

Affiliation: Atomic Physics Laboratory, RIKEN, Saitama, Japan . ; Muon Science Laboratory, Institute of Materials Structure Science, KEK, Ibaraki, Japan . ; Physics Department, University of California, Riverside, Riverside, U.S.A .

ABSTRACT
A marked difference in spin relaxation behavior due to hemoglobin magnetism was found for positive muons (μ(+)) in deoxyhemoglobin in comparison with that observed in oxyhemoglobin in aqueous solution at room temperature under zero and external longitudinal magnetic fields upto 0.4 Tesla. At the same time, small but significant unique relaxation pattern was observed in nonmagnetic oxyhemoglobin. Combined with our previous measurements on hemoglobin in human blood, application of this type of measurement to the studies of the level of oxygenation in various regions of the human brain is suggested.

No MeSH data available.