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A New Tiapride Selective Electrode and Its Clinical Application

View Article: PubMed Central

ABSTRACT

The construction and electrochemical response characteristics of a poly(vinyl chloride) (PVC) membrane selective electrode for the determination of tiapride (TPD) are described. The sensing membrane comprised an ion-pair formed between the protonated drug and tetraphenylborate (TPB-) in a plasticized PVC matrix. The influence of membrane composition on the electrode response was studied. The electrode showed a fast, stable and Nernstian response over a wide tiapride concentration range (1x10-5-1x10-2 M) with a slope of 57.5±0.2 mV dec-1 of concentration, a detection limit of 4.3x10-6±2.5x10-7 M, a wide working pH range (2-8) and a fast response time (< 5 s). The electrode showed good selectivity towards tiapride with respect to some inorganic and organic compounds. The electrode has been applied to the determination of tiapride in human urine and iontophoresis solution.

No MeSH data available.


Calibration graphs for membranes A, B and C.
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f1-sensors-07-00400: Calibration graphs for membranes A, B and C.

Mentions: Several membranes of the different compositions (Table 1) prepared as described in the Experimental were tested. Two plasticizers, NPOE and DOS, with very different dielectric constants were tested as membrane solvent. The calibration graphs obtained for the corresponding membranes, A and B respectively, are shown in Fig. 1.


A New Tiapride Selective Electrode and Its Clinical Application
Calibration graphs for membranes A, B and C.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3756728&req=5

f1-sensors-07-00400: Calibration graphs for membranes A, B and C.
Mentions: Several membranes of the different compositions (Table 1) prepared as described in the Experimental were tested. Two plasticizers, NPOE and DOS, with very different dielectric constants were tested as membrane solvent. The calibration graphs obtained for the corresponding membranes, A and B respectively, are shown in Fig. 1.

View Article: PubMed Central

ABSTRACT

The construction and electrochemical response characteristics of a poly(vinyl chloride) (PVC) membrane selective electrode for the determination of tiapride (TPD) are described. The sensing membrane comprised an ion-pair formed between the protonated drug and tetraphenylborate (TPB-) in a plasticized PVC matrix. The influence of membrane composition on the electrode response was studied. The electrode showed a fast, stable and Nernstian response over a wide tiapride concentration range (1x10-5-1x10-2 M) with a slope of 57.5±0.2 mV dec-1 of concentration, a detection limit of 4.3x10-6±2.5x10-7 M, a wide working pH range (2-8) and a fast response time (< 5 s). The electrode showed good selectivity towards tiapride with respect to some inorganic and organic compounds. The electrode has been applied to the determination of tiapride in human urine and iontophoresis solution.

No MeSH data available.