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Effects of walnuts on endothelial function in overweight adults with visceral obesity: a randomized, controlled, crossover trial.

Katz DL, Davidhi A, Ma Y, Kavak Y, Bifulco L, Njike VY - J Am Coll Nutr (2012)

Bottom Line: Walnut ingestion has been shown to reduce CVD risk indices in diabetes.Beneficial trends in systolic blood pressure reduction were seen, and maintenance of the baseline anthropometric values was also observed.Further study of the potential role of walnut intake in diabetes and CVD prevention is warranted.

View Article: PubMed Central - PubMed

Affiliation: Yale University, Griffin Prevention Research Center, 130 Division Street, Derby, CT 06418, USA. katzdl@pol.net

ABSTRACT

Objectives: Metabolic syndrome is a precursor of diabetes and cardiovascular disease (CVD). Walnut ingestion has been shown to reduce CVD risk indices in diabetes. This randomized controlled crossover trial was performed to investigate the effects of daily walnut consumption on endothelial function and other biomarkers of cardiac risk in a population of overweight individuals with visceral adiposity.

Methods: Forty-six overweight adults (average age, 57.4 years; 28 women, 18 men) with elevated waist circumference and 1 or more additional signs of metabolic syndrome were randomly assigned to two 8-week sequences of walnut-enriched ad libitum diet and ad libitum diet without walnuts, which were separated by a 4-week washout period. The primary outcome measure was the change in flow-mediated vasodilation (FMD) of the brachial artery. Secondary measures included serum lipid panel, fasting glucose and insulin, Homeostasis Model Assessment-Insulin Resistance values, blood pressure, and anthropometric measures.

Results: FMD improved significantly from baseline when subjects consumed a walnut-enriched diet as compared with the control diet (1.4% ± 2.4% versus 0.3% ± 1.5%; p = 0.019). Beneficial trends in systolic blood pressure reduction were seen, and maintenance of the baseline anthropometric values was also observed. Other measures were unaltered.

Conclusion: Daily ingestion of 56 g of walnuts improves endothelial function in overweight adults with visceral adiposity. The addition of walnuts to the diet does not lead to weight gain. Further study of the potential role of walnut intake in diabetes and CVD prevention is warranted.

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Related in: MedlinePlus

Subject participation and study progression.
© Copyright Policy - open-access
Related In: Results  -  Collection

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Figure 1: Subject participation and study progression.

Mentions: Those passing the telephone screening (n = 92) underwent a clinical screening examination consisting of height, weight, BMI, blood pressure measurements, and laboratory testing including fasting serum lipids and FPG. Subject participation and study progression are shown in Fig. 1.


Effects of walnuts on endothelial function in overweight adults with visceral obesity: a randomized, controlled, crossover trial.

Katz DL, Davidhi A, Ma Y, Kavak Y, Bifulco L, Njike VY - J Am Coll Nutr (2012)

Subject participation and study progression.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3756625&req=5

Figure 1: Subject participation and study progression.
Mentions: Those passing the telephone screening (n = 92) underwent a clinical screening examination consisting of height, weight, BMI, blood pressure measurements, and laboratory testing including fasting serum lipids and FPG. Subject participation and study progression are shown in Fig. 1.

Bottom Line: Walnut ingestion has been shown to reduce CVD risk indices in diabetes.Beneficial trends in systolic blood pressure reduction were seen, and maintenance of the baseline anthropometric values was also observed.Further study of the potential role of walnut intake in diabetes and CVD prevention is warranted.

View Article: PubMed Central - PubMed

Affiliation: Yale University, Griffin Prevention Research Center, 130 Division Street, Derby, CT 06418, USA. katzdl@pol.net

ABSTRACT

Objectives: Metabolic syndrome is a precursor of diabetes and cardiovascular disease (CVD). Walnut ingestion has been shown to reduce CVD risk indices in diabetes. This randomized controlled crossover trial was performed to investigate the effects of daily walnut consumption on endothelial function and other biomarkers of cardiac risk in a population of overweight individuals with visceral adiposity.

Methods: Forty-six overweight adults (average age, 57.4 years; 28 women, 18 men) with elevated waist circumference and 1 or more additional signs of metabolic syndrome were randomly assigned to two 8-week sequences of walnut-enriched ad libitum diet and ad libitum diet without walnuts, which were separated by a 4-week washout period. The primary outcome measure was the change in flow-mediated vasodilation (FMD) of the brachial artery. Secondary measures included serum lipid panel, fasting glucose and insulin, Homeostasis Model Assessment-Insulin Resistance values, blood pressure, and anthropometric measures.

Results: FMD improved significantly from baseline when subjects consumed a walnut-enriched diet as compared with the control diet (1.4% ± 2.4% versus 0.3% ± 1.5%; p = 0.019). Beneficial trends in systolic blood pressure reduction were seen, and maintenance of the baseline anthropometric values was also observed. Other measures were unaltered.

Conclusion: Daily ingestion of 56 g of walnuts improves endothelial function in overweight adults with visceral adiposity. The addition of walnuts to the diet does not lead to weight gain. Further study of the potential role of walnut intake in diabetes and CVD prevention is warranted.

Show MeSH
Related in: MedlinePlus