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Gold nanostructures as a platform for combinational therapy in future cancer therapeutics.

Jelveh S, Chithrani DB - Cancers (Basel) (2011)

Bottom Line: The field of nanotechnology is currently undergoing explosive development on many fronts.In addition, the heat generation capability of gold nanostructures upon exposure to UV or near infrared light is being used to damage tumor cells locally in photothermal therapy.In this review article, the recent progress in the development of gold-based NPs towards improved therapeutics will be discussed.

View Article: PubMed Central - PubMed

Affiliation: Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Toronto, ON, Canada. devika.chithrani@rmp.uhn.on.ca.

ABSTRACT
The field of nanotechnology is currently undergoing explosive development on many fronts. The technology is expected to generate innovations and play a critical role in cancer therapeutics. Among other nanoparticle (NP) systems, there has been tremendous progress made in the use of spherical gold NPs (GNPs), gold nanorods (GNRs), gold nanoshells (GNSs) and gold nanocages (GNCs) in cancer therapeutics. In treating cancer, radiation therapy and chemotherapy remain the most widely used treatment options and recent developments in cancer research show that the incorporation of gold nanostructures into these protocols has enhanced tumor cell killing. These nanostructures further provide strategies for better loading, targeting, and controlling the release of drugs to minimize the side effects of highly toxic anticancer drugs used in chemotherapy and photodynamic therapy. In addition, the heat generation capability of gold nanostructures upon exposure to UV or near infrared light is being used to damage tumor cells locally in photothermal therapy. Hence, gold nanostructures provide a versatile platform to integrate many therapeutic options leading to effective combinational therapy in the fight against cancer. In this review article, the recent progress in the development of gold-based NPs towards improved therapeutics will be discussed. A multifunctional platform based on gold nanostructures with targeting ligands, therapeutic molecules, and imaging contrast agents, holds an array of promising directions for cancer research.

No MeSH data available.


Related in: MedlinePlus

Future generation multifunctional NPs for improved therapeutics and imaging. Gold incorporated liposome or polymer NP, HGNS, and Polymer covered GNC as a new class of nanomaterials for improved therapeutics and imaging in cancer therapy.
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f12-cancers-03-01081: Future generation multifunctional NPs for improved therapeutics and imaging. Gold incorporated liposome or polymer NP, HGNS, and Polymer covered GNC as a new class of nanomaterials for improved therapeutics and imaging in cancer therapy.

Mentions: As illustrated in Figure 12A, GNPs can be incorporated into the surface of the polymer or liposome NPs while keeping imaging contrast agents and anticancer drugs encapsulated in the core for combining imaging, radiation therapy, and chemotherapy for improved outcome in future cancer care [159]. Although not used in clinics until now, the dual modality of cell killing, using photothermal ablation mediated and control release of anticancer drugs by HGNSs and GNCs upon NIR laser irradiation, will significantly increase the likelihood of cell killing and potentially overcome resistance to chemotherapeutic agents, making it another promising approach to future cancer therapy (see Figures 12B–12C) [15].


Gold nanostructures as a platform for combinational therapy in future cancer therapeutics.

Jelveh S, Chithrani DB - Cancers (Basel) (2011)

Future generation multifunctional NPs for improved therapeutics and imaging. Gold incorporated liposome or polymer NP, HGNS, and Polymer covered GNC as a new class of nanomaterials for improved therapeutics and imaging in cancer therapy.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3756404&req=5

f12-cancers-03-01081: Future generation multifunctional NPs for improved therapeutics and imaging. Gold incorporated liposome or polymer NP, HGNS, and Polymer covered GNC as a new class of nanomaterials for improved therapeutics and imaging in cancer therapy.
Mentions: As illustrated in Figure 12A, GNPs can be incorporated into the surface of the polymer or liposome NPs while keeping imaging contrast agents and anticancer drugs encapsulated in the core for combining imaging, radiation therapy, and chemotherapy for improved outcome in future cancer care [159]. Although not used in clinics until now, the dual modality of cell killing, using photothermal ablation mediated and control release of anticancer drugs by HGNSs and GNCs upon NIR laser irradiation, will significantly increase the likelihood of cell killing and potentially overcome resistance to chemotherapeutic agents, making it another promising approach to future cancer therapy (see Figures 12B–12C) [15].

Bottom Line: The field of nanotechnology is currently undergoing explosive development on many fronts.In addition, the heat generation capability of gold nanostructures upon exposure to UV or near infrared light is being used to damage tumor cells locally in photothermal therapy.In this review article, the recent progress in the development of gold-based NPs towards improved therapeutics will be discussed.

View Article: PubMed Central - PubMed

Affiliation: Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Toronto, ON, Canada. devika.chithrani@rmp.uhn.on.ca.

ABSTRACT
The field of nanotechnology is currently undergoing explosive development on many fronts. The technology is expected to generate innovations and play a critical role in cancer therapeutics. Among other nanoparticle (NP) systems, there has been tremendous progress made in the use of spherical gold NPs (GNPs), gold nanorods (GNRs), gold nanoshells (GNSs) and gold nanocages (GNCs) in cancer therapeutics. In treating cancer, radiation therapy and chemotherapy remain the most widely used treatment options and recent developments in cancer research show that the incorporation of gold nanostructures into these protocols has enhanced tumor cell killing. These nanostructures further provide strategies for better loading, targeting, and controlling the release of drugs to minimize the side effects of highly toxic anticancer drugs used in chemotherapy and photodynamic therapy. In addition, the heat generation capability of gold nanostructures upon exposure to UV or near infrared light is being used to damage tumor cells locally in photothermal therapy. Hence, gold nanostructures provide a versatile platform to integrate many therapeutic options leading to effective combinational therapy in the fight against cancer. In this review article, the recent progress in the development of gold-based NPs towards improved therapeutics will be discussed. A multifunctional platform based on gold nanostructures with targeting ligands, therapeutic molecules, and imaging contrast agents, holds an array of promising directions for cancer research.

No MeSH data available.


Related in: MedlinePlus