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Cell-centric view of apoptosis and apoptotic cell death-inducing antitumoral strategies.

Apraiz A, Boyano MD, Asumendi A - Cancers (Basel) (2011)

Bottom Line: In this context, an extensive description of pathway-connections is necessary in order to point out the main regulatory molecules as well as to select the most appropriate therapeutic targets.In fact, tumor cell plasticity represents a major challenge in chemotherapy and improvement on anticancer therapies seems to rely on appropriate drug combinations.An overview of the current status regarding apoptotic pathways as well as available chemotherapeutic compounds provides a new perspective of possible future anticancer strategies.

View Article: PubMed Central - PubMed

Affiliation: Department of Cell Biology and Histology, School of Medicine and Dentistry, University of the Basque Country, 48940, Leioa (Bizkaia), Spain. aintzane.asumendi@ehu.es.

ABSTRACT
Programmed cell death and especially apoptotic cell death, occurs under physiological conditions and is also desirable under pathological circumstances. However, the more we learn about cellular signaling cascades, the less plausible it becomes to find restricted and well-limited signaling pathways. In this context, an extensive description of pathway-connections is necessary in order to point out the main regulatory molecules as well as to select the most appropriate therapeutic targets. On the other hand, irregularities in programmed cell death pathways often lead to tumor development and cancer-related mortality is projected to continue increasing despite the effort to develop more active and selective antitumoral compounds. In fact, tumor cell plasticity represents a major challenge in chemotherapy and improvement on anticancer therapies seems to rely on appropriate drug combinations. An overview of the current status regarding apoptotic pathways as well as available chemotherapeutic compounds provides a new perspective of possible future anticancer strategies.

No MeSH data available.


Related in: MedlinePlus

Drugs targeting mitochondrion or lysosome. The figure represents an overview of compounds aimed to induce tumor cell death by interacting with specific molecules (as shown in the figure), by inducing oxidative damage or permeabilization of the lysosomal membrane.
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f6-cancers-03-01042: Drugs targeting mitochondrion or lysosome. The figure represents an overview of compounds aimed to induce tumor cell death by interacting with specific molecules (as shown in the figure), by inducing oxidative damage or permeabilization of the lysosomal membrane.

Mentions: Mitochondria are complex organelles with two main and unique characteristics: (1) the presence of its own genetic material (circular DNA) that encodes several, although not all, proteins of the mitochondrial respiratory chain and (2) a double membrane structure. The double membrane structure is essential for proton (H+) gradient formation, which ultimately drives energy generation (adenosine-triphosphate, ATP, molecules). The proton (H+) gradient, and thus Δψm, originates from the accumulation of H+ in the intermembrane space (IMS) via active pumping from the mitochondrial matrix (see Figure 6).


Cell-centric view of apoptosis and apoptotic cell death-inducing antitumoral strategies.

Apraiz A, Boyano MD, Asumendi A - Cancers (Basel) (2011)

Drugs targeting mitochondrion or lysosome. The figure represents an overview of compounds aimed to induce tumor cell death by interacting with specific molecules (as shown in the figure), by inducing oxidative damage or permeabilization of the lysosomal membrane.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3756403&req=5

f6-cancers-03-01042: Drugs targeting mitochondrion or lysosome. The figure represents an overview of compounds aimed to induce tumor cell death by interacting with specific molecules (as shown in the figure), by inducing oxidative damage or permeabilization of the lysosomal membrane.
Mentions: Mitochondria are complex organelles with two main and unique characteristics: (1) the presence of its own genetic material (circular DNA) that encodes several, although not all, proteins of the mitochondrial respiratory chain and (2) a double membrane structure. The double membrane structure is essential for proton (H+) gradient formation, which ultimately drives energy generation (adenosine-triphosphate, ATP, molecules). The proton (H+) gradient, and thus Δψm, originates from the accumulation of H+ in the intermembrane space (IMS) via active pumping from the mitochondrial matrix (see Figure 6).

Bottom Line: In this context, an extensive description of pathway-connections is necessary in order to point out the main regulatory molecules as well as to select the most appropriate therapeutic targets.In fact, tumor cell plasticity represents a major challenge in chemotherapy and improvement on anticancer therapies seems to rely on appropriate drug combinations.An overview of the current status regarding apoptotic pathways as well as available chemotherapeutic compounds provides a new perspective of possible future anticancer strategies.

View Article: PubMed Central - PubMed

Affiliation: Department of Cell Biology and Histology, School of Medicine and Dentistry, University of the Basque Country, 48940, Leioa (Bizkaia), Spain. aintzane.asumendi@ehu.es.

ABSTRACT
Programmed cell death and especially apoptotic cell death, occurs under physiological conditions and is also desirable under pathological circumstances. However, the more we learn about cellular signaling cascades, the less plausible it becomes to find restricted and well-limited signaling pathways. In this context, an extensive description of pathway-connections is necessary in order to point out the main regulatory molecules as well as to select the most appropriate therapeutic targets. On the other hand, irregularities in programmed cell death pathways often lead to tumor development and cancer-related mortality is projected to continue increasing despite the effort to develop more active and selective antitumoral compounds. In fact, tumor cell plasticity represents a major challenge in chemotherapy and improvement on anticancer therapies seems to rely on appropriate drug combinations. An overview of the current status regarding apoptotic pathways as well as available chemotherapeutic compounds provides a new perspective of possible future anticancer strategies.

No MeSH data available.


Related in: MedlinePlus